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Paul Joseph Dyson

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Publications associées (668)

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Direct Conversion of Mono- and Polysaccharides into 5-Hydroxymethylfurfural Using Ionic-Liquid Mixtures

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Ning Yan, Sviatlana Siankevich

Platform chemicals are usually derived from petrochemical feedstocks. A sustainable alternative commences with lignocellulosic biomass, a renewable feedstock, but one that is highly challenging to process. Ionic liquids (ILs) are able to solubilize biomass ...

Wiley-VCH Verlag Berlin2016

In Situ Formation of Frustrated Lewis Pairs in a Water-Tolerant Metal-Organic Framework for the Transformation of CO2

Paul Joseph Dyson, Kyriakos Stylianou, Ngoc Tú Nguyên, Fatmah Ebrahim, Serhii Shyshkanov

Frustrated Lewis pairs (FLPs) consist of sterically hindered Lewis acids and Lewis bases, which provide high catalytic activity towards non-metal-mediated activation of "inert" small molecules, including CO2 among others. One critical issue of homogeneous ...

Wiley-VCH Verlag GmbH2019

Selective Acceptorless Dehydrogenation of Primary Amines to Imines by Core-Shell Cobalt Nanoparticles

Paul Joseph Dyson, Zhaofu Fei, Xinjiang Cui

Core-shell nanocatalysts are attractive due to their versatility and stability. Here, we describe cobalt nanoparticles encapsulated within graphitic shells prepared via the pyrolysis of a cationic poly-ionic liquid (PIL) with a cobalt(II) chloride anion. T ...

Wiley-VCH Verlag GmbH2020

Use of a novel microbiome modulator improves anticancer immunity in a murine model of malignant pleural mesothelioma

Paul Joseph Dyson

Objective: Malignant pleural mesothelioma is a fatal disease and a clinical challenge, as few effective treatment modalities are available. Previous evidence links the gut microbiome to the host immunoreactivity to tumors. We thus evaluated the impact of a ...

2024

Halide exchange in the passivation of perovskite solar cells with functionalized ionic

Mohammad Khaja Nazeeruddin, Paul Joseph Dyson, Rosario Scopelliti, Andreas Züttel, Farzaneh Fadaei Tirani, Zhaofu Fei, Yi Zhang, Hiroyuki Kanda, Bin Ding, Wen Luo, Mo Li, Mousa Abdulla M E Abuhelaiqa

Applying additives to perovskite precursor solutions is an effective way to passivate perovskite films for the construction of perovskite solar cells (PSCs) with increased power-conversion efficiencies (PCEs) and enhanced stabilities. Ionic liquids (ILs) w ...

ELSEVIER2022

The Role of Organic Promoters in the Electroreduction of Carbon Dioxide

Paul Joseph Dyson, Dmitry Vasilyev

The electrochemical reduction of carbon dioxide (CO2RR) currently attracts considerable attention as a way to make fuels and value-added products from CO2 using renewable energy. Much effort has been devoted to developing efficient electrode materials for ...

AMER CHEMICAL SOC2021

The dilemma between acid and base catalysis in the synthesis of benzimidazole from o-phenylenediamine and carbon dioxide

Alexy Robert Bonnin, Paul Joseph Dyson, Simon Nussbaum, Martin Hulla

The tandem synthesis of benzimidazole and other azoles can be achived by the N-formylation of ortho-substituted anilines followed by a cyclization reaction. However, CO2-based N-formylations with hydrosilane reducing agents are base catalyzed whereas the c ...

Royal Society of Chemistry2019

Tuning the efficacy of ruthenium(II)-arene (RAPTA) antitumour compounds with fluorinated arene ligands

Paul Joseph Dyson, Rosario Scopelliti, Ursula Röthlisberger, Anna Katherine Renfrew, Andrew Douglas Phillips, Enrico Marko Tapavicza

A series of compounds of general formula [Ru(eta(6)-fluoroarene)(pta)Cl-2] (fluoroarene = C6H5F, C6H5CF3, and 1,4-C6H4CH3F; pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane) have been prepared and characterized spectroscopically. Additionally, X-ray dif ...

American Chemical Society2009

Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Novel Antitumor Compound, [Ru(eta(6)-p-phenylethacrynate)Cl-2(pta)]

Paul Joseph Dyson

The ruthenium-based complex [Ru(eta(6)-p-phenylethacrynate)Cl-2(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane), termed ethaRAPTA, is an interesting antitumor compound. The elucidation of the molecular mechanism of drug activity is central to ...

2012

α-Diimines as Versatile, Derivatizable Ligands in Ruthenium(II) p-Cymene Anticancer Complexes

Paul Joseph Dyson, Lucinda Kate Batchelor

α-Diimines are among the most robust and versatile ligands available in synthetic coordination chemistry, possessing finely tunable steric and electronic properties. A series of novel cationic ruthenium(II) p-cymene complexes bearing simple α-diimine ligan ...

2018

An Internal Fluorescent Probe Based on Anthracene to Evaluate Cation-Anion Interactions in Imidazolium Salts

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Christian Hartinger, Wee Han Ang, Xuemei Yang

A series of fluorescent imidazolium-based salts contg. the cation [AnCH2MeIm]+ (in which An=anthracene and Im=the imidazolium cation) with Cl-, BF4-, PF6-, SO3CF3-, [N(CN)2]-, [N(SO2CF3)2]-, or PhBF3- anions have been prepd. and characterized. X-ray diffra ...

2010

Drug Repurposing to Identify a Synergistic High-Order Drug Combination to Treat Sunitinib-Resistant Renal Cell Carcinoma

Paul Joseph Dyson

Simple Summary In this study, drug combination screening was used to design a multidrug combination consisting of repurposed drugs to treat sunitinib-resistant clear cell renal cell carcinoma. In the frame of this project, the multidrug combination has bee ...

MDPI2021

Classification of Metal-Based Drugs according to Their Mechanisms of Action

Paul Joseph Dyson

Metal-based drugs and imaging agents are extensively used in the clinic for the treatment and diagnosis of cancers and a wide range of other diseases. The current clinical arsenal of compounds operate via a limited number of mechanisms, whereas new putativ ...

CELL PRESS2020

A bifunctional organometallic ruthenium drug with multiple modes of inducing apoptosis

Paul Joseph Dyson, Ilaria Biondi

The organometallic glutathione S-transferase inhibitor ruthenium(II) (ethacrynic acid-η6-benzylamide)(1,3,5-triaza-7-phosphaadamantane) dichloride, termed ethaRAPTA, has been demonstrated to induce apoptosis in the cisplatin-resistant MCF-7 breast cancer c ...

Springer2011

Synthesis, Structure, and Anticancer Activity of Arene-Ruthenium(II) Complexes with Acylpyrazolones Bearing Aliphatic Groups in the Acyl Moiety

Paul Joseph Dyson, Rosario Scopelliti, Tina Riedel

A series of neutral ruthenium(II) arene complexes [(arene)Ru(Q(R))Cl] (arene = p-cymene (cym) or hexamethylbenzene (hmb)) containing 4-acyl-5-pyrazolonate Q(R) ligands with different electronic and steric substituents (R = 4-cyclohexyl, 4-stearoyl, or 4-ad ...

American Chemical Society2016

Highly Cytotoxic Copper(II) Complexes with Modified Paullone Ligands

Paul Joseph Dyson, Olivier Pierre Zava

The reaction of copper(II) chloride or copper(II) acetate with 6-N-(2-N',N'-dimethylaminoethylamino)-7,12-dihydroindolo-[3,2-d][1]benzazepine (HL1), 9-bromo-6-N-(2-N',N'-dimethylaminoethylamino)-7,12-dihydroindolo[3,2-d][1]benzazepine (HL2), N-9-bromo-7,12 ...

2010

Organometallic Chemistry in Non-Classical Environments

Paul Joseph Dyson

A summary of our on-going research on organometallic chemistry is provided with an emphasis on the function, reactivity and mechanisms of organometallic compounds in water, ionic liquids and in living systems. The role of organometallic compounds in both c ...

2011

Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound

Paul Joseph Dyson, Angela Casini

Electrospray ionisation mass spectrometry was used to analyze the reactions of metal compds. with mixts. of selected proteins. Three representative medicinally relevant compds., cisplatin, transplatin and the organometallic ruthenium compd. RAPTA-C, were r ...

Springer2009

Advances in the Rational Design of Rhodium Nanoparticle Catalysts: Control via Manipulation of the Nanoparticle Core and Stabilizer

Paul Joseph Dyson, Ning Yan, Yuan Yuan

This review describes some of the fascinating advances in the field of rhodium nanoparticle (NP) catalysis that have emerged in recent years. The examples described are categorized according to the research approach applied, involving either direct enginee ...

2012

Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin

Paul Joseph Dyson, Olivier Pierre Zava, Michael Groessl

The cellular uptake and subcellular distribution including adduct formation with genomic DNA and uptake into mitochondria of two ruthenium(III)-based drugs in clinical trials, KP1019 and NAMI-A, and cisplatin, was investigated in cisplatin sensitive and re ...

2011