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Paul Joseph Dyson

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Publications associées (669)

Enzyme inhibition by metal complexes: concepts, strategies and applications

Paul Joseph Dyson, Kelly Joan Kilpin

Metal complexes are increasingly being used to inhibit enzymes. The reasons for this increased interest arise from the special features that metal complexes offer, e.g. the facile construction of 3D architectures that tightly fill enzyme active sites incre ...

2013

The influence of RAPTA moieties on the antiproliferative activity of peripheral-functionalised poly(salicyladiminato) metallodendrimer

Paul Joseph Dyson, Catherine Marie Amélie Clavel

Cationic N,O-chelating dendrimers functionalised on the periphery with RAPTA-like (ruthenium(II)-arene-1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane) moieties have been synthesised and characterised using NMR and IR spectroscopy, elemental analysis and MAL ...

Royal Society of Chemistry2013

Platinum- and Ruthenium-Based Anticancer Compounds, Inhibition of Glutathione Transferase P1-1

Paul Joseph Dyson

Springer2013

Formation and Properties of Self-Assembly-Driven Fluorescent Nanoparticle Sensors

Paul Joseph Dyson, Zhaofu Fei

Fluorescent nanoparticles (FNPs) are obtained in water by self-assembly from a polymeric ionic liquid, fluorescent carboxylate moiety, and a surfactant through two main supramolecular interactions, that is, ionic bonds and hydrophobic/hydrophilic interacti ...

Wiley-Blackwell2013

The making of iLiquids - the chemist's equivalent of the iPhone

Paul Joseph Dyson, Zhaofu Fei

In this viewpoint we discuss the contributions from John S. Wilkes and Michael J. Zaworotko concerning the discovery of stable ionic liquids (ILs) and their accompanying structural studies (J. Chem. Soc., Chem. Commun., 1992, 965) and Robin D. Rogers and J ...

Royal Society of Chemistry2013

The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics

Paul Joseph Dyson, Angela Casini

DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molecular mechanisms of two established ruthenium-based antimetastatic agents, namely trans-[tetrachloro (DMSO) (imidazole)ruthenate(III)] (NAMI-A) and [Ru(eta(6 ...

Elsevier Science Inc2013

Heterogeneous Silica-Supported Ruthenium Phosphine Catalysts for Selective Formic Acid Decomposition

Gabor Laurenczy, Paul Joseph Dyson, Weijia Gan

The water-soluble ruthenium(II)–mTPPTS complex (mTPPTS= meta-trisulfonated triphenylphosphine) efficiently catalyzes the generation of hydrogen from formic acid in aqueous solution. This catalyst has been immobilized in a hydrophilic silica sup- port to fa ...

Wiley-VCH Verlag2013

Cytotoxicity of ruthenium-arene complexes containing B-ketoamine ligands

Rosario Scopelliti, Paul Joseph Dyson, Catherine Marie Amélie Clavel

New ruthenium(II) arene derivatives (arene = p-cymene, benzene, hexamethylbenzene) containing beta-ketoamine ligands L' (HL' in general; in detail, HLph,ph = (4Z)-3-methyl-4-((phenylamino)(phenyl)methylene)-1-phenyl-1H-pyrazol-5(4H)-one, HLnaph,ph = (4Z)-3 ...

American Chemical Society2013

Ruthenium(II)-Catalyzed Hydrogen Generation from Formic Acid using Cationic, Ammoniomethyl-Substituted Triarylphosphine Ligands

Gabor Laurenczy, Paul Joseph Dyson, Weijia Gan, Dennis Snelders

The selective catalytic decomposition of formic acid into hydrogen and carbon dioxide has been achieved in water under mild conditions. For the first time, a ruthenium ion in combination with series of oligocationic, ammoniomethyl-substituted triarylphosph ...

Wiley-VCH Verlag2013

Synthesis, Molecular Structure and Cytotoxicity of Molecular Materials Based on Water Soluble Half-Sandwich Rh(III) and Ir(III) Tetranuclear Metalla-Cycles

Paul Joseph Dyson, Benjamin Samuel Murray

The neutral dinuclear complexes [(eta(5)-C5Me5)(2)Rh-2(mu-dhnq)Cl-2] (1) and [(eta(5)-C5Me5)(2)Ir-2(mu-dhnq)Cl-2] (2) (dhnqH(2) = 5,8-dihydroxy-1,4-naphthoquinone) were obtained from the reaction of (eta(5)-C5Me5)M(mu-Cl)Cl (M = Rh, Ir) with dhnqH(2) ...

2013

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger, Alexey Nazarov, Michael Groessl, Muhammad Hanif

Ru-II(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour. ...

Royal Society of Chemistry2012

Fragmentation methods on the balance: unambiguous top–down mass spectrometric characterization of oxaliplatin–ubiquitin binding sites

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger

The interaction between oxaliplatin and the model protein ubiquitin (Ub) was investigated in a top-down approach by means of high-resolution electrospray ionization mass spectrometry (ESI-MS) using diverse tandem mass spectrometric (MS/MS) techniques, incl ...

Springer-Verlag2012

Click-Functionalized Ru(II) Complexes for Dye-Sensitized Solar Cells

Michael Graetzel, Shaik Mohammed Zakeeruddin, Paul Joseph Dyson, Nuttapol Pootrakulchote, Ryan Dykeman, Amaresh Mishra

Three heteroleptic ruthenium complexes incorporating new ancillary ligands synthesized by sequential connection of different alkyl functionalities with triazole as a linker are prepared using click chemistry. These sensitizers exhibit low-energy metal-to-l ...

Wiley-VCH Verlag Berlin2012

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Paul Joseph Dyson, Olivier Pierre Zava

Three generations of pyrenyl bis-MPA dendrimers with two different end-groups, acetonide (pyrG) or alcohol (pyr(Gn center dot OH)) (n = 1-3), were synthesized, and the pyrenyl group of the dendritic molecules was encapsulated in the arene ruthenium metalla ...

2012

Delivery of floxuridine derivatives to cancer cells by water-soluble organometallic-cages

Paul Joseph Dyson, Olivier Pierre Zava

The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene (pPr(i)C(6)H(4)Me) ruthenium building blocks and 2,5-dioxydo-1,4-benzoquinonato (dobq) or 5,8-dioxydo-1,4-naphthoquinonato (donq) bridges, in the presence of ...

American Chemical Society2012

Encapsulation of inorganic and organic guest molecules into an organometallic hexacationic arene osmium metalla-prism: Synthesis, characterisation and anticancer activity

Paul Joseph Dyson, Olivier Pierre Zava

The arene osmium metalla-prism (p-cymene)(6)Os-6(donq)(3)(tpt)(2) (2) (donq 5,8-dioxydo-1,4-naphthoquinonato, tpt 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine) has been prepared from the dinuclear arene osmium precursor [(p-cymene)(2)Os-2(donq)Cl-2] ...

Elsevier2012

Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors

Paul Joseph Dyson, Zhaofu Fei, Xianfu Zhang

Single walled carbon nanotubes (SWNTs) are emerging as promising delivery vehicles for cancer diagnostics and chemotherapies due to their unique properties, including, remarkable cell membrane penetrability, high drug-carrying capacities, pH-dependent ther ...

2012

Exploring the Versatility of Cycloplatinated Thiosemicarbazones as Antitumor and Antiparasitic Agents

Paul Joseph Dyson, Catherine Marie Amélie Clavel

Tridentate cycloplatinated thiosemicarbazone complexes have been prepared from a biologically significant ligand, 3,4-dichloroacetophenone thiosemicarbazone (1). The tetranuclear complex 2 was prepared by reaction of the ligand with K-2[PtCl4]. Two mononuc ...

Amer Chemical Soc2012

Thiolato-bridged arene-ruthenium complexes: synthesis, molecular structure, reactivity and anticancer activity of the dinuclear complexes [(arene)2Ru2(SR)2C12]

Paul Joseph Dyson, Olivier Pierre Zava

Treatment of an areneruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene)2Ru2(SR)3]+ was shown to proceed through the neutral thiolato complexes [(arene)2Ru2(SR)2Cl2], which have been isolated and charac ...

Wiley-Blackwell2012

Naphthalimide-tagged ruthenium-arene anticancer complexes: combining coordination with intercalation

Paul Joseph Dyson, Catherine Marie Amélie Clavel, Fabio Edafe, Kelly Joan Kilpin

Ruthenium(II) arene compounds have been modified with the naphthalimide group, tethered via the arene ligand, i.e. {dichloroeta(6)-N-(phenylalkyl)(4-dimethylamino)-1,8-naphthalimideruthenium(II)} (alkyl = methyl, ethyl, propyl, pta = 1,3,5-triaza-7- ...

American Chemical Society2012

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