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Paul Joseph Dyson

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Publications associées (669)

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Olivier Pierre Zava

Chemotherapeutics for the treatment of tumorigenic conditions that feature novel modes of action are highly sought after to overcome the limitations of current chemotherapies. Herein, we report the conjugation of the alkylating agent chlorambucil to the RA ...

2015

Increasing the selectivity of biologically active tetranuclear arene ruthenium assemblies

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Noelia Claude Herrero

A series of arene ruthenium metalla-rectangles of general formula (eta(6)-p-cymene)(4)Ru-4(mu(4)-embelin)(2)(mu(2)-N boolean AND N)(2)(4) was prepared from the embelin-derived metalla-clip (eta(6)-p-cymene)(2)Ru-2(mu(4)-embelin) Cl-2 (1), silver ...

Elsevier Science Sa2015

Higher generation cationic N,N-ruthenium(II)-ethylene-glycol-derived metallodendrimers: Synthesis, characterization and cytotoxicity

Paul Joseph Dyson, Tina Riedel

A new series of higher generation cationic N,N-chelating, ruthenium(II)-ethylene-glycol metallodendrimers from first-, second-, third- and fourth-generation pyridylimine-based poly(propylene) dendrimer scaffolds of the type, DAB-(NH2) (where n = 4, 8, 16 o ...

Elsevier Science Sa2015

High-performance dye-sensitized solar cell based on an electrospun poly(vinylidene fluoride-co-hexafluoropropylene)/cobalt sulfide nanocomposite membrane electrolyte

Paul Joseph Dyson, Zhaofu Fei

Electrospun poly(vinylidene fluoride-co-hexafluoropropylene) (PVdF-HFP) nanocomposite membranes incorporated with different weight percentages (1, 2 and 3 wt%) of cobalt sulfide (CoS) were prepared by an electrospinning technique. The surface morphology, c ...

Royal Soc Chemistry2015

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska

Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique w ...

2015

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

Paul Joseph Dyson, Thierry Buclin, Stewart Cole, Florence Pojer, Ruben Hartkoorn, Ming Zhang, Benoit Lechartier, Joao Pedro De Almeida Neres, Anthony Vocat

The benzothiazinone lead compound, BTZ043, kills Mycobacterium tuberculosis by inhibiting the essential flavo-enzyme DprE1, decaprenylphosphoryl-beta-D-ribose 2-epimerase. Here, we synthesized a new series of piperazine-containing benzothiazinones (PBTZ) a ...

2014

A novel platinum nanocatalyst for the oxidation of 5-Hydroxymethylfurfural into 2,5-Furandicarboxylic acid under mild conditions

Gabor Laurenczy, Paul Joseph Dyson, Zhaofu Fei, Duncan Thomas Lindsay Alexander, Ning Yan, Georgios Savoglidis, Sviatlana Siankevich

5-Hydroxymethylfurfural (HMF) is a key intermediate obtainable from various cellulosic (biomass) derivatives, but it must be converted to other chemicals such as 2,5-Furandicarboxylic acid (FDCA) for direct use. FDCA is an important derivative of HMF as it ...

Academic Press Inc Elsevier Science2014

Homogeneous Catalytic Dehydrogenation of Formic Acid: Progress Towards a Hydrogen-Based Economy

Gabor Laurenczy, Paul Joseph Dyson

One of the limiting factors to a hydrogen-based economy is associated with the problems storing hydrogen. Many different approaches are under evaluation and the optimum approach will not be the same for all applications, i.e., static, mobile, small and lar ...

2014

Potential of Cycloaddition Reactions To Generate Cytotoxic Metal Drugs In Vitro

Paul Joseph Dyson, Stéphanie Crot, Benjamin Samuel Murray, Sviatlana Siankevich

Severe general toxicity issues blight many chemotherapeutics utilized in the treatment of cancers, resulting in the need for more selective drugs able to exert their biological activity at only the required location(s). Toward this aim, we report the devel ...

Amer Chemical Soc2014

Ruthenium(II)-Arene RAPTA Type Complexes Containing Curcunnin and Bisdemethoxycurcumin Display Potent and Selective Anticancer Activity

Rosario Scopelliti, Paul Joseph Dyson, Tina Riedel

A series of novel ruthenium(II) arene RAPTA type derivatives (arene = cymene, hexamethylbenzene) containing curcumin-based ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and PTA (1,3,5-triaza-7-phosphaadamantane) have been synthesized and fully ...

2014

Synthesis, structural characterization and cytotoxicity of bimetallic chlorogold(I) phosphine complexes employing functionalized phosphinoferrocene carboxamides

Paul Joseph Dyson, Tina Riedel

Gold( I) phosphine complexes of the general formula [AuCl(Ph(2)PfcCONHY-kappa P)], where Y is CH2CO2Me (7), CH2CONH2 (8), CH2CH2OH (9), CH(CH2OH)(2) (10), C(CH2OH)(3) (11), and CH2SO3(HNEt3) (12), and fc is ferrocene-1,1'-diyl, were prepared from [AuCl(tht ...

Elsevier Science Sa2014

Neutral and cationic osmium(II)-arene metallodendrimers: Synthesis, characterisation and anticancer activity

Paul Joseph Dyson, Fabio Edafe

Two neutral and two cationic half-sandwich Os(II)-arene metallodendrimers, of general formula [DAB-PPI-{(eta(6)-p-cym)Os((C7H5NO)-kappa(2)-N,O)Cl}(n)] and [DAB-PPI-{(eta(6)-p-cym)Os((C6H5N2)-kappa(2)-N,N)Cl}(n)]PF6 (where n = 4 (G1) or 8 (G2)) have be ...

Elsevier Science Sa2014

Highly cytotoxic trithiolato-bridged dinuclear Rh(III) and Ir(III) complexes

Paul Joseph Dyson, Benjamin Samuel Murray

Water soluble trithiolato-bridged cationic complexes of the type (eta(5)-C5Me5)(2)M-2(mu-SC6H4-p-X)(3) (M = Rh, X = H, 1; CH3, 3; OCH3, 5; Pr-i, 7; Bu-t, 9; M Ir, X = H, 2; CH3, 4; OCH3, 6; Pr-i, 8; Bu-t, 10) were synthesized and isolated as their chl ...

Elsevier Science Sa2014

Strategy to Optimize the Biological Activity of Arene Ruthenium Metalla-Assemblies

Paul Joseph Dyson, Tina Riedel

Three new dinuclear arene ruthenium metalla-clips of the general formula [(p-cymene)(2)Ru2Cl2(mu-L)] have been prepared from {(p-cymene)(2)Ru2Cl2(p-Cl)(2)] and H2L organic linkers (H2La = diethyl-1,2-diazeneclicarboxylate, H2Lb = N,N'-bis(2-hydroxyethyl)ox ...

Amer Chemical Soc2014

Synthesis, Structure, and Antiproliferative Activity of Ruthenium(II) Arene Complexes with N,O-Chelating Pyrazolone-Based beta-Ketoamine Ligands

Rosario Scopelliti, Paul Joseph Dyson, Catherine Marie Amélie Clavel, Agnese Petrini

Novel ruthenium half-sandwich complexes containing (N,O)-bound pyrazolone-based beta-ketoamine ligands have been prepared, and the solid-state structures of one ligand and five complexes have been determined by single-crystal X-ray diffraction. Some of the ...

Amer Chemical Soc2014

Enhanced Conversion of Carbohydrates to the Platform Chemical 5-Hydroxymethylfurfural Using Designer Ionic Liquids

Gabor Laurenczy, Rosario Scopelliti, Paul Joseph Dyson, Zhaofu Fei, Ning Yan, Sviatlana Siankevich

5-Hydroxymethylfurfural (HMF) is a key platform chemical that may be obtained from various cellulosic (biomass) derivatives. Previously, it has been shown that ionic liquids (ILs) facilitate the catalytic conversion of glucose into HMF. Herein, we demonstr ...

Wiley-V C H Verlag Gmbh2014

Ruthenium clusters as new class of anti-angiogenic agent

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Alexey Nazarov

Springer2014

Amide bond formation via C(sp(3))-H bond functionalization and CO insertion

Gabor Laurenczy, Paul Joseph Dyson, Ning Yan, Huizhen Liu

An efficient method for the synthesis of amides via Pd-catalyzed oxidative carbonylation of C(sp(3))-H bonds with CO and amines is described. The route efficiently provides substituted phenyl amides from alkanes. ...

Royal Society of Chemistry2014

Combination of low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy in human carcinoma models: lack of vascular normalization

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin

Springer2014

Low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy for cancer: lack of vascular normalization

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin

Photodynamic therapy (PDT) is an effective clinical treatment for a number of different cancers. PDT can induce hypoxia and inflammation, pro-angiogenic side effects, which may counteract its angio-occlusive mechanism. The combination of PDT with anti-angi ...

2014

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