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Paul Joseph Dyson

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Publications associées (669)

Dicationic Ruthenium(II)-Arene-Curcumin Complexes Containing Methylated 1,3,5-Triaza-7-phosphaadamantane: Synthesis, Structure, and Cytotoxicity

Rosario Scopelliti, Paul Joseph Dyson, Tina Riedel

Dicationic ruthenium(II)-p-cymene complexes containing curcumin ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and ionic N-methyl-1,3,5-triaza-7-phosphaadamantane [PTA-Me]X (X = BF4 or I) have been synthesized and fully characterized for the fi ...

Wiley-Blackwell2017

Perfluorinated HDAC inhibitors as selective anticancer agents

Paul Joseph Dyson, Tina Riedel

A series of potent histone deacetylase inhibitors is presented that incorporate alkyl or perfluorinated alkyl chains. Several new compounds show greater in vitro antiproliferative activity than the clinically approved inhibitor, SAHA. Furthermore, the new ...

Royal Society of Chemistry2017

The Differential Distribution of RAPTA-T in Non-Invasive and Invasive Breast Cancer Cells Correlates with Its Anti-Invasive and Anti-Metastatic Effects

Paul Joseph Dyson, Graham Knott, Anders Meibom, Stéphane Laurent Escrig, Gianni Sava, Catherine Maclachlan

Nanoscale secondary ion mass spectrometry (NanoSIMS) combined with transmission electron microscopy (TEM) can be a powerful approach to visualize the exact distribution of drugs at the sub-cellular level. In this work, we exploit this approach to identify ...

2017

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

Paul Joseph Dyson, Benjamin Samuel Murray, Tina Riedel

The 'acidic patch' is a highly electronegative cleft on the histone H2A-H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially therapeutic site with exogenous ...

Nature Research2017

Repositioning approved drugs for the treatment of problematic cancers using a screening approach

Gerardo Turcatti, Damiano Banfi, Paul Joseph Dyson, Fabien Kuttler, Hristo Plamenov Varbanov

Advances in treatment strategies together with an earlier diagnosis have considerably increased the average survival of cancer patients over the last four decades. Nevertheless, despite the growing number of new antineoplastic agents introduced each year, ...

2017

Synthesis and In Vitro (Anticancer) Evaluation of eta(6)-Arene Ruthenium Complexes Bearing Stannyl Ligands

Paul Joseph Dyson, Tina Riedel

Treatment of the known half-sandwich complexes of the type [(eta(6)-C6H6)RuCl2(P(OR)(3))] (R = Me or Ph) with SnCl2 yielded three new half-sandwich ruthenium complexes (C1-C3): [(eta(6)-C6H6)RuCl(SnCl3)(P(OMe)(3))] (C1), [(eta(6)-C6H6)RuCl(SnCl3)(P(OPh)(3) ...

2017

Biochemical and biophysical characterization of ruthenation of BRCA1 RING protein by RAPTA complexes and its E3 ubiquitin ligase activity

Luc Patiny, Paul Joseph Dyson, Laure Menin

RAPTA compounds, ([Ru(eta(6)-arene)(PTA)Cl-2], PTA = 1,3,5-triaza-7-phosphaadamantane), have been reported to overcome drug resistance in cisplatin resistant cells. However, the exact mechanism of these complexes is still largely unexplored. In this study, ...

Elsevier2017

New highly cytotoxic organic and organometallic bexarotene derivatives

Paul Joseph Dyson, Alexey Nazarov, Mathurin Baquié

A series of bifunctional ruthenium(II) arene compounds modified with bexarotene, a retinoid that selectively activates retinoid X receptors inducing cell differentiation and apoptosis and preventing drug resistance, are described. The bexarotene is tethere ...

Elsevier2017

Oxaliplatin reacts with DMSO only in the presence of water

Paul Joseph Dyson, Laure Menin, Hristo Plamenov Varbanov

Herein we show that oxaliplatin reacts rapidly with DMSO in aqueous solutions, despite being stable in pure DMSO and pure water. Furthermore, the reactivity of the clinically applied Pt(II) drugs in water/DMSO and PBS/DMSO mixtures, and the nature of the s ...

2017

Expression proteomics study to determine metallodrug targets and optimal drug combinations

Kai Johnsson, Paul Joseph Dyson, David Hacker, Claire Samantha Allardyce

The emerging technique termed functional identification of target by expression proteomics (FITExP) has been shown to identify the key protein targets of anti-cancer drugs. Here, we use this approach to elucidate the proteins involved in the mechanism of a ...

Nature Research2017

Polyimidazolium Salts: Robust Catalysts for the Cycloaddition of Carbon Dioxide into Carbonates in Solvent-Free Conditions

Paul Joseph Dyson, Zhaofu Fei, Felix Daniel Bobbink, Wei Zhong

There is a growing interest in sustainable heterogeneous catalysts based on organic polymers. Here, we describe a series of polyimidazolium salt catalysts, prepared from the direct reaction of arene- bridged bis- and tris-alkyl halides with trimethylsilyli ...

Wiley-V C H Verlag Gmbh2017

Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes

Rosario Scopelliti, Paul Joseph Dyson, Emilia Paunescu, Mylène Soudani, Lucinda Kate Batchelor

Dinudear metal complexes have emerged as a promising class of anticancer compounds with the ability to cross-link biomolecular targets. Here, we describe two novel series of phosphine-linked dinudear ruthenium(II) p-cyrnene and gold(I) complexes, in which ...

2017

An efficient Pt nanoparticle–ionic liquid system for the hydrodeoxygenation of bio-derived phenols under mild conditions

Gabor Laurenczy, Paul Joseph Dyson, Zhaofu Fei, Cornel Fink, Lu Chen

Platinum nanoparticles (NPs) were synthesized in situ in the ionic liquid (IL) [Emim]NTf2 (1-ethyl-3- methylimidazolium bis(trifluoromethylsulfonyl)imide) as well as in mixtures of [Emim]NTf2 with a second IL, Lewis acid or Brønsted acid, but in the absenc ...

Royal Society of Chemistry2017

Bilayered polyurethane/dipole-dipole and H-bonding interaction reinforced hydrogels as thermo-responsive soft manipulators

Paul Joseph Dyson, Zhaofu Fei, Zhangjun Huang, Haiyan Jia, Xunhui Wang

Dipole-dipole and hydrogen-bonding interaction reinforced (DHIR) hydrogels that demonstrate both excellent thermo-responsive volume change and high mechanical strength have been developed. Their thermo-responsive volume change originates from the balance b ...

Royal Society of Chemistry2017

Cytotoxic Half-Sandwich Rh(III) and Ir(III) beta-Diketonates

Rosario Scopelliti, Paul Joseph Dyson, Tina Riedel, Agnese Petrini

A series of half-sandwich pentamethylcyclopentadienyl rhodium(III) and iridium(III) complexes [CpM(DBM/ HDB/AVB)Cl] and [CpM(DBM/HDB/AVB)(PTA)]-[SO3CF3], where Cp* = pentamethylcyclopentadienyl, the proligands DBMH = dibenzoylmethane, HDBH = o-hydroxydi- ...

American Chemical Society2017

Thiazolium carbene catalysts for the fixation of CO2 onto amines

Paul Joseph Dyson, Safak Bulut, Felix Daniel Bobbink, Mylène Soudani, Shoubhik Das

The catalytic N-formylation and N-methylation of amines using CO2 as the carbon source represents a facile and sustainable approach for the synthesis of pharmaceuticals and natural products. Herein, we describe highly effective and inexpensive thiazolium c ...

Royal Society of Chemistry2016

Regulating the anticancer properties of organometallic dendrimers using pyridylferrocene entities: synthesis, cytotoxicity and DNA binding studies

Paul Joseph Dyson, Tina Riedel

A new series of eight first- and second-generation heterometallic ferrocenyl-derived metal-arene metallodendrimers, containing ruthenium(II) p-cymene, ruthenium(II)-hexamethylbenzene, rhodium(III)-cyclopentadienyl or iridium(III)-cyclopentadienyl moieties ...

2016

New Insights Into the Role of Imidazolium-Based Promoters for the Electroreduction of CO2 on a Silver Electrode

Michael Graetzel, Rosario Scopelliti, Paul Joseph Dyson, Marcel Roland Schreier, Pui Shan Genevieve Lau, Dmitry Vasilyev

The electrochemical reduction of CO2 to CO is a reaction of central importance for sustainable energy conversion and storage. Herein, structure activity relationships of a series of imidazolium-based cocatalysts for this reaction are described, which demon ...

Amer Chemical Soc2016

The development of RAPTA compounds for the treatment of tumors

Paul Joseph Dyson, Christian Hartinger, Benjamin Samuel Murray

Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has b ...

Elsevier Science Sa2016

p,t-[Ru(CO)(PR3)(tren)](2+) [R=Ph or p-tol; tren=tris(2-aminoethyl)amine], Ru(II) complexes bearing a simple tripodal tetradentate amine: synthesis, characterization, and antimicrobial activity

Rosario Scopelliti, Paul Joseph Dyson, Francisco Dinis Fagundes

Complexes with general formula p,t-[Ru(CO)(PR3)(tren)]X-2 [R=Ph (1) or p-tol (2); tren=tris(2-aminoethyl)amine; X=Cl- or PF6-] were prepared from [RuCl2(CO)(dmf)(PR3)] by direct reaction with tren. The complexes were fully characterized by NMR (H-1, P-31{H ...

Taylor & Francis2016

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