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Paul Joseph Dyson

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Publications associées (669)

Frustrated Lewis pair-mediated fixation of CO2 within a metal-organic framework

Paul Joseph Dyson, Kyriakos Stylianou, Arunraj Chidambaram, Serhii Shyshkanov, Ngoc Tú Nguyên

Finding pragmatic solutions to curb the accumulation of atmospheric CO2 and tackle the associated greenhouse effect is challenging. Herein, we demonstrate the use of an in situ formed frustrated Lewis pair (FLP) within a metal-organic framework (MOF) to ef ...

Royal Society of Chemistry2019

The rise of 3D cellular spheroids: efficient culture via upward growth from a superamphiphobic surface

Paul Joseph Dyson

Oxford University Press (OUP)2019

Retarding Thermal Degradation in Hybrid Perovskites by Ionic Liquid Additives

Mohammad Khaja Nazeeruddin, Mounir Driss Mensi, Paul Joseph Dyson, Zhaofu Fei, Felix Daniel Bobbink, Marius Franckevicius, Cristina Roldán Carmona, Nikita Drigo, Zhangjun Huang, Rui Xia

Recent years have witnessed considerable progress in the development of solar cells based on lead halide perovskite materials. However, their intrinsic instability remains a limitation. In this context, the interplay between the thermal degradation and the ...

2019

Oxidative cleavage of -O-4 bonds in lignin model compounds with a single-atom Co catalyst

Paul Joseph Dyson, Zhaofu Fei, Xile Hu, Antoine Philippe Van Muyden, Lichen Bai, Zhangjun Huang, Sijie Liu, Xinjiang Cui, Xiang Li

Single-atom catalysts are emerging as primary catalysts for many reactions due to their 100% utilization of active metal centers leading to high catalytic efficiencies. Herein, we report the use of a single-atom Co catalyst for the oxidative cleavage of th ...

2019

Inkjet-Printed Mesoporous TiO2 and Perovskite Layers for High Efficiency Perovskite Solar Cells

Hubert Girault, Mohammad Khaja Nazeeruddin, Paul Joseph Dyson, Emad Oveisi, Andreas Stephan Lesch, Yonghui Lee, Victor Costa Bassetto, Sanghyun Paek, Aron Joel Huckaba, Rui Xia

Perovskite solar cells with mesoporous TiO2 electron transport layers have previously reached >22 % efficiency at the laboratory scale (

2019

Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis

Gerardo Turcatti, Damiano Banfi, Paul Joseph Dyson, Fabien Kuttler, Hristo Plamenov Varbanov

Drug combinations are extensively used to treat cancer and are often selected according to complementary mechanisms. Here, we describe a cell-based high-throughput screening assay for identification of synergistic combinations between broadly applied plati ...

2019

Sustainable, Reshapable Surfactant-Polyelectrolyte Plastics Employing Water as a Plasticizer

Paul Joseph Dyson, Zhaofu Fei, Antoine Philippe Van Muyden, Zhangjun Huang, Haiyan Jia

Natural polymers such as those present in foods contain abundant noncovalent intra- and intermolecular interactions, notably hydrogen bonds, which make them rigid when dry, but on exposure to water soften, due to disruption of these interactions. This soft ...

2019

Cellular responses of BRCA1-defective HCC1937 breast cancer cells induced by the antimetastasis ruthenium(II) arene compound RAPTA-T

Paul Joseph Dyson

An organometallic ruthenium(II) arene compound, Ru((6)-toluene)(PTA)Cl-2 (PTA=1,3,5-triaza-7-phosphaadamantane), termed RAPTA-T, exerts promising antimetastatic properties. In this study, the effects of RAPTA-T on BRCA1-defective HCC1937 breast cancer cell ...

SPRINGER2019

The dilemma between acid and base catalysis in the synthesis of benzimidazole from o-phenylenediamine and carbon dioxide

Paul Joseph Dyson, Martin Hulla, Simon Nussbaum, Alexy Robert Bonnin

The tandem synthesis of benzimidazole and other azoles can be achived by the N-formylation of ortho-substituted anilines followed by a cyclization reaction. However, CO2-based N-formylations with hydrosilane reducing agents are base catalyzed whereas the c ...

Royal Society of Chemistry2019

Histidine Targeting Heterobimetallic Ruthenium(II)-Gold(I) Complexes

Paul Joseph Dyson, Daniel Ortiz Trujillo, Lucinda Kate Batchelor

Inspired by the preferential, allosteric binding of RAPTA-T and auranofin to the nucleosome core particle, we describe the design and synthesis of a series of heterobimetallic ruthenium(II)-gold(I) complexes with varying spacer lengths ranging from four to ...

2019

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. "Alive, with good vision and no comorbidity"

Paul Joseph Dyson

Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary aims. Historically, enucleation was the first successful therapeutic ap ...

PERGAMON-ELSEVIER SCIENCE LTD2019

Heterobimetallic Ru(mu-dppm)Fe and homobimetallic Ru(mu-dppm)Ru complexes as potential anti-cancer agents

Paul Joseph Dyson, Lucinda Kate Batchelor

Two heterobimetallic mu-dppm bridged Fe,Ru complexes, [(eta(6)-Arene)RuCl2(mu-dppm)Fe(CO)I(eta(5)-C5H5)] (Ar - C6H6 (1) and p-cymene (2), dppm-1,1-bis(diphenylphosphino)methane) were obtained in a facile reaction between [Fe(eta(5)-C5H5)I(CO)(kappa(1)-dppm ...

2019

Anticancer Potential of Diiron Vinyliminium Complexes

Paul Joseph Dyson, Lucinda Kate Batchelor, Silvia Schoch

Although ferrocene derivatives have attracted considerable attention as possible anticancer agents, the medicinal potential of diiron complexes has remained largely unexplored. Herein, we describe the straightforward multigram-scale synthesis and the antip ...

WILEY-V C H VERLAG GMBH2019

In Situ Formation of Frustrated Lewis Pairs in a Water-Tolerant Metal-Organic Framework for the Transformation of CO2

Paul Joseph Dyson, Fatmah Ebrahim, Kyriakos Stylianou, Serhii Shyshkanov, Ngoc Tú Nguyên

Frustrated Lewis pairs (FLPs) consist of sterically hindered Lewis acids and Lewis bases, which provide high catalytic activity towards non-metal-mediated activation of "inert" small molecules, including CO2 among others. One critical issue of homogeneous ...

Wiley-VCH Verlag GmbH2019

A General and Facile Approach for the Electrochemical Reduction of Carbon Dioxide Inspired by Deep Eutectic Solvents

Paul Joseph Dyson, Dmitry Vasilyev

Deep eutectic solvents (DESs) were applied to the electrochemical CO2 reduction reaction (CO2RR). Choline-based DESs represent a non-toxic and inexpensive alternative to room-temperature ionic liquids (RTILs) as additives to the system or as electrolyte. F ...

2019

Crosslinking Allosteric Sites on the Nucleosome

Paul Joseph Dyson, Ursula Röthlisberger, Thibaud Edouard Alistair von Erlach, Lucinda Kate Batchelor

Targeting defined histone protein sites in chromatin is an emerging therapeutic approach that can potentially be enhanced by allosteric effects within the nucleosome. Here we characterized a novel hetero-bimetallic compound with a design based on a nucleos ...

Wiley-VCH Verlag GmbH2019

Inexpensive Hole-Transporting Materials Derived from Troger's Base Afford Efficient and Stable Perovskite Solar Cells

Mohammad Khaja Nazeeruddin, Paul Joseph Dyson, Zhaofu Fei, Cristina Roldán Carmona, Rui Xia, Maria Cristina Momblona Rincón

The synthesis of three enamine hole-transporting materials (HTMs) based on Troger's base scaffold are reported. These compounds are obtained in a three-step facile synthesis from commercially available materials without the need of expensive catalysts, ine ...

Wiley-VCH Verlag GmbH2019

Recent Considerations in the Application of RAPTA-C for Cancer Treatment and Perspectives for Its Combination with Immunotherapies

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Magdalena Rausch

The organometallic ruthenium(II) [Ru(arene)Cl2PTA] PTA - 1,3,5-triaza-7-phosphaadamantane compound, RAPTA-C, represents an innovative anti-cancer therapeutic and a better-tolerated alternative to platinum (Pt)-based chemotherapeutic drugs in the treatment ...

WILEY2019

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Paul Joseph Dyson, Wee Han Ang, Laure Menin

Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its use is restricted by side effects and/or by intrinsic or acquired drug resistance. Here, we ...

National Academy of Sciences2019

Selective, Fast-Response, and Regenerable Metal-Organic Framework for Sampling Excess Fluoride Levels in Drinking Water

Paul Joseph Dyson, Fatmah Ebrahim, Kyriakos Stylianou, Andrzej Gladysiak, Serhii Shyshkanov, Ngoc Tú Nguyên, Patrick Favre

Prolonged consumption of water contaminated with fluoride ions (F-) at concentrations exceeding 1.5 ppm can lead to considerable health implications, particularly in children and developing embryos. With irreversible and potentially severe forms of fluorid ...

2019

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