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Jeffrey Alan Hubbell

Cette personne n’est plus à l’EPFL

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Publications associées (229)

Engineered fibrin based scaffolds for urological tissue engineering applications

Jeffrey Alan Hubbell, Peter Frey, Elif Vardar

Wiley-Blackwell2014

Device design and materials optimization of conformal coating for islets of Langerhans

Jeffrey Alan Hubbell, Alice Anna Tomei

Encapsulation of islets of Langerhans may represent a way to transplant islets in the absence of immunosuppression. Traditional methods for encapsulation lead to diffusional limitations imposed by the size of the capsules (600-1,000 m in diameter), which r ...

National Academy of Sciences2014

Normalization and Accelerated Stabilization of VEGF-Induced Angiogenesis by Co-Delivery of Engineered PDGF-BB and VEGF Proteins From Fibrin Matrices

Mikaël Martino, Jeffrey Alan Hubbell, Veronica Sacchi

Nature Publishing Group2014

Materials and protein engineering approaches for modulating immunity

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Marie Ballester, Stephane Kontos, Kristen Lorentz, Alizée Jéléna Grimm, Laura Jeanbart, David Scott Wilson, Kym Lorenz Brünggel

Amer Chemical Soc2014

Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment

Mikaël Martino, Jeffrey Alan Hubbell

While human bone morphogenetic protein-2 (rhBMP-2) is a promising growth factor for bone regeneration, its clinical efficacy has recently shown to be below expectation. In order to improve the clinical translation of rhBMP-2, there exists strong motivation ...

Elsevier2013

Peripherally Administered Nanoparticles Target Monocytic Myeloid Cells, Secondary Lymphoid Organs and Tumors in Mice

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Stephane Kontos, Iraklis Kourtis, Sachiko Hirosue

Nanoparticles have been extensively developed for therapeutic and diagnostic applications. While the focus of nanoparticle trafficking in vivo has traditionally been on drug delivery and organ-level biodistribution and clearance, recent work in cancer biol ...

Public Library of Science2013

Investigating the acoustic release of doxorubicin from targeted micelles

Jeffrey Alan Hubbell

The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable of minimizing the adverse side ...

Elsevier2013

A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening

Jeffrey Alan Hubbell, Sebastian Maerkl, Armando Stano, Jose Luis Garcia Cordero

Large-scale experimentation is becoming instrumental in enabling new discoveries in systems biology and personalized medicine. We developed a multiplexed high-throughput nanoimmunoassay chip capable of quantifying four biomarkers in 384 5 nL samples, for a ...

Royal Soc Chemistry2013

Tissue, cell and engineering

Jeffrey Alan Hubbell

Current Biology Ltd2013

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Marie Ballester, Ziad Julier, Laura Jeanbart

In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via ultrasmall polymeric nanoparticles (NPs), which rapidly drain to the LN after int ...

National Academy of Sciences2013

Fibronectin Binding Modulates CXCL11 Activity and Facilitates Wound Healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Marco Pisano, Federico Tortelli

Engineered biomatrices offer the potential to recapitulate the regenerative microenvironment, with important implications in tissue repair. In this context, investigation of the molecular interactions occurring between growth factors, cytokines and extrace ...

Public Library of Science2013

Nanpoarticle based intradermal formulation targeting DC skin subsets to increase vaccine potency against HIV-1

Jeffrey Alan Hubbell, Sachiko Hirosue

Nature Publishing Group2013

Silk Hydrogels as Soft Substrates for Neural Tissue Engineering

Jeffrey Alan Hubbell, Federico Tortelli, Amy Marie Hopkins

There is great need for soft biomaterials that match the stiffness of human tissues for tissue engineering and regeneration. Hydrogels are frequently employed for extracellular matrix functionalization and to provide appropriate mechanical cues. It is chal ...

Wiley-V C H Verlag Gmbh2013

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

Matthias Lütolf, Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Adrian Ranga

By binding growth factors (GFs), the ECM tightly regulates their activity. We recently reported that the heparin-binding domain II of fibronectin acts as a promiscuous high-affinity GF-binding domain. Here we hypothesized that fibrin, the provisional ECM d ...

National Academy of Sciences2013

In situ cell manipulation through enzymatic hydrogel photopatterning

Matthias Lütolf, Mikaël Martino, Jeffrey Alan Hubbell, Katarzyna Mosiewicz, Martin Ehrbar, Laura Kolb

The physicochemical properties of hydrogels can be manipulated in both space and time through the controlled application of a light beam. However, methods for hydrogel photopatterning either fail to maintain the bioactivity of fragile proteins and are thus ...

Nature Publishing Group2013

VEGFR-3 Neutralization Inhibits Ovarian Lymphangiogenesis, Follicle Maturation, and Murine Pregnancy

Jeffrey Alan Hubbell, Melody Swartz, Jong Eun Ihm, Joseph Rutkowski, Miriella Carmela Pasquier, Didier Trono, Seung Tae Lee, Witold Waldemar Kilarski, Vivianne Greenwood

Lymphatic vessels surround follicles within the ovary, but their roles in folliculogenesis and pregnancy, as well as the necessity of Lymphangiogenesis in follicle maturation and health, are undefined. We used systemic delivery of mF4-31C1, a specific anta ...

Elsevier Science Inc2013

Preparation of Well-Defined Ibuprofen Prodrug Micelles by RAFT Polymerization

Jutta Christine Wandrey, Jeffrey Alan Hubbell, Urara Hasegawa

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat acute pain, fever, and inflammation and are being explored in a new indication in cancer. Side effects associated with long-term use of NSAIDs such as gastrointestinal damage and elevat ...

American Chemical Society2013

Engineering the Regenerative Microenvironment with Biomaterials

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Jeffrey James Rice, Federico Tortelli

Modern synthetic biomaterials are being designed to integrate bioactive ligands within hydrogel scaffolds for cells to respond and assimilate within the matrix. These advanced biomaterials are only beginning to be used to simulate the complex spatio-tempor ...

Wiley-Blackwell2013

A feeder-free, defined three-dimensional polyethylene glycol-based extracellular matrix niche for culture of human embryonic stem cells

Jeffrey Alan Hubbell, Seung Tae Lee, Jinhyun Kim

We report optimization of a serum- and feeder-free, three-dimensional (3D) niche created with a synthetic polyethylene glycol (PEG)-based extracellular matrix for self-renewal of human embryonic stem cells (hESCs). Three hESC lines (H9, H1 and Novo) were c ...

Elsevier Sci Ltd2013

Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles

Jeffrey Alan Hubbell, Melody Swartz, Armando Stano, Karen Dane

Using poly(propylene sulfide) (PPS) and poly(ethylene glycol) (PEG) as components of a nanocarrier platform, we sought to compare immune responses induced by PPS-bl-PEG polymersomes (PSs; watery-core structures, with antigen incorporated within the PSs) an ...

Elsevier Sci Ltd2013

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