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Jeffrey Alan Hubbell

Cette personne n’est plus à l’EPFL

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Publications associées (229)

Novel 7-mer peptide mediates nuclear targeting in MCF7 breast cancer cells

Jeffrey Alan Hubbell, Andrija Finka

2009

Phototocatalytic Lithography of Poly(propylene sulfide) Block Copolymers: Toward High-Throughput Nanolithography for Biomolecular Arraying Applications

Jeffrey Alan Hubbell

Photocatalytic lithography (PCL) is an inexpensive, fast, and robust method of oxidizing surface chemical moieties to produce patterned substrates. This technique has utility in basic biological research as well as various biochip applications. We report o ...

2009

Cell-responsive hydrogel for encapsulation of vascular cells

Jeffrey Alan Hubbell

The in vitro potential of a synthetic matrix metalloproteinase (MMP)-responsive poly(ethylene glycol) (PEG)-based hydrogel as a bioactive co-encapsulation system for vascular cells and a small bioactive peptide, thymosin beta 4 (T beta 4), was examined. We ...

2009

Superparamagnetic Nanoparticles as a Powerful Systems Biology. Characterization Tool in the Physiological Context

Heinrich Hofmann, Alke Fink, Jeffrey Alan Hubbell, Benedikt Steitz, Conlin O'Neil, Marc Moniatte, Andrija Finka, Jatuporn Salaklang

Recently, functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have been utilized for protein separation and therapeutic delivery of DNA and drugs. The development of new methods and tools for the targeting and identification of specific biom ...

Wiley-Blackwell2008

Dielectrophoresis-based particle exchanger for the manipulation and surface functionalization of particles

Heinrich Hofmann, Philippe Renaud, Nicolas Demierre, Raphaël Tornay, Jeffrey Alan Hubbell, Thomas Michael Braschler, Benedikt Steitz, Andrija Finka

We present a microfluidic device where micro- and nanoparticles can be continuously functionalized in flow. This device relies on an element called particle exchanger, which allows for particles to be taken from one medium and exposed to some reagent while ...

2008

Compressed collagen-PLA hybrids as scaffold for human bladder cells

Florian Maria Wurm, Jeffrey Alan Hubbell, Peter Frey

2008

Fibrin delivery systems for elastic tissue regeneration

Lirong Yang, Jeffrey Alan Hubbell, Thomas Barker, Peter Frey

2008

Bioactive poly(ethylene glycol) hydrogels for modulation of the smooth muscle cell phenotype

Jeffrey Alan Hubbell, Peter Frey

2008

The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype

Jeffrey Alan Hubbell, Peter Frey

The formation of scar tissue due to dedifferentiation of smooth muscle cells (SMCs) is one of the major issues faced when engineering bladder tissue. Furthermore, cell sources for regenerating the SMC layer are also limiting. Here we explore if human mesen ...

2008

RAFT homo- and copolymerization of N-acryloyl-morpholine, piperidine, and azocane and their self-assembled structures

Jeffrey Alan Hubbell, Yun Suk Jo, Jay Gantz, Davide Demurtas

We present new polymeric amphiphiles derived from N-acryloyl derivatives of the cyclic secondary amines: morpholine, piperidine, and azocane polymerized by reversible addition -fragmentation transfer (RAFT) polymerization. Both homopolymerization and block ...

American Chemical Society2008

Porphyrin-based photocatalytic lithography

Jeffrey Alan Hubbell

Photocatalytic lithography couples light with photoreactive coated mask materials to pattern surface chemistry. We excite porphyrins to create radical species that photocatalytically oxidize, and thereby pattern, chemistries in the local vicinity. The tech ...

2008

Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage

Jeffrey Alan Hubbell, Conlin O'Neil, Dominique André Rothenfluh

The extracellular matrix of dense, avascular tissues presents a barrier to entry for polymer-based therapeutics, such as drugs encapsulated within polymeric particles. Here, we present an approach by which polymer nanoparticles, suffciently small to enter ...

Nature Publishing Group2008

Expression and purification of recombinant aprotinin for enhanced stability of fibrin biomaterials

Jeffrey Alan Hubbell, Peter Frey, Kristen Lorentz

2008

Part II: Fibroblasts preferentially migrate in the direction of principal strain

Matthias Lütolf, Jeffrey Alan Hubbell

A growing body of evidence suggests that the sensory information from the cytoskeleton and integrins may be responsible for guiding migration during mechano- and haptotaxis. However, the dual function of these subcellular structures as mechano-sensors and ...

Springer-Verlag2008

PEG-b-PPS diblock copolymer aggregates for hydrophobic drug solubilization and release: Cyclosporin A as an example

Jeffrey Alan Hubbell, Davide Demurtas

Micelles formed from amphiphilic block copolymers have been explored in recent years as carriers for hydrophobic drugs. In an aqueous environment, the hydrophobic blocks form the core of the micelle, which can host lipophilic drugs, while the hydrophilic b ...

2008

Breakdown kinetics of aggregates from poly(ethylene glycol-bl-propylene sulfide) di- and triblock copolymers induced by a non-ionic surfactant

Jeffrey Alan Hubbell

We explored the effects of addition of the nonionic surfactant Triton X-100 on the stability of aggregates of poly(ethylene glycol-bl-propylene sulfide) di- and triblock copolymers. Fluorescence spectra of pyrene, used as a probe molecule, elucidated the v ...

2008

Lymphatic drainage function and its immunological implications: From dendritic cell homing to vaccine design

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

The slow interstitial flow that drains fluid from the blood capillaries into the lymphatic capillaries provides transport of macromolecular nutrients to cells in the interstitium. We discuss herein how this flow also provides continuous access to immune ce ...

Elsevier2008

Novel cell-seeded, tubular-shaped and highly dense collagen gel for tissue engineering

Lionel Ambroise Micol, Jeffrey Alan Hubbell, Peter Frey

2008

Coating hydrophobic surfaces with amphiphilic thioethers to reduce protein adsorption and cell adhesion

Nicola Tirelli, Jeffrey Alan Hubbell

The present invention provides methods and apparatus for coating surfaces with specially designed thioethers and amphiphilic thioethers that reduce protein adsorption and/or cell adhesion. This reduction may be achieved, for example, by controlling the spa ...

2008

Micropatterning of gold substrates based on poly(propylene sulfide-bl-ethylene glycol), (PPS-PEG) background passivation and the molecular-assembly patterning by lift-off (MAPL) technique

Jeffrey Alan Hubbell

Poly(propylene sulfide-bl-ethylene glycol) (PPS-PEG) is an amphiphilic block copolymer that spontaneously adsorbs onto gold from solution. This results in the formation of a stable polymeric layer that renders the surface protein-resistant when an appropri ...

2008

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