A combined strategy using bioluminescence imaging, bone densitometry and histology was used to analyze the bone regeneration capacity of human bone marrow (hBMSC) and adipose tissue (hAMSC) mesenchymal stem cells, seeded in an osteoconductive arginine-glyc ...

2008

Biofunctional materials in tissue repair and immunotherapeutics

Jeffrey Alan Hubbell, Melody Swartz

2008

Polypeptide ligands for targeting cartilage and methods of use thereof

Jeffrey Alan Hubbell, Dominique André Rothenfluh

Ligands that specifically bind to articular cartilage tissues are disclosed, including uses for targeting therapeutics towards articular cartilage tissue and new materials for articular cartilage. The ligands are effective in vivo to target therapeutic mat ...

2008

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability

Mikaël Martino, Jeffrey Alan Hubbell, Thomas Barker, Dominique André Rothenfluh, Mayumi Mochizuki Martino

The extracellular matrix (ECM) exerts powerful control over many cellular phenomena, including stem cell differentiation. As such, design and modulation of ECM analogs to ligate specific integrin is a promising approach to control cellular processes in vit ...

Elsevier2008

Functionalization of polysulfide nanoparticles and their performance as circulating carriers

Nicola Tirelli, Annemie Rehor, Jeffrey Alan Hubbell

We here present an evaluation of the carrier performance of nanoparticles that are biofunctional, i.e. derivatized to provide a controlled biological activity, and environmentally responsive, since they respond to the presence of oxidants. In particular, w ...

2008

Part I: A novel in-vitro system for simultaneous mechanical stimulation and time-lapse microscopy in 3D

Jeffrey Alan Hubbell

To investigate the migration response of cells to changes in their biophysical environment, a novel uniaxial cell stimulation device (UCSD) has been designed and tested. The device is capable of applying very precise user-defined static or dynamic mechanic ...

Springer-Verlag2008

The role of actively released fibrin-conjugated VEGF for VEGF receptor 2 gene activation and the enhancement of angiogenesis

Jeffrey Alan Hubbell, Martin Ehrbar

A major challenge for therapeutic delivery of angiogenic agents such as vascular endothelial growth factor (VEGF) is to achieve sustained, low dose signaling leading to durable neovessel formation. To this end, we recently created a variant of VEGF(121), T ...

2008

Artificial extracellular matrices for bone tissue engineering

Matthias Lütolf, Jeffrey Alan Hubbell, Martin Ehrbar, Simone Rizzi

2008

Cellular matrices - Physiology in microfluidics

Jeffrey Alan Hubbell

2008

Controlled Release Drug Coatings on Flexible Neural Probes

Philippe Renaud, Arnaud Bertsch, Jeffrey Alan Hubbell, André Mercanzini, Philippe Colin, Jean-Charles Bensadoun

We present the development, characterization and in vivo validation of a novel drug eluting coating that has been applied to flexible neural probes. The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biod ...

2007

The effect of biodegradable drug release coatings on the electrical characteristrics of neural electrodes

Philippe Renaud, Arnaud Bertsch, Marc Jasper Boers, Jeffrey Alan Hubbell, André Mercanzini

2007

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

Antigen targeting and adjuvancy schemes that respectively facilitate delivery of antigen to dendritic cells and elicit their activation have been explored in vaccine development. Here we investigate whether nanoparticles can be used as a vaccine platform b ...

Nature Publishing Group2007

Molecular variant fibrinogen fusion proteins

Jeffrey Alan Hubbell, Thomas Barker

Fibrinogen fusion proteins, methods of making, and methods of using fibrinogen fusion proteins are described. In a preferred embodiment the fibrinogen fusion protein contains a truncated Aa chain of fibrinogen. The Aa chain contains truncation site, which ...

2007

Triblock copolymers for cytoplasmic delivery of gene-based drugs

Jeffrey Alan Hubbell

The invention features a triblock copolymer including a hydrophilic block a hydrophobic block and a positively charged block capable of reversibly complexing a negatively charged molecule, e.g., a nucleic acid, wherein the hydrophobic block is disposed bet ...

2007

In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles

Annemie Rehor, Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

Delivery of biodegradable nanoparticles to antigen-presenting cells (APCs), specifically dendritic cells (DCs), has potential for immunotherapy. This study investigates the delivery of 20, 45, and 100nm diameter poly(ethylene glycol)-stabilized poly(propyl ...

2006

Targeting dendritic cells with biomaterials: developing the next generation of vaccines

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

Current vaccine and immunotherapy technology faces ongoing challenges in both efficacy and practicality: many chronic diseases cannot yet be addressed by vaccination, and several vaccines that do function well require multiple injections, which is a substa ...

2006

Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids

Jeffrey Alan Hubbell

The application describes ligands for binding targets, the ligands preferably including peptides having at least one sulfated or sulfonated amino acid. The ligand preferably specifically binds to heparin binding sites of biomolecules. Compositions, systems ...

2006

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