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Pierre Magistretti

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Publications associées (180)

Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice

Sylvain Eric Lengacher, Pierre Magistretti, Luc Pellerin

The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues. Genetically modified C57BL/6J mice were produced by targeted disruption of the mct1 gene in order to understand the ...

Public Library of Science2013

Lactate Modifies Neuronal Excitability Through Both Nmda And Katp Receptors: Importance For Plasticity Genes Expression

Pierre Magistretti, Pascal Jourdain, Igor Allaman, Jean-Marie Petit, Gabriele Grenningloh, Evelyne Ruchti, Jiangyan Yang

Wiley-Blackwell2013

Perturbation Of Sleep-Wake Cycle Affects Astroglial Networking

Pierre Magistretti, Jean-Marie Petit

Wiley-Blackwell2013

Marker-free phase nanoscopy

Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Nicolas Pavillon, Pascal Jourdain, Daniel Boss, Yann Jérôme Michel Pascal Cotte, Muhammed Fatih Toy

We introduce a microscopic method that determines quantitative optical properties beyond the optical diffraction limit and allows direct imaging of unstained living biological specimens. In established holographic microscopy, complex fields are measured us ...

Nature Publishing Group2013

Lactate As A Signaling Molecule For The Regulation Of Plasticity-Related Genes Expression

Pierre Magistretti, Pascal Jourdain, Igor Allaman, Jean-Marie Petit, Gabriele Grenningloh, Evelyne Ruchti, Jiangyan Yang

Wiley-Blackwell2013

The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes

Pierre Magistretti, Jean-Marie Petit, Joël Gyger, Xinhe Liu

Sleep wake cycle is characterized by changes in neuronal network activity. However, for the last decade there is increasing evidence that neuroglial interaction may play a role in the modulation of sleep homeostasis and that astrocytes have a critical impa ...

Elsevier2013

Lactate as a signaling molecule for the regulation of plasticity-related genes expression

Pierre Magistretti, Pascal Jourdain, Igor Allaman, Jean-Marie Petit, Gabriele Grenningloh, Evelyne Ruchti, Jiangyan Yang

Wiley-Blackwell2013

Measurement of absolute cell volume, osmotic membrane water permeability, and refractive index of transmembrane water and solute flux by digital holographic microscopy

Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Pascal Jourdain, Daniel Boss

A dual-wavelength digital holographic microscope to measure absolute volume of living cells is proposed. The optical setup allows us to reconstruct two quantitative phase contrast images at two different wavelengths from a single hologram acquisition. When ...

SPIE Society of Photo-optical Instrumentation Engineers2013

Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS

Patrick Aebischer, Philippe Renaud, Sylvain Eric Lengacher, Pierre Magistretti, Anja Kunze, Elisabeth Anne Dirren

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. ALS is believed to be a non-cell autonomous condition, as other cell types, including astrocytes, have been implicated in disease pathogenesis. Hence, to facilitate the developmen ...

Royal Soc Chemistry2013

Brain Lactate Metabolism in Humans With Subarachnoid Hemorrhage

Pierre Magistretti

2012

Early Cell Death Detection with Digital Holographic Microscopy

Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Nicolas Pavillon, Pascal Jourdain, Corinne Moratal

Background: Digital holography provides a non-invasive measurement of the quantitative phase shifts induced by cells in culture, which can be related to cell volume changes. It has been shown previously that regulation of cell volume, in particular as it r ...

Public Library of Science2012

Regulation of astrocytic connexins following sleep deprivation in mice

Pierre Magistretti, Jean-Marie Petit, Joël Gyger

Wiley-Blackwell2012

New Evidence of Neuroprotection by Lactate after Transient Focal Cerebral Ischaemia: Extended Benefit after Intracerebroventricular Injection and Efficacy of Intravenous Administration

Pierre Magistretti, Ximena Castillo

Background: Lactate protects mice against the ischaemic damage resulting from transient middle cerebral artery occlusion (MCAO) when administered intracerebroventricularly at reperfusion, yielding smaller lesion sizes and a better neurological outcome 48 h ...

Karger2012

Astrocytes display different pattern of gene expression related to neuro-metabolic coupling in anterior and posterior hypothalamus of mice

Pierre Magistretti, Jean-Marie Petit, Joël Gyger, Anna Mikhaleva

Wiley-Blackwell2012

Spatially-Resolved Eigenmode Decomposition of Red Blood Cells Membrane Fluctuations Questions the Role of ATP in Flickering

Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Dimitri Nestor Alice Van De Ville, Annick Hoffmann, Daniel Boss, Benjamin Rappaz

Red blood cells (RBCs) present unique reversible shape deformability, essential for both function and survival, resulting notably in cell membrane fluctuations (CMF). These CMF have been subject of many studies in order to obtain a better understanding of ...

Public Library Science2012

What role in cerebral activity?

Pierre Marquet, Pierre Magistretti, Pascal Jourdain

2012

Emergence of the cerebral self, from Theodor Meynert to Antonio Damasio

Pierre Magistretti, Mathieu Arminjon

Antonio Damasio's works have brought emotions into line with current trends in neuroscience. They are conceived as the addition, to a perception, of the somatic effects it has induced. Nevertheless, this continuous and relatively steady process of body per ...

2011

Association of Candidate Genes with Phenotypic Traits Relevant to Anorexia Nervosa

Pierre Magistretti

This analysis is a follow-up to an earlier investigation of 182 genes selected as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN). As those initial case-control results revealed no statistically significant difference ...

2011

Differential effects of pro- and anti-inflammatory cytokines alone or in combinations on the metabolic profile of astrocytes

Pierre Magistretti, Igor Allaman

We have previously reported that the pro-inflammatory cytokines tumor necrosis factor-α (TNFα) and interleukin-1β (IL-1β) induce profound modifications of the metabolic profile of astrocytes. The present study was undertaken to further characterize the eff ...

Wiley-Blackwell2011

Neuron-glia metabolic coupling and plasticity

Pierre Magistretti

The focus of the current research projects in my laboratory revolves around the question of metabolic plasticity of neuron-glia coupling. Our hypothesis is that behavioural conditions, such as for example learning or the sleep-wake cycle, in which synaptic ...

Wiley-Blackwell2011

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