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Pierre Magistretti

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Publications associées (180)

High throughput second harmonic imaging for label-free biological applications

Pierre Marquet, Pierre Magistretti, Pascal Jourdain, Aleksandra Radenovic, Sylvie Roke, Carlos Alberto Macias Romero, Marie Eve Pascale Didier, Vitalijs Zubkovs, Orly Bagunu Tarun

Second harmonic generation (SHG) is inherently sensitive to the absence of spatial centrosymmetry, which can render it intrinsically sensitive to interfacial processes, chemical changes and electrochemical responses. Here, we seek to improve the imaging th ...

Optical Society of America2014

Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain

Pierre Magistretti, Reto Meuli, Jocelyne Bloch

Experimental evidence suggests that lactate is neuroprotective after acute brain injury; however, data in humans are lacking. We examined whether exogenous lactate supplementation improves cerebral energy metabolism in humans with traumatic brain injury (T ...

Springer Verlag2014

Characterization of genetic variation in the VGLL4 gene in anorexia nervosa

Pierre Magistretti

Lippincott Williams & Wilkins2014

Control of Mitochondrial pH by Uncoupling Protein 4 in Astrocytes Promotes Neuronal Survival

Sylvain Eric Lengacher, Pierre Magistretti, Jean-Yves Chatton, Hélène Danielle Perreten Lambert, Manuel Raphael Zenger

Brain activity is energetically costly and requires a steady and highly regulated flow of energy equivalents between neural cells. It is believed that a substantial share of cerebral glucose, the major source of energy of the brain, will preferentially be ...

American Society for Biochemistry and Molecular Biology2014

Connexin30 knock-out mice display less spontaneous locomotor activity, more sleep pressure and a reduced expression of metabolism-related genes

Pierre Magistretti, Valérie Eligert

Wiley-Blackwell2014

The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy

Pierre Marquet, Sylvain Eric Lengacher, Pierre Magistretti, Pascal Jourdain

The transmembrane water movements during cellular processes and their relationship to ionic channel activity remain largely unknown. As an example, in epithelial cells it was proposed that the movement of water could be directly linked to cystic fibrosis t ...

Company of Biologists2014

Hypertonic lactate and the injured brain: facts and the potential for positive clinical implications

Pierre Magistretti

Springer Verlag2014

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Pierre Magistretti, Pascal Jourdain, Igor Allaman, Jean-Marie Petit, Gabriele Grenningloh, Evelyne Ruchti, Jiangyan Yang

L-lactate is a product of aerobic glycolysis that can be used by neurons as an energy substrate. Here we report that in neurons L-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism invo ...

National Academy of Sciences2014

Circadian Variations Of Gene Expression Related To Neuro-Metabolic Coupling In Astrocytes Of Anterior And Posterior Hypothalamus Of The Mice

Pierre Magistretti, Jean-Marie Petit, Joël Gyger

Wiley-Blackwell2013

Inhibitory Avoidance Learning Is Associated With Altered Expression Of Genes Involved In Neuron-Glia Metabolic Coupling

Sylvain Eric Lengacher, Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Monika Tadi

Wiley-Blackwell2013

Monocarboxylate Transporter 1 (Mct1) Is Critical For Regeneration In Peripheral Nerves

Sylvain Eric Lengacher, Pierre Magistretti, Luc Pellerin

Wiley-Blackwell2013

Genes Involved in the Astrocyte-Neuron Lactate Shuttle (ANLS) Are Specifically Regulated in Cortical Astrocytes Following Sleep Deprivation in Mice

Jean-Luc Martin, Pierre Magistretti, Jean-Marie Petit, Sophie Burlet Godinot, Joël Gyger

Study Objectives: There is growing evidence indicating that in order to meet the neuronal energy demands, astrocytes provide lactate as an energy substrate for neurons through a mechanism called "astrocyte-neuron lactate shuttle" (ANLS). Since neuronal act ...

American Academy of Sleep Medicine2013

Estimation Of Glycolytic Rates Of Single Cells In Vivo

Sylvain Eric Lengacher, Pierre Magistretti

Wiley-Blackwell2013

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

Pierre Magistretti, Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Didier Trono, Anna Claire Groner, Cristina Marquez Vega, Guillaume Poirier

Although adverse early life experiences have been found to increase lifetime risk to develop violent behaviors, the neurobiological mechanisms underlying these long-term effects remain unclear. We present a novel animal model for pathological aggression in ...

Nature Publishing Group2013

Cerebral extracellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury

Pierre Magistretti, Reto Meuli, Jocelyne Bloch

Growing evidence suggests that endogenous lactate is an important substrate for neurons. This study aimed to examine cerebral lactate metabolism and its relationship with brain perfusion in patients with severe traumatic brain injury (TBI). A prospective c ...

Nature Publishing Group2013

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

Jean-Luc Martin, Pierre Magistretti, Igor Allaman

There is growing evidence that astrocytes are involved in the neuropathology of major depression. In particular, decreases in glial cell density observed in the cerebral cortex of individuals with major depressive disorder are accompanied by a reduction of ...

Bentham Science Publishers2013

The Challenge of Connecting the Dots in the BRAIN

Pierre Magistretti, Christian David

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative has focused scientific attention on the necessary tools to understand the human brain and mind. Here, we outline our collective vision for what we can achieve within a dec ...

Elsevier2013

Influence of CRTC1 Polymorphisms on Body Mass Index and Fat Mass in Psychiatric Patients and the General Adult Population

Pierre Magistretti, Jean-René Cardinaux, Murielle Bochud

IMPORTANCE There is a high prevalence of obesity in psychiatric patients, possibly leading to metabolic complications and reducing life expectancy. The CREB-regulated transcription coactivator 1 (CRTC1) gene is involved in energy balance and obesity in ani ...

Amer Medical Assoc2013

Exploring Neural Cell Dynamics with Digital Holographic Microscopy

Christian Depeursinge, Pierre Marquet, Pierre Magistretti

In this review, we summarize how the new concept of digital optics applied to the field of holographic microscopy has allowed the development of a reliable and flexible digital holographic quantitative phase microscopy (DH-QPM) technique at the nanoscale p ...

Annual Reviews2013

Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy

Gerardo Turcatti, Christian Depeursinge, Marc Chambon, Jonas Kühn, Pierre Magistretti, Benjamin Rappaz, Julien Mena, Jérôme Parent, Etienne Shaffer

We introduce a label-free technology based on digital holographic microscopy (DHM) with applicability for screening by imaging, and we demonstrate its capability for cytotoxicity assessment using mammalian living cells. For this first high content screenin ...

Mary Ann Liebert2013

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