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Pierre Magistretti

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Publications associées (180)

Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes

Jean-Luc Martin, Pierre Magistretti, Igor Allaman

RATIONALE: The pharmacological actions of most antidepressants are ascribed to the modulation of serotonergic and/or noradrenergic transmission in the brain. During therapeutic treatment for major depression, fluoxetine, one of the most commonly prescribed ...

Springer Verlag2011

JULIDE: a software tool for 3D reconstruction and statistical analysis of autoradiographic mouse brain sections

Jean-Philippe Thiran, Pierre Magistretti, Rémi Charrier, Delphine Ribes Lemay

In this article we introduce JULIDE, a software toolkit developed to perform the 3D reconstruction, intensity normalization, volume standardization by 3D image registration and voxel-wise statistical analysis of autoradiographs of mouse brain sections. Thi ...

Public Library of Science2011

In Vivo Evidence for Lactate as a Neuronal Energy Source

Pierre Magistretti, Renaud Jolivet

Cerebral energy metabolism is a highly compartmentalized and complex process in which transcellular trafficking of metabolites plays a pivotal role. Over the past decade, a role for lactate in fueling the energetic requirements of neurons has emerged. Furt ...

2011

Altered Glycogen Metabolism in Cultured Astrocytes from Mice with Chronic Glutathione Deficit; Relevance for Neuroenergetics in Schizophrenia

Pierre Magistretti, Igor Allaman, Jean-Marie Petit, Kim Do

Neurodegenerative and psychiatric disorders including Alzheimer's, Parkinson's or Huntington's diseases and schizophrenia have been associated with a deficit in glutathione (GSH). In particular, a polymorphism in the gene of glutamate cysteine ligase modul ...

Public Library of Science2011

Astrocyte-neuron metabolic relationships: for better and for worse

Pierre Magistretti, Igor Allaman

In recent years, previously unsuspected roles of astrocytes have been revealed, largely owing to the development of new tools enabling their selective study in situ. These exciting findings add to the large body of evidence demonstrating that astrocytes pl ...

Elsevier2011

Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

Pierre Magistretti, Igor Allaman, Jean-Marie Petit, Thierry Laroche, Jiangyan Yang

The glyoxalase system is the most important pathway for the detoxification of methylglyoxal (MG), a highly reactive dicarbonyl compound mainly formed as a by-product of glycolysis. MG is a major precursor of advanced glycation end products (AGEs), which ar ...

2011

Genetic Association of Recovery from Eating Disorders: The Role of GABA Receptor SNPs

Pierre Magistretti

Follow-up studies of eating disorders (EDs) suggest outcomes ranging from recovery to chronic illness or death, but predictors of outcome have not been consistently identified. We tested 5151 single-nucleotide polymorphisms (SNPs) in approximately 350 cand ...

2011

Determination of Transmembrane Water Fluxes in Neurons Elicited by Glutamate Ionotropic Receptors and by the Co-transporters KCC2 and NKCC1: A Digital Holographic Microscopy Study

Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Nicolas Pavillon, Pascal Jourdain, Daniel Boss, Benjamin Rappaz, Corinne Moratal

Digital holographic microscopy (DHM) is a noninvasive optical imaging technique that provides quantitative phase images of living cells. In a recent study, we showed that the quantitative monitoring of the phase signal by DHM was a simple label-free method ...

Society for Neuroscience2011

Association Study of 182 Candidate Genes in Anorexia Nervosa

Pierre Magistretti

We performed association studies with 5,151 SNPs that were judged as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN) based on location under reported linkage peaks, previous results in the literature (182 candidate ge ...

2010

Metabolic response of the cerebral cortex following gentle sleep deprivation and modafinil administration

Pierre Magistretti, Jean-Marie Petit, Christophe Kopp

Objectives: The main energy reserve of the brain is glycogen, which is almost exclusively localized in astrocytes. We previously reported that cerebral expression of certain genes related to glycogen metabolism changed following instrumental sleep deprivat ...

2010

Cell Morphology and Intracellular Ionic Homeostasis explored with a Multimodal Approach combining Epifluorescence and Digital Holographic Microscopy

Christian Depeursinge, Pierre Marquet, Jonas Kühn, Pierre Magistretti, Nicolas Pavillon, Pascal Jourdain, Daniel Boss, Corinne Moratal, Aleksandr Benke

The authors have developed a live-cell multimodality microscope combining epifluorescence with digital holographic microscopy; it has been implemented with a decoupling procedure allowing to separately measure from the quantitative phase important cell par ...

2010

Comment on recent modeling studies of astrocyte-neuron metabolic interactions

Pierre Magistretti, Luc Pellerin, Renaud Jolivet, Igor Allaman

Recent years have seen a surge in mathematical modeling of the various aspects of neuron-astrocyte interactions, and the field of brain energy metabolism is no exception in that regard. Despite the advent of biophysical models in the field, the long-lastin ...

Nature Publishing Group2010

Label-free second harmonic phase imaging of biological specimen by digital holographic microscopy

Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Corinne Moratal, Etienne Shaffer

We have previously developed a new way for nonscanning second-harmonic generation (SHG) microscopy [Opt. Lett. 34, 2450 (2009)]. Based on digital holography, this technique captures, in single-shot hologram acquisition, both the amplitude and the phase of ...

Optical Society of America2010

Neuroscience: Low-cost travel in neurons

Pierre Magistretti

2009

Glial Energy Metabolism: Overview

Pierre Magistretti

Astrocytes exhibit several unique metabolic features. They possess a reserve glycolytic capacity that is used to cope with the burden of gultamate recycling. They contain glycogen stores that can be mobilized to face high energy demands following intense n ...

Elsevier2009

Glycogen metabolism as a marker of astrocyte differentiation

Pierre Magistretti, Luc Pellerin, Igor Allaman

Glycogen is a hallmark of mature astrocytes, but its emergence during astrocytic differentiation is unclear. Differentiation of E14 mouse neurospheres into astrocytes was induced with fetal bovine serum (FBS), Leukemia Inhibitory Factor (LIF), or Ciliary N ...

2009

Optical recording of cell electrical activity by Digital Holographic Microscopy

Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Pascal Jourdain, Daniel Boss, Benjamin Rappaz

2009

Cellular Immunity And Pathological Alterations In Ms Grey Matter

Pierre Magistretti, Igor Allaman

2009

The role of astroglia in neuroprotection

Pierre Magistretti

Astrocytes are the main neural cell type responsible for the maintenance of brain homeostasis. They form highly organized anatomical domains that are interconnected into extensive networks. These features, along with the expression of a wide array of recep ...

2009

Mouse fertility is not dependent on the CREB coactivator Crtc1

Pierre Magistretti, Jean-René Cardinaux

2009

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