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Pierre Magistretti

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Publications associées (180)

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Pierre Magistretti, Jean-René Cardinaux

Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better ...

Elsevier2016

Imaging brain aerobic glycolysis as a marker of synaptic plasticity

Pierre Magistretti

National Academy of Sciences2016

Lactate release from astrocytes to neurons contributes to cocaine memory formation

Pierre Magistretti, Benjamin Boutrel, Benjamin Boury-Jamot

The identification of neural substrates underlying the long lasting debilitating impact of drug cues is critical for developing novel therapeutic tools. Metabolic coupling has long been considered a key mechanism through which astrocytes and neurons active ...

Wiley-Blackwell2016

A Motion Capture Study to Measure the Feeling of Synchrony in Romantic Couples and in Professional Musicians

Pierre Magistretti, Delphine Preissmann, Joan Llobera Mahy

The feeling of synchrony is fundamental for most social activities and prosocial behaviors. However, little is known about the behavioral correlates of this feeling and its modulation by intergroup differences. We previously showed that the subjective feel ...

Frontiers Media2016

Comparisons of verbal fluency brain correlates between adults and adolescents suffering from schizophrenia spectrum disorders: A pilot study

Pierre Marquet, Pierre Magistretti

Background and Objectives: Prefrontal cortex (PFC) dysfunctions leading to cognitive deficits refer to a core feature of schizophrenia spectrum disorders (SSD). This exploratory study compares the effect of SSD on two stages of maturation of PFC. Methods: ...

European Journal Of Psychiatry2016

Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues

Pierre Magistretti, Corrado Cali, Madhusudhanan Srinivasan, Daniya Boges

Advances in the application of electron microscopy (EM) to serial imaging are opening doors to new ways of analyzing cellular structure. New and improved algorithms and workflows for manual and semiautomated segmentation allow us to observe the spatial arr ...

Wiley-Blackwell2016

Quantitative phase-digital holographic microscopy: a new imaging modality to identify original cellular biomarkers of diseases

Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Pascal Jourdain, Benjamin Rappaz, Kaspar Rothenfusser

Quantitative phase microscopy (QPM) has recently emerged as a powerful label-free technique in the field of living cell imaging allowing to non-invasively measure with a nanometric axial sensitivity cell structure and dynamics. Since the phase retardation ...

Spie-Int Soc Optical Engineering2016

Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression

Pierre Magistretti, Jean-René Cardinaux

Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood di ...

Nature Publishing Group2016

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

Pierre Marquet, Pierre Magistretti, Pascal Jourdain, Igor Allaman, Kaspar Rothenfusser

Converging experimental data indicate a neuroprotective action of L-Lactate. Using Digital Holographic Microscopy, we observe that transient application of glutamate (100 μM; 2 min) elicits a NMDA-dependent death in 65% of mouse cortical neurons in culture ...

Nature Research2016

Astrocytic beta(2)-adrenergic receptors mediate hippocampal long-term memory consolidation

Sylvain Eric Lengacher, Pierre Magistretti, Virginia Gao

Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic recepto ...

National Academy of Sciences2016

Sodium Signaling and Astrocyte Energy Metabolism

Pierre Magistretti, Jean-Yves Chatton

The Na+ gradient across the plasma membrane is constantly exploited by astrocytes as a secondary energy source to regulate the intracellular and extracellular milieu, and discard waste products. One of the most prominent roles of astrocytes in the brain is ...

Wiley-Blackwell2016

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush

Sylvain Eric Lengacher, Pierre Magistretti, Luc Pellerin, Lin Jin

Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined. In the central nervous system, monocarboxylate transporter ...

Elsevier2015

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Pierre Magistretti, Igor Allaman

The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expre ...

Elsevier2015

Embodied memory: unconscious smiling modulates emotional evaluation of episodic memories

Pierre Magistretti, Delphine Preissmann, Mathieu Arminjon

Since Damasio introduced the somatic markers hypothesis in Damasio (1994), it has spread through the psychological community, where it is now commonly acknowledged that somatic states are a factor in producing the qualitative dimension of our experiences. ...

Frontiers Media2015

Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2

Pierre Magistretti, Jean-René Cardinaux

CREB-binding protein (CBP) and p300 are transcriptional coactivators involved in numerous biological processes that affect cell growth, transformation, differentiation, and development. In this study, we provide evidence of the involvement of homeodomain-i ...

Elsevier2015

Role of glycogen-derived lactate in synaptic plasticity and memory

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh

Wiley-Blackwell2015

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

Patrick Aebischer, Sylvain Eric Lengacher, Pierre Magistretti, Bernard Schneider

Excitatory synaptic transmission is accompanied by a local surge in interstitial lactate that occurs despite adequate oxygen availability, a puzzling phenomenon termed aerobic glycolysis. In addition to its role as an energy substrate, recent studies have ...

Society for Neuroscience2015

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Pierre Magistretti

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The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Imaging brain aerobic glycolysis as a marker of synaptic plasticity

Lactate release from astrocytes to neurons contributes to cocaine memory formation

A Motion Capture Study to Measure the Feeling of Synchrony in Romantic Couples and in Professional Musicians

Comparisons of verbal fluency brain correlates between adults and adolescents suffering from schizophrenia spectrum disorders: A pilot study

Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues

Quantitative phase-digital holographic microscopy: a new imaging modality to identify original cellular biomarkers of diseases

Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

Astrocytic beta(2)-adrenergic receptors mediate hippocampal long-term memory consolidation

Sodium Signaling and Astrocyte Energy Metabolism

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Embodied memory: unconscious smiling modulates emotional evaluation of episodic memories

Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2

Role of glycogen-derived lactate in synaptic plasticity and memory

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

Modulation of astrocytic glucose metabolism by the antidiabetic drug metformin

Astrocytes may be behind the pathogenesis of 22q11

Astrocyte swelling in response to neural activation: role of cotransporters