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Giovanni Dietler

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Publications associées (156)

Nuclear Factor I genomic binding associates with chromatin boundaries

Nicolas Mermod, Philipp Bucher, Giovanni Dietler, Jan Kerschgens, Armelle Gaussin, Giovanna Ambrosini, Petar Pjanic

Background: The Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation. Using chromatin immuno-precipitation and high throughput sequenci ...

BioMed Central2013

A universal fluid cell for the imaging of biological specimens in the atomic force microscope

Charles Roduit, Giovanni Dietler, Sandor Kasas, Livan Bladimir Alonso Sarduy, Giovanni Longo, Bhaskar Saha

Recently, atomic force microscope (AFM) manufacturers have begun producing instruments specifically designed to image biological specimens. In most instances, they are integrated with an inverted optical microscope, which permits concurrent optical and AFM ...

Wiley-Blackwell2013

Fine DNA structure revealed by constant height frequency modulation AFM imaging

Giovanni Dietler, Dusan Vobornik, Andrea Cerreta

Few examples of sub nanometer resolution on biomolecules can be found in literature. In particular, AFM experiments on DNA mostly fail to show the double helical groove periodicity, and so far such a feat was only achieved in liquid. Here we describe a met ...

Elsevier2013

Photonic Crystal Biosensor Based on Optical Surface Waves

Giovanni Dietler, Serguei Sekatski, Tatyana Karakouz, Chiara Vicario

A label-free biosensor device based on registration of photonic crystal surface waves is described. Angular interrogation of the optical surface wave resonance is used to detect changes in the thickness of an adsorbed layer, while an additional simultaneou ...

Mdpi Ag2013

Dependence of the most probable and average bond rupture force on the force loading rate: First order correction to the Bell-Evans model

Giovanni Dietler, Serguei Sekatski, Fabrizio Benedetti

The Bell-Evans model which predicts the linear dependence of the most probable intermolecular bond rupture force on the logarithm of stretching force loading rate is usually used to discuss the dynamic force spectroscopy experiment data. This model is cons ...

American Institute of Physics2013

Dependence of the Most Probable and Average Bond Rupture Forces on the Force Loading Rate in Single Molecule Dynamic Force Spectroscopy Experiment: First Order Correction to the Bell-Evans Model

Giovanni Dietler, Serguei Sekatski, Fabrizio Benedetti

Cell Press2013

Blue surface plasmon propagation along thin gold film-gas interface and its use for sensitive nitrogen dioxide detection

Giovanni Dietler, Serguei Sekatski

We demonstrate effective surface plasmon propagation along thin gold film in a blue spectral range: the measured 0.6 degrees angular width of the plasmon excitation peak corresponds to the propagation length around 7 mu m. For this end, we prepared a speci ...

Elsevier2013

Rapid detection of bacterial resistance to antibiotics using AFM cantilevers as nanomechanical sensors

Giovanni Dietler, Sandor Kasas, Justin Terence Notz Pekkanen, Livan Bladimir Alonso Sarduy, Giovanni Longo, Laura Rio Marques

The widespread misuse of drugs has increased the number of multiresistant bacteria1, and this means that tools that can rapidly detect and characterize bacterial response to antibiotics are much needed in the management of infections. Various techniques, s ...

Nature Publishing Group2013

Luminescence studies on photostimulable phosphor CsBr:Eu2+

Giovanni Dietler, Serguei Sekatski, Kanat Dukenbayev

Photostimulable phosphor CsBr:Eu2+ is prepared through a solid-state reaction. The effect of annealing atmosphere on photoluminescence and photostimulated luminescence was investigated. Optimum luminescence intensity was obtained when samples were prepared ...

Taylor & Francis2013

A single-molecule stretching method for lateral and normal AFM lever calibration

Andrzej Kulik, Giovanni Dietler, Fabrizio Benedetti

A novel method for quantitative lateral force measurement (LFM) calibration has been developed. Using a single-molecule spectroscopy approach it is possible to calibrate the AFM levers for both lateral and normal spring constants with a single image scan. ...

Institute of Physics2013

Nanoscale motion detector

Giovanni Dietler, Sandor Kasas, Livan Bladimir Alonso Sarduy, Giovanni Longo

Motion detector comprising a flexible support (1,5) adapted to hold at least one object (6-9), a sensor (4) for measuring the displacement of said support (1) and processing means for differentiating the fluctuations of said support (1) from those induced ...

2013

Sedimentation of macroscopic rigid knots and its relation to gel electrophoretic mobility of DNA knots

Cédric Weber, Giovanni Dietler, Andrzej Stasiak, Mathias Carlen

We address the general question of the extent to which the hydrodynamic behaviour of microscopic freely fluctuating objects can be reproduced by macrosopic rigid objects. In particular, we compare the sedimentation speeds of knotted DNA molecules undergoin ...

Nature Publishing Group2013

Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin

Giovanni Dietler, Sandor Kasas, Livan Bladimir Alonso Sarduy, Giovanni Longo

Cancer is a major health issue that absorbs the attention of a large part of the biomedical research. Intercalating agents bind to DNA molecules and can inhibit their synthesis and transcription; thus, they are increasingly used as drugs to fight cancer. I ...

American Chemical Society2013

Combination of fluorescence microscopy and nanomotion detection to characterize bacteria

Giovanni Dietler, Sandor Kasas, Justin Terence Notz Pekkanen, Giovanni Longo

Antibiotic-resistant pathogens are a major health concern in everyday clinical practice. Because their detection by conventional microbial techniques requires minimally 24h, some of us have recently introduced a nanomechanical sensor, which can reveal moti ...

Wiley-Blackwell2013

Stiffness tomography exploration of living and fixed macrophages

Charles Roduit, Giovanni Dietler, Sandor Kasas, Andrea Volterra, Giovanni Longo, Bhaskar Saha

Stiffness tomography is a new atomic force microscopy imaging technique that allows highlighting structures located underneath the surface of the sample. In this imaging mode, such structures are identified by investigating their mechanical properties. We ...

Wiley-Blackwell2012

Quantifying supercoiling-induced denaturation bubbles in DNA

Giovanni Dietler

In both eukaryotic and prokaryotic DNA sequences of 30-100 base-pairs rich in AT base-pairs have been identified at which the double helix preferentially unwinds. Such DNA unwinding elements are commonly associated with origins for DNA replication and tran ...

Royal Society of Chemistry2012

Controlling a Single DNA Molecule in an Electric Field by Means of In Situ Atomic Force Microscopy

Giovanni Dietler, Jae Sun Jeong

DNA is the bio-polymer containing the genetic information needed for the development and functioning for all living organisms. It has a polymeric structure consisting of units called nucleotides, each consisting of a non-polar, hydrophobic interior (the ba ...

Electrochemical Society2012

Force volume and stiffness tomography investigation on the dynamics of stiff material under bacterial membranes

Charles Roduit, Giovanni Dietler, Sandor Kasas, Giovanni Longo, Laura Rio Marques

The determination of the characteristics of micro-organisms in clinical specimens is essential for the rapid diagnosis and treatment of infections. A thorough investigation of the nanoscale properties of bacteria can prove to be a fundamental tool. Indeed, ...

Wiley-Blackwell2012

Atomic Force Microscopy Stiffness Tomography on Living Arabidopsis thaliana Cells Reveals the Mechanical Properties of Surface and Deep Cell-Wall Layers during Growth

Charles Roduit, Giovanni Dietler, Sandor Kasas, Christian Fankhauser

Cell-wall mechanical properties play a key role in the growth and the protection of plants. However, little is known about genuine wall mechanical properties and their growth-related dynamics at subcellular resolution and in living cells. Here, we used ato ...

Elsevier2012

Differential peptide binding to CD40 evokes counteractive responses

Charles Roduit, Giovanni Dietler, Sandor Kasas, Livan Bladimir Alonso Sarduy, Bhaskar Saha

The antigen-presenting cell-expressed CD40 is implied in the regulation of counteractive immune responses such as induction of pro-inflammatory and anti-inflammatory cytokines interleukin (IL)-12 and IL-10, respectively. The mechanism of this duality in CD ...

Elsevier2012

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