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Meritxell Bach Cuadra

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Publications associées (113)

Evolution of Cortical and White Matter Lesion Load in Early-Stage Multiple Sclerosis: Correlation With Neuroaxonal Damage and Clinical Changes

Meritxell Bach Cuadra, Guillaume Bonnier, Cristina Granziera, Mario Joao Fartaria de Oliveira, Po-Jui Lu

Introduction:Changes in cortical and white matter lesion (CL, WML) load are pivotal metrics to diagnose and monitor multiple sclerosis patients. Yet, the relationship between (i) changes in CL/WML load and disease progression and between (ii) changes in CL ...

FRONTIERS MEDIA SA2020

Multiple sclerosis cortical and WM lesion segmentation at 3T MRI: a deep learning method based on FLAIR and MP2RAGE

Jean-Philippe Thiran, Meritxell Bach Cuadra, Ahmed Abdulkadir, Cristina Granziera, Mario Joao Fartaria de Oliveira, Po-Jui Lu, Muhamed Barakovic, Francesco La Rosa

The presence of cortical lesions in multiple sclerosis patients has emerged as an important biomarker of the disease. They appear in the earliest stages of the illness and have been shown to correlate with the severity of clinical symptoms. However, cortic ...

2020

Normalization of aberrant pretherapeutic dynamic functional connectivity of extrastriate visual system in patients who underwent thalamotomy with stereotactic radiosurgery for essential tremor: a resting-state functional MRI study

Jean-Philippe Thiran, Meritxell Bach Cuadra, Dimitri Nestor Alice Van De Ville, Elena Najdenovska, Thomas William Arthur Bolton, Constantin Tuleasca

OBJECTIVE The tremor circuitry has commonly been hypothesized to be driven by one or multiple pacemakers within the cerebello-thalamo-cortical pathway, including the cerebellum, contralateral motor thalamus, and primary motor cortex. However, previous stud ...

2020

Partial-volume modeling reveals reduced gray matter in specific thalamic nuclei early in the time course of psychosis and chronic schizophrenia

Meritxell Bach Cuadra, Patric Hagmann, Elena Najdenovska, Zita Rovó, Mario Joao Fartaria de Oliveira, Erick Jorge Canales Rodriguez, Kim Do

The structural complexity of the thalamus, due to its mixed composition of gray and white matter, make it challenging to disjoint and quantify each tissue contribution to the thalamic anatomy. This work promotes the use of partial-volume-based over probabi ...

Wiley2020

Quantification in Musculoskeletal Imaging Using Computational Analysis and Machine Learning: Segmentation and Radiomics

Meritxell Bach Cuadra

Although still limited in clinical practice, quantitative analysis is expected to increase the value of musculoskeletal (MSK) imaging. Segmentation aims at isolating the tissues and/or regions of interest in the image and is crucial to the extraction of qu ...

THIEME MEDICAL PUBL INC2020

CVSnet: A machine learning approach for automated central vein sign assessment in multiple sclerosis

Jonas Richiardi, Meritxell Bach Cuadra, Reto Meuli, Tobias Kober, Cristina Granziera, João Pedro Forjaco Jorge, Mario Joao Fartaria de Oliveira, Francesco La Rosa

The central vein sign (CVS) is an efficient imaging biomarker for multiple sclerosis (MS) diagnosis, but its application in clinical routine is limited by inter-rater variability and the expenditure of time associated with manual assessment. We describe a ...

2020

Model-informed machine learning for multi-component T2 relaxometry

Jean-Philippe Thiran, Meritxell Bach Cuadra, Tobias Kober, Elda Fischi Gomez, Cristina Granziera, Tom Hilbert, Muhamed Barakovic, Gian Franco Piredda, Erick Jorge Canales Rodriguez, Marco Pizzolato, Thomas Yu

Recovering the distribution from multi-echo magnetic resonance (MR) signals is challenging but has high potential as it provides biomarkers characterizing the tissue micro-structure, such as the myelin water fraction (MWF). In this work, we propose to comb ...

2020

RimNet: A deep 3D multimodal MRI architecture for paramagnetic rim lesion assessment in multiple sclerosis

Meritxell Bach Cuadra, Tobias Kober, Hamza Kebiri, Cristina Granziera, Po-Jui Lu, Francesco La Rosa

Objectives In multiple sclerosis (MS), the presence of a paramagnetic rim at the edge of non-gadolinium-enhancing lesions indicates perilesional chronic inflammation. Patients featuring a higher paramagnetic rim lesion burden tend to have more aggressive d ...

2020

Automated Detection and Segmentation of Multiple Sclerosis Lesions Using Ultra-High-Field MP2RAGE

Meritxell Bach Cuadra, Tobias Kober, Cristina Granziera, Kieran O'Brien, Mario Joao Fartaria de Oliveira

Objectives The aim of this study was to develop a new automated segmentation method of white matter (WM) and cortical multiple sclerosis (MS) lesions visible on magnetization-prepared 2 inversion-contrast rapid gradient echo (MP2RAGE) images acquired at 7 ...

LIPPINCOTT WILLIAMS & WILKINS2019

A Novel Spatial-Angular Domain Regularisation Approach for Restoration of Diffusion MRI

Jean-Philippe Thiran, Meritxell Bach Cuadra, Alessandro Daducci, Alessandro Mella

In this paper we tackle the problem of regularisation for inverse problems in single shell diffusion weighted image restoration. Our aim is to recover a high-resolution and denoised DWI signal, prior to any model fitting. The main contribution of our metho ...

SPRINGER-VERLAG BERLIN2019

Comparison of MRI-based automated segmentation methods and functional neurosurgery targeting with direct visualization of the Ventro-intermediate thalamic nucleus at 7T

Jean-Philippe Thiran, Meritxell Bach Cuadra, Elena Najdenovska, José Pedro Rebelo Ferreira Marques, João Pedro Forjaco Jorge, Daniel Gallichan, Constantin Tuleasca

The ventro-intermediate nucleus (Vim), as part of the motor thalamic nuclei, is a commonly used target in functional stereotactic neurosurgery for treatment of drug-resistant tremor. As it cannot be directly visualized on routinely used magnetic resonance ...

Nature Research2019

Letter: Deep Brain Stimulation of the Pedunculopontine Nucleus Area in Parkinson Disease: Magnetic Resonance Imaging- Based Anatomoclinical Correlations and Optimal Target

Jean-Philippe Thiran, Meritxell Bach Cuadra, Dimitri Nestor Alice Van De Ville, Elena Najdenovska, Constantin Tuleasca, Adrien Jean Régis Maurice Hilaire

OXFORD UNIV PRESS INC2019

Resting-state functional MRI for functional neurosurgery: seeing the light?

Jean-Philippe Thiran, Meritxell Bach Cuadra, Dimitri Nestor Alice Van De Ville, Elena Najdenovska, Constantin Tuleasca

AMER ASSOC NEUROLOGICAL SURGEONS2019

Axonal and myelin injury in white matter and cortex of relapsing-remitting and progressive multiple sclerosis patients: a combined myelin water and multi-shell diffusion MRI study

Meritxell Bach Cuadra, Cristina Granziera, Po-Jui Lu, Francesco La Rosa, Yi Wang

SAGE PUBLICATIONS LTD2019

Deep learning analysis applied to multi-parametric advanced MRI shows higher myelin content and neurite density in juxtacortical lesions compared to periventricular lesions

Meritxell Bach Cuadra, Cristina Granziera, Alessandro Daducci, Po-Jui Lu, Francesco La Rosa, Yi Wang

SAGE PUBLICATIONS LTD2019

Longitudinal analysis of white matter and cortical lesions in multiple sclerosis

Meritxell Bach Cuadra, Tobias Kober, Cristina Granziera, Mario Joao Fartaria de Oliveira

Purpose: The goals of this study were to assess the performance of a novel lesion segmentation tool for longitudinal analyses, as well as to validate the generated lesion progression map between two time points using conventional and non-conventional MR se ...

2019

Episodic memory decline in Parkinson' s disease: relation with white matter hyperintense lesions and influence of quantification method

Meritxell Bach Cuadra, Bénédicte Marie Maréchal, Tobias Kober, Mario Joao Fartaria de Oliveira

The relation of white matter hyperintense lesions to episodic memory impairment in patients with Parkinson's disease (PD) is still controversial. We aimed at evaluating the relation between white matter hyperintense lesions and episodic memory decline in p ...

SPRINGER2019

Deep learning-based detection of cortical lesions in multiple sclerosis patients with FLAIR, DIR, and MP2RAGE MRI sequences

Jean-Philippe Thiran, Meritxell Bach Cuadra, Cristina Granziera, Mario Joao Fartaria de Oliveira, Po-Jui Lu, Francesco La Rosa

London, SAGE PUBLICATIONS LTD2019

A fully automated approach for differential diagnosis support in multiple sclerosis based on the central vein sign

Meritxell Bach Cuadra, Reto Meuli, Tobias Kober, Cristina Granziera, Mario Joao Fartaria de Oliveira

SAGE PUBLICATIONS LTD2019

Deep learning-based detection of cortical lesions in multiple sclerosis patients with FLAIR, DIR, and MP2RAGE MRI sequences

Jean-Philippe Thiran, Meritxell Bach Cuadra, Ahmed Abdulkadir, Cristina Granziera, Mario Joao Fartaria de Oliveira, Po-Jui Lu, Francesco La Rosa

SAGE PUBLICATIONS LTD2019

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