As the need for targeting luminescent biolabels increases, for mapping selected analytes, imaging of cells and organs, and tracking in cellulo processes, lanthanide bimetallic helicates are emerging as versatile bioprobes. The wrapping of three ligand stra ...

2008

A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin, Bo Song

The homoditopic ligand 6,6’- [methylenebis(1-methyl-1H-benzimid- azole-5,2-diyl)]bis(4-{2-[2-(2-methoxy- ethoxy)ethoxy]ethoxy}pyridine-2-carboxylic acid) (H2LC2) has been tailored to self-assemble with lanthanide ions (LnIII), which results in the formatio ...

2008

Luminescent coordination nanoparticles

Jean-Claude Bünzli

Water-soluble lanthanide-containing coordination nanoparticles with a size around 4-5 nm were prepared by the growth confinement of the Tb-2(bdc)(3)(H2O)(4) three-dimensional network using an organic polymer; the terbium- and the europium-based objects pre ...

2008

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Bo Song

The cellular uptake mechanism and intracellular distribution of emissive lanthanide helicates have been elucidated by time-resolved luminescence microscopy (TRLM). The helicates are non-cytotoxic and taken up by normal (HaCat) and cancer (HeLa, MCF-7) cell ...

2008

Remarkable Tuning of the Photophysical Properties of Bifunctional Lanthanide tris(Dipicolinates) and its Consequence on the Design of Bioprobes

Jean-Claude Bünzli, Anne-Sophie Chauvin, Anne-Laure Gassner, Céline Rita Duhot

Derivatives of dipicolinic acid with a polyoxyethylene pendant arm at the pyridine 4-position have been functionalized for potential grafting with biological material. Four ligands with different terminal functions (alcohol, methoxy, phtalimide and amine) ...

2008

Visible-Light Excitation of Infrared Lanthanide Luminescence via Intra-Ligand Charge-Transfer State in 1,3-Diketonates Containing Push-Pull Chromophores

Jean-Claude Bünzli, Rosario Scopelliti, Frédéric Gumy

A new 1,3-diketonato ligand containing both an electron-donor [4-(dimethylamino)benzene] and an electron-acceptor (4- nitrobenzene) group and its lanthanide complexes have been prepared. They display an intense intra-ligand charge-transfer absorption trans ...

2008

Enhancement of near-IR emission by bromine substitution in lanthanide complexes with 2-carboxamide-8-hydroxyquinoline

Jean-Claude Bünzli, Frédéric Gumy

Three novel 2-carboxamide-8-hydroxyquinoline derivatives wrap helically around trivalent lanthanide ions to form monometallic 3 : 1 complexes possessing strong NIR emission. ...

Royal Society of Chemistry2007

Lanthanide Complexes with a Calix[8]arene Bearing Phosphinoyl Pendant Arms

Jean-Claude Bünzli, Anne-Sophie Chauvin

The phosphinoyl-substituted macrocyclic receptor B8bL8, derived from p-tert-butylcalix[8]arene, was synthesized and its structure was studied in solution. According to temperaturedependent 1H and 31P NMR spectroscopic data, the calix[8]arene adopts a so-ca ...

2007

Toward the Rational Design of Lanthanide Coordination Polymers: a New Topological Approach

Jean-Claude Bünzli, Marinella Mazzanti

The implementation of four bidentate building blocks into a highdenticity linker with a flexible spacer leads to a predisposed ligand that allows one to direct the self- assembly of 1D functional coordination polymers. This is illustrated by the assembly u ...

2007

Selective Self-Assembly of Hexameric Homo- and Heteropolymetallic Lanthanide Wheels: Synthesis, Structure, and Photophysical Studies

Jean-Claude Bünzli, Marinella Mazzanti

A rational approach to the formation of pure heteropolymetallic lanthanide complexes that uses a two-step assembly strategy and exploits the different size requirements of the two metals included in the final structure is described. The investigation of th ...

2007

Exploring the potential of europium(III) luminescence for the detection of phase transitions in ionic liquid crystals

Jean-Claude Bünzli, Joël Kocher, Frédéric Gumy, Anne-Sophie Chauvin

The ionic liquid crystal [C12-mim]Cl has been doped with 5 mol% europium nitrate and the photophysical properties of both the ionic liquid and the trivalent europium ion have been monitored with respect to temperature in the range of 248 to +120 uC. The re ...

Royal Society of Chemistry2007

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin, Bo Song

The homoditopic ligand

H_2L^{C3}

has been designed to form neutral triple-stranded bimetallic helicates of overall composition [

Ln_2(L^{C3})_3

]. The grafting of the polyoxyethylene fragments ensures water solubility and also favors cell penetration whi ...

2007

Thermodynamic Parameters Governing the Self-Assembly of Head–Head–Head Lanthanide Bimetallic Helicates

Jean-Claude Bünzli, Rosario Scopelliti, Thomas Binderup Jensen

The heterobitopic ligands LABX (X=1,2, 3,4 or 5),diff ering only by a Cl or NEt2 substituent,have been designed to complex with a pair of lanthanide ions to form triple-stranded bimetallic helicates of overall composition [Ln2ACHTUNGTRENUNG(LABX)3]6+. The ...

2007

New Opportunities for Lanthanide Luminescence

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin

Trivalent lanthanide ions display fascinating optical properties. The discovery of the corresponding elements and their fist industrial uses were intimately linked to their optical properties. This relationship has been kept alive until today when many hig ...

2007

Highly Efficient Near-IR Emitting Yb/Yb and Yb/Al Helicates

Jean-Claude Bünzli, Frédéric Gumy, Annina Aebischer

2007

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments

Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin

A new macrocyclic ligand,

L^3

, has been synthesised, based on the cyclen framework grafted with three phenacyl light-harvesting groups and a C5-alkyl chain bearing a carboxylic acid function as a potential linker for biological material. Acidity constant ...

2007

Rational Tuning of Melting Entropies for Designing Luminescent Lanthanide-Containing Thermotropic Liquid Crystals at Room Temperature

Jean-Claude Bünzli, Frédéric Gumy, Annina Aebischer

The connection of twelve peripheral and divergent dodecyloxy chains to a central tridentate aromatic binding unit provides the dodecacatenar ligand L11, for which room- temperature mesomorphism is detected. An enthalpically unbalanced large melting entropy ...

2007

Luminescent lanthanide bimetallic triple-stranded helicates as potential cellular imaging probes

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby, Anne-Sophie Chauvin

Water-soluble triple-stranded [Ln2(L)3] helicates have been successfully tested as imaging probes in human cervical adenocarcinoma cells (HeLa), the complex being not toxic and clearly staining their cytoplasm in a concentrationdependent manner. ...

Royal Society of Chemistry2007

A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range

Jean-Claude Bünzli, Caroline Vandevyver, Steve Comby

A new polydentate tripodal ligand T2soxMe was synthesized to take advantage of the chelating effect of tridentate 8- hydroxyquinolinate subunits. Potentiometric and spectrophotometric titrations reveal seven pKa values of between 3.7 and 10.2. In water, th ...

2007

Page 5 sur 6