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Geoffrey Bodenhausen

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Publications associées (143)

Fast Proton Exchange in Histidine: Measurement of Rate Constants through Indirect Detection by NMR Spectroscopy

Geoffrey Bodenhausen

Owing to its imidazole side chain, histidine participates in various processes such as enzyme catalysis, pH regulation, metal binding, and phosphorylation. The determination of exchange rates of labile protons for such a system is important for understandi ...

Wiley-Blackwell2014

Solid-state NMR measurements and DFT calculations of the magnetic shielding tensors of protons of water trapped in barium chlorate monohydrate

Geoffrey Bodenhausen, Diego Carnevale

The magnetic shielding tensors of protons of water in barium chlorate monohydrate are investigated at room temperature by means of solid-state NMR spectroscopy, both for static powders and under magic-angle spinning conditions, using one- and two-dimension ...

RSC Publishing2014

Exploring Weak Ligand-Protein Interactions by Long-Lived NMR States: Improved Contrast in Fragment-Based Drug Screening

Geoffrey Bodenhausen, Roberto Buratto, Daniele Mammoli

Ligands that have an affinity for protein targets can be screened very effectively by exploiting favorable properties of long-lived states (LLS) in NMR spectroscopy. In this work, we describe the use of LLS for competitive binding experiments to measure ac ...

Wiley-Blackwell2014

Long-Lived States of Magnetically Equivalent Spins Populated by Dissolution-DNP and Revealed by Enzymatic Reactions

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Daniele Mammoli, Xiao Ji

Hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) offers a way of enhancing NMR signals by up to five orders of magnitude in metabolites and other small molecules. Nevertheless, the lifetime of hyperpolarization is inexorably limited, a ...

Wiley-Blackwell2014

Sensitivity improvement during heteronuclear spin decoupling in solid-state nuclear magnetic resonance experiments at high spinning frequencies and moderate radio-frequency amplitudes

Geoffrey Bodenhausen

Searching for optimal conditions during one- and multi-dimensional solid-state NMR experiments in high static fields may require spinning the sample at frequencies above 40 kHz. This implies challenging requirements for heteronuclear spin decoupling. We ha ...

Elsevier2014

Hybrid polarizing solids for pure hyperpolarized liquids through dissolution dynamic nuclear polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, David Benjamin Roger Antoine Gajan, David Lyndon Emsley

Hyperpolarization of substrates for magnetic resonance spectroscopy (MRS) and imaging (MRI) by dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of polarizing agents (PAs; e.g., persistent radicals embedded in ...

National Academy of Sciences2014

Solid-state carbon-13 NMR and computational characterization of the N719 ruthenium sensitizer adsorbed on TiO2 nanoparticles

Michael Graetzel, Geoffrey Bodenhausen, Nicola Salvi, Julien Edouard Frey, Diego Carnevale

The ruthenium-containing sensitizing dye N719 grafted on TiO2 nanoparticles was investigated by solidstate NMR. The carbon resonances are assigned by means of 13C cross-polarized dipolar dephasing experiments. DFT calculations of the carbon magnetic shield ...

Royal Society of Chemistry2014

Microwave frequency modulation to enhance Dissolution Dynamic Nuclear Polarization Dedicated to To Martial Rey, as a token of appreciation

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Angel Joaquin Perez Linde

Hyperpolarization by Dissolution Dynamic Nuclear Polarization is usually achieved by monochromatic microwave irradiation of the ESR spectrum of free radicals embedded in glasses at 1.2 K and 3.35 T. Hovav et al. (2014) have recently shown that by using fre ...

Elsevier2014

Method for nuclear magnetic resonance (NMR) spectroscopy measurements using long-lived coherences (LLC)

Geoffrey Bodenhausen, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja

A method for nuclear magnetic resonance (NMR) spectroscopy of a sample comprises preparation of the sample and carrying out an NMR spectroscopy measurement. Preparation includes excitation of long lived coherences (LLC) between the singlet state S0 and the ...

2013

Solid-state NMR enhanced by dynamic nuclear polarization as a novel tool for ribosome structural biology

Geoffrey Bodenhausen, Marc Anthony Caporini, Diego Carnevale

The impact of Nuclear Magnetic Resonance (NMR) on studies of large macromolecular complexes hinges on improvements in sensitivity and resolution. Dynamic nuclear polarization (DNP) in the solid state can offer improved sensitivity, provided sample preparat ...

Springer Verlag2013

On toxic effects of scientific journals

Geoffrey Bodenhausen

The advent of online publishing greatly facilitates the dissemination of scientific results. This revolution might have led to the untimely death of many traditional publishing companies, since today's scientists are perfectly capable of writing, formattin ...

Indian Academy of Science2013

Boosting Dissolution Dynamic Nuclear Polarization by Cross Polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Angel Joaquin Perez Linde

The efficiency of dissolution dynamic nuclear polarization can be boosted by Hartmann-Hahn cross polarization at temperatures near 1.2 K. This enables high throughput of hyperpolarized solutions with substantial gains in buildup times and polarization leve ...

Amer Chemical Soc2013

Fourier tickling for homonuclear decoupling in nmr

Geoffrey Bodenhausen, Diego Carnevale

PROBLEM TO BE SOLVED: To provide an effective and speedy method for decoupling of homonuclear couplings.SOLUTION: This invention concerns a method for high resolution NMR (nuclear magnetic resonance) measurements comprising the application of excitation pu ...

2013

How to Tickle Spins with a Fourier Transform NMR Spectrometer

Geoffrey Bodenhausen, Diego Carnevale

In the long bygone days of continuous-wave nuclear magnetic resonance (NMR) spectroscopy, a selected transition within a multiplet of a high-resolution spectrum could be irradiated by a highly selective continuous-wave (CW) radio-frequency (rf) field with ...

Wiley-Blackwell2013

Method for the nmr based determination of the affinity of drugs for a target protein

Geoffrey Bodenhausen, Aurélien Bornet, Nicola Salvi, Roberto Buratto

The document relates to a method for the determination of the binding properties of at least one first chemical compound to at least one second chemical compound between a free essentially dissociated state and a bound essentially associated state by using ...

2013

Methods for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements using long-lived states

Arnaud Comment, Geoffrey Bodenhausen, Sami Jannin, Riddhiman Sarkar, Paul Romeo Vasos

A method for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements, includes creation of enhanced polarization of nuclei of a first kind within a sample in a magnetic field at cryogenic temperatures and transfer of the polarized ...

2013

Broadband excitation in solid-state NMR using interleaved DANTE pulse trains with N pulses per rotor period

Geoffrey Bodenhausen, Simone Ulzega, Diego Carnevale

We analyze the direct excitation of wide one-dimensional spectra of nuclei with spin I = 1/2 or 1 in rotating solids submitted to pulse trains in the manner of Delays Alternating with Nutations for Tailored Excitation (DANTE), either with one short rotor-s ...

Academic Press Inc - Elsevier Science2013

Analysis of sensitivity enhancement by dynamic nuclear polarization in solid-state NMR: a case study of functionalized mesoporous materials

Geoffrey Bodenhausen, Diego Carnevale

We systematically studied the enhancement factor (per scan) and the sensitivity enhancement (per unit time) in C-13 and Si-29 cross-polarization magic angle spinning (CP-MAS) NMR boosted by dynamic nuclear polarization (DNP) of functionalized mesoporous si ...

Royal Society of Chemistry2013

Method and device for rapid dnp

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

A method for producing hyperpolarized sample material for use in magnetic resonance investigations, with a) preparing a target material, containing high gamma nuclei with a short T1, - a polarizing agent with a broad EPR line, and low gamma nuclei with a l ...

2013

Modulations of Spin Echoes in Liquids

Geoffrey Bodenhausen

Echo modulations that arise in Carr–Purcell–Meiboom–Gill (CPMG) spin echo sequences and stem from homonuclear couplings can be suppressed by different methods. The evolution under homonuclear couplings can be either ‘‘locked’’ or ‘‘refocused’’, leading to ...

2013

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