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Geoffrey Bodenhausen

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Publications associées (143)

Cross-correlated relaxation measurements under adiabatic sweeps: determination of local order in proteins

Geoffrey Bodenhausen, Fabien Ferrage, Nicola Salvi, Pavel Kaderavek

Adiabatically swept pulses were originally designed for the purpose of broadband spin inversion. Later, unexpected advantages of their utilization were also found in other applications, such as refocusing to excite spin echoes, studies of chemical exchange ...

Springer Verlag2015

Hyperpolarized Water to Study Protein-Ligand Interactions

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Quentin Chappuis

The affinity between a chosen target protein and small molecules is a key aspect of drug discovery. Screening by popular NMR methods such as Water-LOGSY suffers from low sensitivity and from false positives caused by aggregated or denatured proteins. This ...

2015

Spin Noise Detection of Nuclear Hyperpolarization at 1.2K

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

We report proton spin noise spectra of a hyperpolarized solid sample of commonly used DNP (dynamic nuclear polarization) juice containing TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine N-oxide) and irradiated by a microwave field at a temperature of 1.2K ...

Wiley-Blackwell2015

A magnetic tunnel to shelter hyperpolarized fluids

Roger Mottier, Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Pascal Miéville, Basile Vuichoud

To shield solutions carrying hyperpolarized nuclear magnetization from rapid relaxation during transfer through low fields, the transfer duct can be threaded through an array of permanent magnets. The advantages are illustrated for solutions containing hyp ...

American Institute of Physics2015

A bright future for magnetic resonance

Geoffrey Bodenhausen

This contribution seeks to identify a few factors that have contributed to the success of a thriving discipline, and to identify threats that could put future prospects at risk. Many of these factors are not specific to magnetic resonance, and may also app ...

Springer2015

Hyperpolarized para-Ethanol

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Daniele Mammoli

We show that an imbalance between the populations of singlet (S) and triplet (T) states in pairs of magnetically equivalent spins can be generated by dissolution dynamic nudear polarization: In partly deuterated ethanol ((CD3CH2OD)-C-13), this T/S imbalanc ...

Amer Chemical Soc2015

Challenges in preparing, preserving and detecting para-water in bulk: overcoming proton exchange and other hurdles

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Nicola Salvi, Diego Carnevale, Roberto Buratto, Daniele Mammoli, Estel Canet Martinez

Para-water is an analogue of para-hydrogen, where the two proton spins are in a quantum state that is antisymmetric under permutation, also known as singlet state. The populations of the nuclear spin states in para-water are believed to have long lifetimes ...

Royal Society of Chemistry2015

Measuring absolute spin polarization in dissolution-DNP by Spin PolarimetrY Magnetic Resonance (SPY-MR)

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Quentin Chappuis

Dynamic nuclear polarization at 1.2 K and 6.7 T allows one to achieve spin temperatures on the order of a few millikelvin, so that the high-temperature approximation (Delta E < kT) is violated for the nuclear Zeeman interaction Delta E = gamma B(0)h/(2 pi) ...

Academic Press Inc - Elsevier Science2015

Deuterium MAS NMR Studies of Dynamics on Multiple Timescales: Histidine and Oxalic Acid

Geoffrey Bodenhausen

Deuterium (H-2) magic-angle spinning (MAS) nuclear magnetic resonance is applied to monitor the dynamics of the exchanging labile deuterons of polycrystalline L-histidine hydrochloride monohydrate-d(7) and -oxalic acid dihydrate-d(6). Direct experimental e ...

Wiley-Blackwell2015

Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

Natural abundance C-13 NMR spectra of biological extracts are recorded in a single scan provided that the samples are hyperpolarized by dissolution dynamic nuclear polarization combined with cross polarization. Heteronuclear 2D correlation spectra of hyper ...

Royal Society of Chemistry2015

Insights into the Catalytic Activity of Nitridated Fibrous Silica (KCC-1) Nanocatalysts from N-15 and Si-29 NMR Spectroscopy Enhanced by Dynamic Nuclear Polarization

Geoffrey Bodenhausen, Diego Carnevale, Angel Joaquin Perez Linde

Fibrous nanosilica (KCC-1) oxynitrides are promising solid-base catalysts. Paradoxically, when their nitrogen content increases, their catalytic activity decreases. This counterintuitive observation is explained here for the first time using N-15-solid-sta ...

Wiley-Blackwell2015

Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation

Geoffrey Bodenhausen, Fabien Ferrage, Nicola Salvi

Intrinsically disordered proteins and intrinsically disordered regions (IDRs) are ubiquitous in the eukaryotic proteome. The description and understanding of their conformational properties require the development of new experimental, computational, and th ...

Elsevier2015

Hyperpolarization of Deuterated Metabolites via Remote Cross-Polarization and Dissolution Dynamic Nuclear Polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

In deuterated molecules such as [1-C-13]pyruvate-d(3), the nuclear spin polarization of C-13 nuclei can be enhanced by combining Hartmann-Hahn cross-polarization (CP) at low temperatures (1.2 K) with dissolution dynamic nuclear polarization (D-DNP). The po ...

American Chemical Society2014

Procédé de spectroscopie RMN avec dégradations d'induction prolongée de cohérences aux temps de vie longs

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

A Method for nuclear magnetic resonance (NMR) spectroscopy of a sample comprising the following steps: (a) excitation of long lived coherences (LLC) between the singlet state So and the central triplet state To of nuclei of the sample by initiating irradia ...

2014

Toward Quantitative Measurements of Enzyme Kinetics by Dissolution Dynamic Nuclear Polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Daniel Abergel

Dissolution dynamic nuclear polarization (D-DNP) experiments enabled us to study the kinetics of the enzymatic phosphorylation reaction of glucose to form glucose-6-phosphate (G6P) by hexokinase (HK), with or without the presence of an excess of G6P, which ...

2014

Probing Al-27-C-13 proximities in metal-organic frameworks using dynamic nuclear polarization enhanced NMR spectroscopy

Geoffrey Bodenhausen, Diego Carnevale

We show how Al-27-C-13 proximities in the microporous metal-organic framework MIL-100(Al) can be probed using advanced Al-27-C-13 NMR methods boosted by Dynamic Nuclear Polarization. ...

Royal Society of Chemistry2014

Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR

Geoffrey Bodenhausen, Sandrine Gerber, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Nicola Salvi, Solène Marcelle Françoise Marie Passemard, Roberto Buratto, Aurélien Laguerre, Daniele Mammoli, Maninder Singh

Transverse and longitudinal relaxation times (T11 and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. ...

Wiley-Blackwell2014

Determination of sample temperature in unstable static fields by combining solid-state Br-79 and C-13 NMR

Geoffrey Bodenhausen

Monitoring the isotropic chemical shifts to calibrate the sample temperature presupposes a perfect stability of the static magnetic field. It can be difficult to satisfy this requirement in solid-state NMR measurements. This paper describes a simple way to ...

Academic Press Inc - Elsevier Science2014

Cross polarization from H-1 to quadrupolar Li-6 nuclei for dissolution DNP

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Angel Joaquin Perez Linde

Cross polarization from protons to quadrupolar Li-6 nuclei is combined with dynamic nuclear polarization of protons at 1.2 K and 6.7 T using TEMPOL as a polarizing agent followed by rapid dissolution. Compared to direct Li-6 DNP without cross-polarization, ...

Royal Society of Chemistry2014

Method for hyperpolarization transfer in the liquid state

Geoffrey Bodenhausen, Sami Jannin

A method for producing a hyperpolarized sample for use in a magnetic resonance investigation, with the following steps: a) providing a solid sample (50), containing long T1 nuclei and short T1 nuclei in the same molecules (51) b) hyperpolarizing the short ...

2014

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