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Geoffrey Bodenhausen

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Publications associées (143)

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Sensitivity improvement during heteronuclear spin decoupling in solid-state nuclear magnetic resonance experiments at high spinning frequencies and moderate radio-frequency amplitudes

Geoffrey Bodenhausen

Searching for optimal conditions during one- and multi-dimensional solid-state NMR experiments in high static fields may require spinning the sample at frequencies above 40 kHz. This implies challenging requirements for heteronuclear spin decoupling. We ha ...

Elsevier2014

Hyperpolarized Water to Study Protein-Ligand Interactions

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

The affinity between a chosen target protein and small molecules is a key aspect of drug discovery. Screening by popular NMR methods such as Water-LOGSY suffers from low sensitivity and from false positives caused by aggregated or denatured proteins. This ...

2015

A synthetic zwitterionic water channel: Characterization in the solid state by X-ray crystallography and NMR spectroscopy

Paul Joseph Dyson, Rosario Scopelliti, Geoffrey Bodenhausen, Dongbin Zhao

Wiley-VCH Verlag GmbH2005

Cross-correlated relaxation measurements under adiabatic sweeps: determination of local order in proteins

Geoffrey Bodenhausen, Nicola Salvi, Pavel Kaderavek

Adiabatically swept pulses were originally designed for the purpose of broadband spin inversion. Later, unexpected advantages of their utilization were also found in other applications, such as refocusing to excite spin echoes, studies of chemical exchange ...

Springer Verlag2015

Measurement of Slow Diffusion Coefficients of Molecules with Arbitrary Scalar Couplings via Long-Lived Spin States

Geoffrey Bodenhausen, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja

New experiments are described for the determination of very slow diffusion constants by nuclear magnetic resonance (NMR) using long-lived (singlet) states. These experiments are suitable for molecules or conformations featuring a wide range of J-couplings. ...

2008

Fourier tickling for homonuclear decoupling in nmr

Geoffrey Bodenhausen, Diego Carnevale

PROBLEM TO BE SOLVED: To provide an effective and speedy method for decoupling of homonuclear couplings.SOLUTION: This invention concerns a method for high resolution NMR (nuclear magnetic resonance) measurements comprising the application of excitation pu ...

2013

Evidence for Dynamics on a 100 ns Time Scale from Single- and Double-Quantum Nitrogen-14 NMR in Solid Peptides

Geoffrey Bodenhausen, Simone Cavadini, Simone Ulzega

The indirect detection of 14N spectra via protons in the manner of heteronuclear multiple-quantum correlation (HMQC) allows one to obtain single- (SQ) and double-quantum (DQ) 14N spectra in solids. A comparison of the SQ and DQ line widths as a function of ...

2008

Method and device for rapid dnp

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

A method for producing hyperpolarized sample material for use in magnetic resonance investigations, with a) preparing a target material, containing high gamma nuclei with a short T1, - a polarizing agent with a broad EPR line, and low gamma nuclei with a l ...

2013

Scavenging Free Radicals To Preserve Enhancement and Extend Relaxation Times in NMR using Dynamic Nuclear Polarization

Rolf Gruetter, Geoffrey Bodenhausen, Arnaud Comment, Sandrine Gerber, Mor-Miri Mishkovsky, Sami Jannin, Pascal Miéville, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja

Vitamin C for longer lifetimes: N-oxide radicals that are widely used for dynamic nuclear polarization can be reduced by scavengers such as sodium ascorbate (vitamin C) during the dissolution process, thus diminishing losses of polarization during the tran ...

Wiley-Blackwell2010

Preservation of heteronuclear multiple-quantum coherences in NMR by double-resonance irradiation

Geoffrey Bodenhausen, Simone Ulzega, Mariachiara Verde

A heteronuclear double-resonance (HDR) method based on MLEV-32 or WALTZ-32 pulse sequences has been designed for the investigation of relaxation of heteronuclear multiple-quantum (MQ) coherences. The theoretical analysis of this technique uses average Hami ...

2009

Method for hyperpolarization transfer in the liquid state

Geoffrey Bodenhausen, Sami Jannin

A method for producing a hyperpolarized sample for use in a magnetic resonance investigation, with the following steps: a) providing a solid sample (50), containing long T1 nuclei and short T1 nuclei in the same molecules (51) b) hyperpolarizing the short ...

2014

Insights into the Catalytic Activity of Nitridated Fibrous Silica (KCC-1) Nanocatalysts from N-15 and Si-29 NMR Spectroscopy Enhanced by Dynamic Nuclear Polarization

Geoffrey Bodenhausen, Diego Carnevale, Angel Joaquin Perez Linde

Fibrous nanosilica (KCC-1) oxynitrides are promising solid-base catalysts. Paradoxically, when their nitrogen content increases, their catalytic activity decreases. This counterintuitive observation is explained here for the first time using N-15-solid-sta ...

Wiley-Blackwell2015

Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation

Geoffrey Bodenhausen, Nicola Salvi

Intrinsically disordered proteins and intrinsically disordered regions (IDRs) are ubiquitous in the eukaryotic proteome. The description and understanding of their conformational properties require the development of new experimental, computational, and th ...

Elsevier2015

QUADRUPOLAR NUCLEI NMR USING RESIDUAL DIPOLAR COUPLINGS

Geoffrey Bodenhausen

Method for obtaining two-dimensional nuclear magnetic resonance spectrum of quadrupolar nuclei of nitrogen-14, involves recording signal of neighboring nucleus with specific spin after specific duration ...

2005

A bright future for magnetic resonance

Geoffrey Bodenhausen

This contribution seeks to identify a few factors that have contributed to the success of a thriving discipline, and to identify threats that could put future prospects at risk. Many of these factors are not specific to magnetic resonance, and may also app ...

Springer2015

Slow motions in nondeuterated proteins: Concerted chemical shift modulations of backbone nuclei

Geoffrey Bodenhausen, Chiara Perazzolo, Julien Wist

Springer, Springer-Verlag2005

Hyperpolarizing Gases via Dynamic Nuclear Polarization and Sublimation

Rolf Gruetter, Geoffrey Bodenhausen, Jean-Philippe Ansermet, Arnaud Comment, François Lazeyras, Sami Jannin, Pascal Miéville, Riddhiman Sarkar, Paul Romeo Vasos, Jean-Noël Hyacinthe, Puneet Ahuja

A high throughput method was designed to produce hyperpolarized gases by combining lowtemperature dynamic nuclear polarization with a sublimation procedure. It is illustrated by applications to 129Xe nuclear magnetic resonance in xenon gas, leading to a si ...

American Physical Society2010

Rotation-induced recovery and bleaching in magnetic resonance

Geoffrey Bodenhausen, Diego Carnevale, Angel Joaquin Perez Linde, Srinivas Chinthalapalli

Thurber and Tycko recently described a 'bleaching effect' that occurs in magnetic resonance when solid samples that are doped with paramagnetic agents are subjected to rotation by magic angle spinning (MAS) in a static magnetic field with a rotation period ...

Royal Society of Chemistry2015

Slow Diffusion by Singlet State NMR Spectroscopy

Geoffrey Bodenhausen, Simone Cavadini

Small diffusion coeffs. can be measured by using populations of singlet states that have a relaxation time const., Ts, which can be much longer than the longitudinal relaxation time, T1. Spatial information can be encoded with pulsed field gradients in the ...

2005

Proton NMR of15N-choline metabolites enhanced by dynamic nuclear polarization

Rolf Gruetter, Geoffrey Bodenhausen, Arnaud Comment, Sami Jannin, Riddhiman Sarkar, Paul Romeo Vasos

(Figure Presented) Chemical shifts of protons can report on metabolic transformations such as the conversion of choline to phosphocholine. To follow such processes in vivo, magnetization can be enhanced by dynamic nuclear polarization (DNP). We have hyperp ...

2009