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Geoffrey Bodenhausen

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Related publications (143)

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Hyperpolarization of Deuterated Metabolites via Remote Cross-Polarization and Dissolution Dynamic Nuclear Polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

In deuterated molecules such as [1-C-13]pyruvate-d(3), the nuclear spin polarization of C-13 nuclei can be enhanced by combining Hartmann-Hahn cross-polarization (CP) at low temperatures (1.2 K) with dissolution dynamic nuclear polarization (D-DNP). The po ...

American Chemical Society2014

On toxic effects of scientific journals

Geoffrey Bodenhausen

The advent of online publishing greatly facilitates the dissemination of scientific results. This revolution might have led to the untimely death of many traditional publishing companies, since today's scientists are perfectly capable of writing, formattin ...

Indian Academy of Science2013

Time Scales of Slow Motions in Ubiquitin Explored by Heteronuclear Double Resonance

Geoffrey Bodenhausen, Nicola Salvi, Simone Ulzega

Understanding how proteins function at the atomic level relies in part on a detailed characterization of their dynamics. Ubiquitin, a small single-domain protein, displays rich dynamic properties over a wide range of time scales. In particular, several reg ...

2012

Composite pulses for efficient excitation of half-integer quadrupolar nuclei in NMR of static and spinning solid samples

Geoffrey Bodenhausen, Diego Carnevale

Composite pulses of the type (tau(p))(x)(2 tau(p))(-x)(3 tau(p))(x) allow one to excite the central transition of nuclei with half-integer spin with enhanced efficiency compared to a simple (tau(sp)(p))(x) pulse. The method has been tested on solid samples ...

Elsevier2012

Determination of sample temperature in unstable static fields by combining solid-state Br-79 and C-13 NMR

Geoffrey Bodenhausen

Monitoring the isotropic chemical shifts to calibrate the sample temperature presupposes a perfect stability of the static magnetic field. It can be difficult to satisfy this requirement in solid-state NMR measurements. This paper describes a simple way to ...

Academic Press Inc - Elsevier Science2014

Method for the nmr based determination of the affinity of drugs for a target protein

Geoffrey Bodenhausen, Aurélien Bornet, Nicola Salvi, Roberto Buratto

The document relates to a method for the determination of the binding properties of at least one first chemical compound to at least one second chemical compound between a free essentially dissociated state and a bound essentially associated state by using ...

2013

Method for nuclear magnetic resonance (NMR) spectroscopy measurements using long-lived coherences (LLC)

Geoffrey Bodenhausen, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja

A method for nuclear magnetic resonance (NMR) spectroscopy of a sample comprises preparation of the sample and carrying out an NMR spectroscopy measurement. Preparation includes excitation of long lived coherences (LLC) between the singlet state S0 and the ...

2013

Uniform broadband excitation of crystallites in rotating solids using interleaved sequences of delays alternating with nutation

Geoffrey Bodenhausen, Marc Anthony Caporini, Simone Ulzega

In solids that are spinning about the magic angle, trains of short pulses in the manner of Delays Alternating with Nutations for Tailored Excitation (DANTE) allow one to improve the efficiency of the excitation of magnetization compared to rectangular puls ...

Academic Press Inc - Elsevier Science2012

Measuring absolute spin polarization in dissolution-DNP by Spin PolarimetrY Magnetic Resonance (SPY-MR)

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

Dynamic nuclear polarization at 1.2 K and 6.7 T allows one to achieve spin temperatures on the order of a few millikelvin, so that the high-temperature approximation (Delta E < kT) is violated for the nuclear Zeeman interaction Delta E = gamma B(0)h/(2 pi) ...

Academic Press Inc - Elsevier Science2015

Cross-encoded magnetic resonance imaging in inhomogeneous fields

Geoffrey Bodenhausen

In magnetic resonance imaging (MRI), it is possible to cancel the effects of severe inhomogeneities of the magnetic field even if the field profile is unknown. The new ‘cross-encoded’ method is based on adiabatic frequency-modulated pulses combined with tw ...

Academic Press Inc - Elsevier Science2009

Boosting the Sensitivity of Ligand-Protein Screening by NMR of Long-Lived States

Geoffrey Bodenhausen, Christian Heinis, Aurélien Bornet, Nicola Salvi, Simone Ulzega, Alessandro Angelini, Roberto Buratto, Inmaculada Rentero Rebollo

A new NMR method for the study of ligand protein interactions exploits the unusual lifetimes of long-lived states (LLSs). The new method provides better contrast between bound and free ligands and requires a protein-ligand ratio ca. 25 times lower than for ...

2012

Bibliometrics as Weapons of Mass Citation - La bibliométrie comme arme de citation massive

Geoffrey Bodenhausen

The allocation of resources for research is increasingly based on so-called ‘bibliometrics’. Scientists arenow deemed to be successful on the sole condition that their work be abundantly cited. This world-wide trendappears to enjoy support not only by gran ...

Schweizerische Chemische Gesellschaft2010

Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Pascal Miéville, Basile Vuichoud, Florian Patrick Marie Daniel De la Barre De Nanteuil, Estel Canet Martinez, Xiao Ji

Hyperpolarization is generated by dissolution dynamic nuclear polarization (d-DNP) using a polymer-based polarizing agent dubbed FLAP (filterable labeled agents for polarization). It consists of a thermo-responsive poly(N-isopropylacrylamide), also known a ...

Wiley-V C H Verlag Gmbh2016

Structured and porous materials particularly suitable as polarizing agents in dissolution dynamic nuclear polarization

David Lyndon Emsley, Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

The present invention concerns materials consisting in a porous and structured network, this network being at least in part formed by Si atoms, or Si atoms and metal atoms, linked to each other by oxy bridges, comprising organic molecules which include at ...

2016

Dynamic nuclear polarization of quadrupolar nuclei using cross polarization from protons: surface-enhanced aluminium-27 NMR

Geoffrey Bodenhausen, David Lyndon Emsley, Pascal Miéville, Diego Carnevale, Aaron James Rossini, Marc Anthony Caporini

The surface of gamma-alumina nanoparticles can be characterized by dynamic nuclear polarization (DNP) surface-enhanced NMR of Al-27. DNP is combined with cross-polarization and MQ-MAS to determine local symmetries of Al-27 sites at the surface. ...

Royal Society of Chemistry2012

Mesoporous Silica Nanoparticles Loaded with Surfactant: Low Temperature Magic Angle Spinning C-13 and Si-29 NMR Enhanced by Dynamic Nuclear Polarization

Geoffrey Bodenhausen, Diego Carnevale

We show that dynamic nuclear polarization (DNP) can be used to enhance NMR signals of C-13 and Si-29 nuclei located in mesoporous organic/inorganic hybrid materials, at several hundreds of nanometers from stable radicals (TOTAPOL) trapped in the surroundin ...

American Chemical Society2013

Improving resolution in single-scan 2D spectroscopy

Geoffrey Bodenhausen

New schemes are introduced that allow one to improve the resolution in the indirect dimension of single-scan 'ultrafast' two-dimensional NMR spectra. The methods combine undersampling with band-selective pulses to recover signals that lie outside the detec ...

Academic Press Inc - Elsevier Science2008

Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR

Geoffrey Bodenhausen, Sandrine Gerber, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Solène Marcelle Françoise Marie Passemard, Daniele Mammoli, Nicola Salvi, Roberto Buratto

Transverse and longitudinal relaxation times (T11 and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. ...

Wiley-Blackwell2014

Molecular Properties Determined from Relaxation of Long-Lived Spin States

Geoffrey Bodenhausen, Riddhiman Sarkar, Paul Romeo Vasos, Puneet Ahuja

The populations of long-lived spin states, in particular, populations of singlet states that are comprised of antisymmetric combinations of product states, ∣αIβS⟩−∣βIαS⟩, are characterized by very long lifetimes because the dipole-dipole interaction betwee ...

2007

Kinetics of Yttrium-Ligand Complexation Monitored Using Hyperpolarized 89Y as a Model for Gadolinium in Contrast Agents

Geoffrey Bodenhausen, Lothar Helm, Sami Jannin, Pascal Miéville

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) enhances Y-89 spin magnetization by 3 to 4 orders of magnitude and provides a way to monitor yttrium-ligand complexation "on the fly" by means of Y-89 NMR. In this communication, we show a ...

American Chemical Society2010