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Alfio Quarteroni

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Publications associées (251)

Fluid-structure interaction analysis of transcatheter aortic valve implantation

Alfio Quarteroni

Transcatheter aortic valve implantation (TAVI) is a minimally invasive intervention for the treatment of severe aortic valve stenosis. The main cause of failure is the structural deterioration of the implanted prosthetic leaflets, possibly inducing a valvu ...

Wiley2023

A mathematical model of the human heart suitable to address clinical problems

Alfio Quarteroni

In this paper, we present a mathematical model capable of simulating the human cardiac function. We review the basic equations of the model, their coupling, the numerical approach for the computer solution of this mathematical model, and a few examples of ...

SPRINGER JAPAN KK2023

lifex-ep: a robust and efficient software for cardiac electrophysiology simulations

Alfio Quarteroni, Francesco Regazzoni, Marco Fedele, Stefano Pagani

Background: Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated endeavors ...

BMC2023

Impact of atrial fibrillation on left atrium haemodynamics: A computational fluid dynamics study

Alfio Quarteroni, Luca Dede'

We analyse the haemodynamics of the left atrium, highlighting differences between healthy individuals and patients affected by atrial fibrillation. The computational study is based on patient-specific geometries of the left atria to simulate blood flow dyn ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Spectral element numerical simulation of the 2009 L'Aquila earthquake on a detailed reconstructed domain

Alfio Quarteroni

In this paper, we simulate the earthquake that hit the city of L'Aquila on 2009 April 6 using SPEED (SPectral Elements in Elastodynamics with Discontinuous Galerkin), an open-source code able to simulate the propagation of seismic waves in complex 3-D doma ...

OXFORD UNIV PRESS2022

Universal Solution Manifold Networks (USM-Nets): Non-Intrusive Mesh-Free Surrogate Models for Problems in Variable Domains

Alfio Quarteroni

We introduce universal solution manifold network (USM-Net), a novel surrogate model, based on artificial neural networks (ANNs), which applies to differential problems whose solution depends on physical and geometrical parameters. We employ a mesh-less arc ...

ASME2022

PDE-Aware Deep Learning for Inverse Problems in Cardiac Electrophysiology

Alfio Quarteroni, Simone Deparis, Stefano Pagani, Riccardo Tenderini

In this work, we present a PDE-aware deep learning model for the numerical solution to the inverse problem of electrocardiography. The model both leverages data availability and exploits the knowledge of a physically based mathematical model, expressed by ...

2022

Electrogram fractionation during sinus rhythm occurs in normal voltage atrial tissue in patients with atrial fibrillation

Alfio Quarteroni

Introduction Electrogram (EGM) fractionation is often associated with diseased atrial tissue; however, mechanisms for fractionation occurring above an established threshold of 0.5 mV have never been characterized. We sought to investigate during sinus rhyt ...

WILEY2022

A Geometric Multiscale Model For The Numerical Simulation Of Blood Flow In The Human Left Heart

Alfio Quarteroni

We present a new computational model for the numerical simulation of blood flow in the human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian Eulerian formulation to account for the endocardium motion and we model the ...

AMER INST MATHEMATICAL SCIENCES-AIMS2022

A fast cardiac electromechanics model coupling the Eikonal and the nonlinear mechanics equations

Alfio Quarteroni

We present a new model of human cardiac electromechanics for the left ventricle where electrophysiology is described by a Reaction-Eikonal model and which enables an off-line resolution of the reaction model, thus entailing a big saving of computational ti ...

2022

Computational electrophysiology of the coronary sinus branches based on electro-anatomical mapping for the prediction of the latest activated region

Fabio Nobile, Alfio Quarteroni

This work dealt with the assessment of a computational tool to estimate the electrical activation in the left ventricle focusing on the latest electrically activated segment (LEAS) in patients with left bundle branch block and possible myocardial fibrosis. ...

2022

The role of mechano-electric feedbacks and hemodynamic coupling in scar-related ventricular tachycardia

Alfio Quarteroni, Luca Dede', Stefano Pagani

Mechano-electric feedbacks (MEFs), which model how mechanical stimuli are transduced into electrical signals, have received sparse investigation by considering electromechanical simulations in simplified scenarios. In this paper, we study the effects of di ...

2022

Partitioned and Monolithic Algorithms for the Numerical Solution of Cardiac Fluid-Structure Interaction

Alfio Quarteroni

We review and compare different fluid-structure interaction (FSI) numerical methods in the context of heart modeling, aiming at assessing their computational ef-ficiency for cardiac numerical simulations and selecting the most appropriate method for heart ...

GLOBAL SCIENCE PRESS2022

Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy

Alfio Quarteroni

Hypertrophic Cardiomyopathy (HCM) is a pathological condition characterized by an abnormal thickening of the myocardium. When affecting the medio-basal portion of the septum, it is named Hypertrophic Obstructive Cardiomyopathy (HOCM) because it induces a f ...

FRONTIERS MEDIA SA2022

Modeling The Cardiac Electromechanical Function: A Mathematical Journey

Alfio Quarteroni

In this paper we introduce the electromechanical mathematical model of the human heart. After deriving it from physical first principles, we discuss its mathematical properties and the way numerical methods can be set up to obtain numerical approximations ...

AMER MATHEMATICAL SOC2022

A machine learning method for real-time numerical simulations of cardiac electromechanics

Alfio Quarteroni

We propose a machine learning-based method to build a system of differential equations that approximates the dynamics of 3D electromechanical models for the human heart, accounting for the dependence on a set of parameters. Specifically, our method permits ...

ELSEVIER SCIENCE SA2022

Prediction of myocardial blood flow under stress conditions by means of a computational model

Alfio Quarteroni

Purpose Quantification of myocardial blood flow (MBF) and functional assessment of coronary artery disease (CAD) can be achieved through stress myocardial computed tomography perfusion (stress-CTP). This requires an additional scan after the resting corona ...

SPRINGER2022

Slow Conduction Corridors and Pivot Sites Characterize the Electrical Remodeling in Atrial Fibrillation

Alfio Quarteroni

OBJECTIVES This study aimed to evaluate the progression of electrophysiotogicat phenomena in a cohort of patients with paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation (PsAF). BACKGROUND Electrical remodeling has been conjectured to ...

2022

Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function

Alfio Quarteroni

In order to simulate the cardiac function for a patient-specific geometry, the generation of the computational mesh is crucially important. In practice, the input is typically a set of unprocessed polygonal surfaces coming either from a template geometry o ...

Wiley2021

Data integration for the numerical simulation of cardiac electrophysiology

Alfio Quarteroni, Luca Dede', Andrea Manzoni, Stefano Pagani

The increasing availability of extensive and accurate clinical data is rapidly shaping cardiovascular care by improving the understanding of physiological and pathological mechanisms of the cardiovascular system and opening new frontiers in designing thera ...

WILEY2021

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