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Alfio Quarteroni

Cette personne a quitté l’EPFL

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Publications associées (246)

Page 3 sur 13

Slow Conduction Corridors and Pivot Sites Characterize the Electrical Remodeling in Atrial Fibrillation

Alfio Quarteroni

OBJECTIVES This study aimed to evaluate the progression of electrophysiotogicat phenomena in a cohort of patients with paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation (PsAF). BACKGROUND Electrical remodeling has been conjectured to ...

2022

A multiscale Darcy-Brinkman model for fluid flow in fractured porous media

Alfio Quarteroni, Carlo D'Angelo, Matteo Lesinigo

The aim of this work is to present a reduced mathematical model for describing fluid flow in porous media featuring open channels or fractures. The Darcy's law is assumed in the porous domain while the Stokes-Brinkman equations are considered in the fractu ...

Springer2011

Accurate and efficient evaluation of failure probability for partial different equations with random input data

Alfio Quarteroni, Peng Chen

Several computational challenges arise when evaluating the failure probability of a given system in the context of risk prediction or reliability analysis. When the dimension of the uncertainties becomes high, well established direct numerical methods can ...

Elsevier Science Sa2013

Isogeometric Analysis of the electrophysiology in the human heart: Numerical simulation of the bidomain equations on the atria

Alfio Quarteroni, Luca Dede', Luca Pegolotti

We consider Isogeometric Analysis (IGA) for the numerical solution of the electrophysiology of the atria, which in this work is modeled by means of the bidomain equations on thin surfaces. First, we consider the bidomain equations coupled with the Roger-Mc ...

ELSEVIER SCIENCE SA2019

Influence of cellular mechano-calcium feedback in numerical models of cardiac electromechanics

Alfio Quarteroni

Multiphysics and multiscale mathematical models enable the non-invasive study of cardiac function. These models often rely on simplifying assumptions that neglect certain biophysical processes to balance fidelity and computational cost. In this work, we pr ...

2025

Discontinuous Galerkin methods for Fisher-Kolmogorov equation with application to a-synuclein spreading in Parkinson's disease

Alfio Quarteroni, Francesca Bonizzoni

This spreading of prion proteins is at the basis of brain neurodegeneration. This paper deals with the numerical modelling of the misfolding process of a-synuclein in Parkinson's disease. We introduce and analyse a discontinuous Galerkin method for the sem ...

Elsevier Science Sa2023

Spectral element numerical simulation of the 2009 L'Aquila earthquake on a detailed reconstructed domain

Alfio Quarteroni

In this paper, we simulate the earthquake that hit the city of L'Aquila on 2009 April 6 using SPEED (SPectral Elements in Elastodynamics with Discontinuous Galerkin), an open-source code able to simulate the propagation of seismic waves in complex 3-D doma ...

OXFORD UNIV PRESS2022

Comparisons between reduced order models and full 3D models for fluid-structure interaction problems in haemodynamics

Alfio Quarteroni, Simone Deparis, Claudia Maria Colciago

When modelling the cardiovascular system, the effect of the vessel wall on the blood flow has great relevance. Arterial vessels are complex living tissues and three-dimensional specific models have been proposed to represent their behaviour. The numerical ...

Elsevier2014

A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation

Luca Barbarotta, Alfio Quarteroni, Luca Dede', Simone Rossi

Models for cardiac mechanics require an activation mechanism properly representing the stress-strain relations in the contracting myocardium. In this paper, we propose a new activation model that accounts for the transmural heterogeneities observed in myoc ...

Wiley2018

Computational haemodynamics for pulmonary valve replacement by means of a reduced fluid-structure interaction model

Alfio Quarteroni

Pulmonary valve replacement (PVR) consists of substituting a patient's original valve with a prosthetic one, primarily addressing pulmonary valve insufficiency, which is crucially relevant in Tetralogy of Fallot repairment. While extensive clinical and com ...

Wiley2024

An orthotropic active-strain model for the myocardium mechanics and its numerical approximation

Alfio Quarteroni

In the wide literature devoted to the cardiac structural mechanics, the strain energy proposed by Holzapfel and Ogden exhibits a number of interesting features: it has suitable mathematical properties and it is based on few material parameters that can, in ...

Gauthier-Villars/Editions Elsevier2014

Geometric multiscale modeling of the cardiovascular system, between theory and practice

Alfio Quarteroni, Christian Vergara

This review paper addresses the so called geometric multiscale approach for the numerical simulation of blood flow problems, from its origin (that we can collocate in the second half of '90s) to our days. By this approach the blood fluid-dynamics in the wh ...

Elsevier2016

A new algorithm for high-dimensional uncertainty quantification based on dimension-adaptive sparse grid approximation and reduced basis methods

Alfio Quarteroni, Peng Chen

In this work we develop an adaptive and reduced computational algorithm based on dimension-adaptive sparse grid approximation and reduced basis methods for solving highdimensional uncertainty quantification (UQ) problems. In order to tackle the computation ...

Elsevier2015

An integrated heart-torso electromechanical model for the simulation of electrophysiological outputs accounting for myocardial deformation

Alfio Quarteroni

When generating in-silico clinical electrophysiological outputs, such as electrocardiograms (ECGs) and body surface potential maps (BSPMs), mathematical models have relied on single physics, i.e. of the cardiac electrophysiology (EP), neglecting the role o ...

Elsevier Science Sa2024

A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

Alfio Quarteroni, Andrea Manzoni

In the context of cardiac electrophysiology, we propose a novel computational approach to highlight and explain the long-debated mechanisms behind atrial fibrillation (AF) and to reliably numerically predict its induction and sustainment. A key role is pla ...

FRONTIERS MEDIA SA2021

Computational comparison of aortic root stresses in presence of stentless and stented aortic valve bio-prostheses

Alfio Quarteroni, Christian Vergara, Elena Faggiano

We provide a computational comparison of the performance of stentless and stented aortic prostheses, in terms of aortic root displacements and internal stresses. To this aim, we consider three real patients; for each of them, we draw the two prostheses con ...

Taylor & Francis Ltd2017

Improved hybrid/GPU algorithm for solving cardiac electrophysiology problems on Purkinje networks

Alfio Quarteroni, Christian Vergara, Toni Mikael Lassila

Cardiac Purkinje fibers provide an important pathway to the coordinated contraction of the heart. We present a numerical algorithm for the solution of electrophysiology problems across the Purkinje network that is efficient enough to be used in in silico s ...

Wiley2017

Coupled models for integrated heart simulations: a numerical study of the fluid dynamics in the left ventricle

Alfio Quarteroni, Simone Deparis, Luca Dede', Davide Forti, Antonello Gerbi

We consider the numerical simulation of integrated heart models for the study of the cardiac functioning with particular emphasis on the coupling of the muscle contraction, the fluid dynamics of the left ventricle, and the interaction with the valves. We a ...

CMBE, Zeta Computational Resources Ltd.2015

Computational study of the risk of restenosis in coronary bypasses

Alfio Quarteroni, Christian Vergara

Coronary artery disease, caused by the buildup of atherosclerotic plaques in the coronary vessel wall, is one of the leading causes of death in the world. For high-risk patients, coronary artery bypass graft is the preferred treatment. Despite overall exce ...

Springer Heidelberg2017

Efficient oxygen transfer by surface aeration in shaken cylindrical containers for mammalian cell cultivation at volumetric scales up to 1,000 liters

Alfio Quarteroni, Florian Maria Wurm, David Hacker, Xiuwei Zhang, Marco Discacciati, Mathieu Benjamin Stettler, Nicola Parolini

Cylindrical containers agitated by orbital shaking are being developed as simple and cost-effective bioreactor systems for the cultivation of mammalian cells. Here the oxygen transfer capacities of containers with nominal volumes from 50 mL to 2000 L were ...

2009