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Alfio Quarteroni

Cette personne a quitté l’EPFL

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Publications associées (246)

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Mathematical and numerical models for transfer of low-density lipoproteins through the arterial walls: A new methodology for the model set up with applications to the study of disturbed lumenal flow

Alfio Quarteroni, Paolo Zunino

In this work we introduce and discuss several mathematical models, based on partial differential equations, devised to study the coupled transport of macromolecules as low-density lipoproteins in the blood stream and in the arterial walls. These models are ...

2005

Modeling the cardiac response to hemodynamic changes associated with COVID-19: a computational study

Alfio Quarteroni

Emerging studies address how COVID-19 infection can impact the human cardiovascular system. This relates particularly to the development of myocardial injury, acute coronary syndrome, myocarditis, arrhythmia, and heart failure. Prospective treatment approa ...

2021

A comprehensive mathematical model for cardiac perfusion

Alfio Quarteroni, Francesco Regazzoni, Christian Vergara

The aim of this paper is to introduce a new mathematical model that simulates myocardial blood perfusion that accounts for multiscale and multiphysics features. Our model incorporates cardiac electrophysiology, active and passive mechanics, hemodynamics, v ...

Nature Portfolio2023

Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function

Alfio Quarteroni

In order to simulate the cardiac function for a patient-specific geometry, the generation of the computational mesh is crucially important. In practice, the input is typically a set of unprocessed polygonal surfaces coming either from a template geometry o ...

Wiley2021

Biophysically detailed mathematical models of multiscale cardiac active mechanics

Alfio Quarteroni, Francesco Regazzoni

Author summary Computer-based numerical simulations of the heart are increasingly assuming a recognized role in the context of computational medicine and cardiology. They are based on mathematical models describing the different physical phenomena occurrin ...

2020

A semi-implicit approach for fluid-structure interaction based on an algebraic fractional step method

Alfio Quarteroni

We address the numerical simulation of fluid-structure interaction problems characterized by a strong added-mass effect. We propose a semi-implicit coupling scheme based on an algebraic fractional-step method. The basic idea of a semi-implicit scheme consi ...

2007

Computational electrophysiology of the coronary sinus branches based on electro-anatomical mapping for the prediction of the latest activated region

Alfio Quarteroni, Fabio Nobile

This work dealt with the assessment of a computational tool to estimate the electrical activation in the left ventricle focusing on the latest electrically activated segment (LEAS) in patients with left bundle branch block and possible myocardial fibrosis. ...

2022

A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

Alfio Quarteroni

While ventricular electromechanics is extensively studied in both physiological and pathological conditions, four-chamber heart models have only been addressed recently; most of these works however neglect atrial contraction. Indeed, as atria are character ...

ELSEVIER SCIENCE SA2023

Electrogram fractionation during sinus rhythm occurs in normal voltage atrial tissue in patients with atrial fibrillation

Alfio Quarteroni

Introduction Electrogram (EGM) fractionation is often associated with diseased atrial tissue; however, mechanisms for fractionation occurring above an established threshold of 0.5 mV have never been characterized. We sought to investigate during sinus rhyt ...

WILEY2022

Morphomechanical Model Of The Torsional C-Looping In The Embryonic Heart

Alfio Quarteroni

Before septation processes shape its four chambers, the embryonic heart is a straight tube that spontaneously bends and twists breaking the left-right symmetry. In particular, the heart tube is subjected to a cell remodeling inducing ventral bending and de ...

SIAM PUBLICATIONS2021

Reduced basis method for the Stokes equations in decomposable parametrized domains using greedy optimization

Alfio Quarteroni, Gianluigi Rozza, Laura Iapichino

Flow simulations in pipelined channels and several kinds of parametrized configurations have a growing interest in many life sciences and industrial applications. Applications may be found in the analysis of the blood flow in specific compartments of the c ...

Springer2014

An algebraic least squares reduced basis method for the solution of nonaffinely parametrized Stokes equations

Alfio Quarteroni, Simone Deparis, Andrea Manzoni, Niccolò Dal Santo

In this paper we propose a new, purely algebraic, Petrov-Galerkin reduced basis (RB) method to solve the parametrized Stokes equations, where parameters serve to identify the (variable) domain geometry. Our method is obtained as an algebraic least squares ...

ELSEVIER SCIENCE SA2019

Mathematical modelling of active contraction in isolated cardiomyocytes

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Simone Rossi, Aymen Laadhari

We investigate the interaction of intracellular calcium spatio-temporal variations with the self-sustained contractions in cardiac myocytes. A consistent mathematical model is presented considering a hyperelastic description of the passive mechanical prope ...

Oxford University Press2014

Coupling Biot and Navier-Stokes equations for modelling fluid-poroelastic media interaction

Alfio Quarteroni

The interaction between a fluid and a poroelastic structure is a complex problem that couples the Navier-Stokes equations with the Biot system. The finite element approximation of this problem is involved due to the fact that both subproblems are indefinit ...

Elsevier2009

Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy

Alfio Quarteroni

Hypertrophic Cardiomyopathy (HCM) is a pathological condition characterized by an abnormal thickening of the myocardium. When affecting the medio-basal portion of the septum, it is named Hypertrophic Obstructive Cardiomyopathy (HOCM) because it induces a f ...

FRONTIERS MEDIA SA2022

An Image-Based Computational Fluid Dynamics Study of Mitral Regurgitation in Presence of Prolapse

Alfio Quarteroni

PurposeIn this work we performed an imaged-based computational study of the systolic fluid dynamics in presence of mitral valve regurgitation (MVR). In particular, we compared healthy and different regurgitant scenarios with the aim of quantifying differen ...

SPRINGER2023

Space-time statistics of a linear dynamical energy cascade model dagger

Alfio Quarteroni

A linear dynamical model for the development of the turbulent energy cascade was introduced in Apolina ' rio et al. (J. Stat. Phys., 186, 15 (2022)). This partial differential equation, randomly stirred by a forcing term which is smooth in space and delta- ...

AMER INST MATHEMATICAL SCIENCES-AIMS2023

FaCSI: A block parallel preconditioner for fluid-structure interaction in hemodynamics

Alfio Quarteroni, Simone Deparis, Davide Forti, Gwenol Grandperrin

Modeling Fluid-Structure Interaction (FSI) in the vascular system is mandatory to reliably compute mechanical indicators in vessels undergoing large deformations. In order to cope with the computational complexity of the coupled 3D FSI problem after discre ...

Academic Press Inc Elsevier Science2016

Orthotropic active strain models for the numerical simulation of cardiac biomechanics

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Simone Rossi

An active strain formulation for orthotropic constitutive laws arising in cardiac mechanics modeling is introduced and studied. The passive mechanical properties of the tissue are described by the Holzapfel-Ogden relation. In the active strain formulation, ...

Wiley2012

Numerical simulation of left ventricular assist device implantations: comparing the ascending and the descending aorta cannulations

Alfio Quarteroni, Simone Deparis, Adelmo Cristiano Innocenza Malossi, Matteo Lesinigo, Jean Bonnemain

In this work we present numerical simulations of continuous flow left ventricle assist device implantation with the aim of comparing the ascending and the descending aorta anastomosis of outflow cannula. Despite the fact that the second approach is less in ...

Elsevier2013