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Alfio Quarteroni

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Publications associées (251)

A comprehensive stroke risk assessment by combining atrial computational fluid dynamics simulations and functional patient data

Alfio Quarteroni

Stroke, a major global health concern often rooted in cardiac dynamics, demands precise risk evaluation for targeted intervention. Current risk models, like the CHA 2 DS 2 -VASc \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepa ...

Nature Portfolio2024

Learning the intrinsic dynamics of spatio-temporal processes through Latent Dynamics Networks

Alfio Quarteroni, Francesco Regazzoni, Stefano Pagani

Predicting the evolution of systems with spatio-temporal dynamics in response to external stimuli is essential for scientific progress. Traditional equations-based approaches leverage first principles through the numerical approximation of differential equ ...

Nature Portfolio2024

A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

Alfio Quarteroni

While ventricular electromechanics is extensively studied in both physiological and pathological conditions, four-chamber heart models have only been addressed recently; most of these works however neglect atrial contraction. Indeed, as atria are character ...

ELSEVIER SCIENCE SA2023

Preserving the positivity of the deformation gradient determinant in intergrid interpolation by combining RBFs and SVD: Application to cardiac electromechanics

Alfio Quarteroni, Francesco Regazzoni

The accurate, robust and efficient transfer of the deformation gradient tensor between meshes of different resolution is crucial in cardiac electromechanics simulations. This paper presents a novel method that combines rescaled localized Radial Basis Funct ...

Elsevier Science Sa2023

lifex-cfd: An open-source computational fluid dynamics solver for cardiovascular applications

Alfio Quarteroni, Luca Dede', Marco Fedele

Computational fluid dynamics (CFD) is an important tool for the simulation of the cardiovascular function and dysfunction. Due to the complexity of the anatomy, the transitional regime of blood flow in the heart, and the strong mutual influence between the ...

Elsevier2023

Some evaluations of the fractional p-Laplace operator on radial functions

Alfio Quarteroni

We face a rigidity problem for the fractional p-Laplace operator to extend to this new framework some tools useful for the linear case. It is known that (-Delta)(s)(1 - vertical bar x vertical bar(2))(+)(s) and -Delta(p)(1 - vertical bar x vertical bar(p/p ...

AMER INST MATHEMATICAL SCIENCES-AIMS2023

lifex-fiber: an open tool for myofibers generation in cardiac computational models

Alfio Quarteroni

Background: Modeling the whole cardiac function involves the solution of several complex multi-physics and multi-scale models that are highly computationally demanding, which call for simpler yet accurate, high-performance computational tools. Despite the ...

BMC2023

A comprehensive mathematical model for cardiac perfusion

Alfio Quarteroni, Christian Vergara, Francesco Regazzoni

The aim of this paper is to introduce a new mathematical model that simulates myocardial blood perfusion that accounts for multiscale and multiphysics features. Our model incorporates cardiac electrophysiology, active and passive mechanics, hemodynamics, v ...

Nature Portfolio2023

Numerical modeling of the brain poromechanics by high-order discontinuous Galerkin methods

Alfio Quarteroni

We introduce and analyze a discontinuous Galerkin method for the numerical modeling of the equations of Multiple-Network Poroelastic Theory (MPET) in the dynamic formulation. The MPET model can comprehensively describe functional changes in the brain consi ...

WORLD SCIENTIFIC PUBL CO PTE LTD2023

Efficient and certified solution of parametrized one-way coupled problems through DEIM-based data projection across non-conforming interfaces

Alfio Quarteroni

One of the major challenges of coupled problems is to manage nonconforming meshes at the interface between two models and/or domains, due to different numerical schemes or domain discretizations employed. Moreover, very often complex submodels depend on (e ...

SPRINGER2023

A matrix-free high-order solver for the numerical solution of cardiac electrophysiology

Alfio Quarteroni

We propose a matrix-free solver for the numerical solution of the cardiac electrophysiology model consisting of the monodomain nonlinear reaction-diffusion equation coupled with a system of ordinary differential equations for the ionic species. Our numeric ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

A stable loosely-coupled scheme for cardiac electro-fluid-structure interaction

Alfio Quarteroni

We present a loosely coupled scheme for the numerical simulation of the cardiac electrofluid-structure interaction problem, whose solution is typically computationally intensive due to the need to suitably treat the coupling of the different submodels. Our ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

An Image-Based Computational Fluid Dynamics Study of Mitral Regurgitation in Presence of Prolapse

Alfio Quarteroni

PurposeIn this work we performed an imaged-based computational study of the systolic fluid dynamics in presence of mitral valve regurgitation (MVR). In particular, we compared healthy and different regurgitant scenarios with the aim of quantifying differen ...

SPRINGER2023

Space-time statistics of a linear dynamical energy cascade model dagger

Alfio Quarteroni

A linear dynamical model for the development of the turbulent energy cascade was introduced in Apolina ' rio et al. (J. Stat. Phys., 186, 15 (2022)). This partial differential equation, randomly stirred by a forcing term which is smooth in space and delta- ...

AMER INST MATHEMATICAL SCIENCES-AIMS2023

Discontinuous Galerkin methods for Fisher-Kolmogorov equation with application to a-synuclein spreading in Parkinson's disease

Alfio Quarteroni, Francesca Bonizzoni

This spreading of prion proteins is at the basis of brain neurodegeneration. This paper deals with the numerical modelling of the misfolding process of a-synuclein in Parkinson's disease. We introduce and analyse a discontinuous Galerkin method for the sem ...

Elsevier Science Sa2023

Optimized numerical solutions of SIRDVW multiage model controlling SARS-CoV-2 vaccine roll out: An application to the Italian scenario

Alfio Quarteroni, Nicola Parolini, Luca Dede'

In the context of SARS-CoV-2 pandemic, mathematical modelling has played a funda-mental role for making forecasts, simulating scenarios and evaluating the impact of pre-ventive political, social and pharmaceutical measures. Optimal control theory represent ...

KEAI PUBLISHING LTD2023

Efficient approximation of cardiac mechanics through reduced-order modeling with deep learning-based operator approximation

Alfio Quarteroni, Andrea Manzoni

Reducing the computational time required by high-fidelity, full-order models (FOMs) for the solution of problems in cardiac mechanics is crucial to allow the translation of patient-specific simulations into clinical practice. Indeed, while FOMs, such as th ...

Wiley2023

Fast and robust parameter estimation with uncertainty quantification for the cardiac function

Alfio Quarteroni

Background and objectives: Parameter estimation and uncertainty quantification are crucial in computa-tional cardiology, as they enable the construction of digital twins that faithfully replicate the behavior of physical patients. Many model parameters reg ...

ELSEVIER IRELAND LTD2023

Modeling isovolumetric phases in cardiac flows by an Augmented Resistive Immersed Implicit Surface method

Alfio Quarteroni

A major challenge in the computational fluid dynamics modeling of the heart function is the simulation of isovolumetric phases when the hemodynamics problem is driven by a prescribed boundary displacement. During such phases, both atrioventricular and semi ...

Wiley2023

A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

Alfio Quarteroni, Luca Dede'

We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and includes reduced models for cardiac valves and the circulatory system. Our mod ...

Wiley2023

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