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Martinus Gijs

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Publications associées (370)

Fast Immunohistochemical BioMarker Detection Device for Cancer Tissue Slices

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Bo Song, Ata Tuna Ciftlik, Hans-Anton Lehr

2010

Active microfluidic mixer using virtual source-sink pairs for DNA purification

Martinus Gijs, Caroline Vandevyver, Hüseyin Cumhur Tekin

We present an active mixer based on the creation of virtual source-sink pairs in a polydimethylsiloxane (PDMS) chip. Perfect mixing is achieved in only a sub-second time interval for a compact 5 μL mixing volume. This excellent performance is achieved than ...

2010

Subnanometer translation of microelectromechanical systems measured by discrete Fourier analysis of CCD images

Christophe Yamahata, Martinus Gijs

In-plane linear displacements of microelectromechanical systems are measured with subnanometer accuracy by observing periodic micropatterns with a CCD camera attached to an optical microscope. The translation of the microstructure is retrieved from the vid ...

Institute of Electrical and Electronics Engineers2010

Microfluidic applications of magnetic particles for biological analysis and catalysis

Martinus Gijs, Frédéric Lacharme, Ulrike Lehmann

American Chemical Society2010

Monolithic Silicon Chip for Immunofluorescence Detection on Single Magnetic Beads

Martinus Gijs, Caroline Vandevyver, Edoardo Charbon, Ulrike Lehmann, Emile Dupont

While fluorescence detection is widely used for bioassays owing to its high sensitivity, a complete fluorescent microscopy setup, comprised of a light source, optical filters, a microscope body, and a camera, still is bulky equipment, compromising its use ...

2010

Bioconjugated lanthanide luminescent helicates as multilabels for lab-on-a-chip detection of cancer biomarkers

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Anne-Sophie Chauvin, Venkataragavalu Sivagnanam, Bo Song, Vanesa Fernandez Moreira, Hans-Anton Lehr

The lanthanide binuclear helicate [Eu2(LC2(CO2H))3] is coupled to avidin to yield a luminescent bioconjugate EuB1 (Q ¼ 9.3%, s(5D0) ¼ 2.17 ms). MALDI/TOF mass spectrometry confirms the covalent binding of the Eu chelate and UV-visible spectroscopy allows o ...

2010

NOA 63 as a UV-curable material for fabrication of microfluidic channels with native hydrophilicity

Martinus Gijs, Raphaelle Luisier, Emile Dupont

In this paper, we propose a method to create a natively hydrophilic microfluidic structure in a fast and simple way using an UV-curable polymer (NOA 63 from Norland Optics). This polymer can provide a substitute to PDMS microchannels offering high reproduc ...

2010

Adaptive finite elements with large aspect ratio for electroosmotic and pressure-driven microflows

Marco Picasso, Martinus Gijs, Virabouth Prachittham

A space–time adaptive method is presented for the numerical simulation of mass transport in electroosmotic and pressure-driven microflows in two space dimensions. The method uses finite elements with large aspect ratio, which allows the electroosmotic flow ...

Wiley-Blackwell2010

Continuous flow sample washing and concentration in microfluidic channel using a magnetic beads “trapping-and-releasing” mechanism

Martinus Gijs

2010

Study of Spatio-Temporal Immunofluorescence on Bead Patterns in a Microfluidic Channel

Martinus Gijs, Venkataragavalu Sivagnanam, Hui Yang

We performed a direct immunoassay inside a microfluidic channel on patterned streptavidin-coated beads, which captured fluorescently-labeled biotin target molecules from a continuous flow. We arranged the beads in a dot array at the bottom of the channel a ...

American Institute of Physics2010

Microfluidic Protein Preconcentrator Using a Microchannel-Integrated Nafion Strip: Experiment and Modeling

Martinus Gijs, Venkataragavalu Sivagnanam, Meng Shen

We propose a simple microfluidic device for protein preconcentration based on the electrokinetic trapping principle. It comprises a narrow Nafion strip that is simply cut from a commercial membrane and is integrated into a molded poly(dimethylsiloxane) (PD ...

American Chemical Society2010

Magneto-microfluidic three-dimensional focusing of magnetic particles

Thomas Lehnert, Martinus Gijs, Yves Moser, Rana Afshar Ghasemlouy

We present a method for magneto-microfluidic three-dimensional focusing of magnetic microparticles from a dense plug into a single streamline with longitudinal inter-particle spacing. Plug formation on-chip is induced by a high-gradient magnetic field gene ...

Amer Inst Physics, 2 Huntington Quadrangle, Ste 1No1 D, Melville, Ny 11747-4501 Usa2010

A quadrupolar magnetic actuation system for superparamagnetic particles

Thomas Lehnert, Martinus Gijs, Yves Moser

2009

Monolithic micro-direct methanol fuel cell in PDMS with microfluidic channel-integrated Nafion strip

Martinus Gijs, Meng Shen

We demonstrate a monolithic polymer electrolyte membrane fuel cell by integrating a narrow (200 mu m) Nafion strip in a molded polydimethylsiloxane (PDMS) structure. We propose two designs, based on two 200 mu m-wide and two 80 mu m-wide parallel microflui ...

2009

Sandwich immunoassay on a microfluidic chip using patterns of electrostatically self-assembled streptavidin-coated beads

Martinus Gijs, Caroline Vandevyver, Frédéric Lacharme, Venkataragavalu Sivagnanam

In this paper, we demonstrate a bead-based microfluidic immunoassay using self-assembled streptavidin-coated bead micropatterns. The beads are assembled on the microfluidic channel surface using electrostatic forces between the negatively-charged streptavi ...

Elsevier2009

Dispositif de manipulation et de transport de perles magnetiques

Martinus Gijs, Amar Rida

A device for transporting magnetic or magnetisable microbeads ( 25 ) in a capillary chamber ( 14 ) comprises a permanent magnet ( 10 ) or an electromagnet ( 11 ) for subjecting the capillary chamber to a substantially uniform magnetic field, to apply a per ...

2009

Simultaneous magnetic particles washing and concentration in a microfluidic channel

Martinus Gijs

Purification of magnetic microparticles was demonstrated, with a purification efficiency of (72±14) % at a flow rate of 3 μl/min, in a microfluidic chip using a rotational magnetic system under continuous flow conditions. The rotation of a periodically arr ...

Elsevier2009

Controlled Microsynthesis of Silica Particles in a Microfluidic Setup

Martinus Gijs, Virendra Kumar Parashar, Josias Basil Wacker

We report on a novel microsynthesis method for easy controlling the size of silica micro- and nanoparticles. Colloids are synthesized in a microfluidic chamber by layer-wise adsorption of silica to precipitated nuclei. We prepare samples of spherical parti ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2009

Time-resolved lanthanide luminescence for lab-on-a-chip detection of biomarkers on cancerous tissues

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Venkataragavalu Sivagnanam, Bo Song, Hans-Anton Lehr

PDMS-based microfluidic devices combined with lanthanide-based immunocomplexes have been successfully tested for the multiplex detection of biomarkers on cancerous tissues, revealing an enhanced sensitivity compared to classical organic dyes. ...

2009

Quadrupolar magnetic actuation of superparamagnetic particles for enhanced microfluidic perfusion

Thomas Lehnert, Martinus Gijs, Yves Moser

We report on the magnetic actuation of superparamagnetic particles in a microfluidic channel. The formation of a highly confined and dynamic plug of particles extending over the cross section of the microchannel is enabled by superposing a static and a tim ...

AIP American Institute of Physics2009

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