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Martinus Gijs

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Publications associées (370)

On-chip microfluidic biocommunication assay for studying male-induced demise in C. elegans hermaphrodites

Thomas Lehnert, Martinus Gijs, Matteo Cornaglia, Li Dong

Like other animals, C. elegans nematodes have the ability to socially interact and to communicate through exchange and sensing of small soluble signaling compounds that help them cope with complex environmental conditions. For the time being, worm biocommu ...

Royal Soc Chemistry2016

Size-dependent sorting of C. elegans nematodes through an adjustable microfluidic filter structure

Thomas Lehnert, Martinus Gijs, Matteo Cornaglia, Li Dong

We introduce a new and simple microfluidic sorting device based on adjustable filter structures that can be easily tuned by external pressure for a specific size-dependent C. elegans worm sorting experiment. A single device can be used for selecting and so ...

2016

Versatile size-dependent sorting of C-elegans nematodes and embryos using a tunable microfluidic filter structure

Thomas Lehnert, Martinus Gijs, Matteo Cornaglia, Li Dong

The roundworm Caenorhabditis elegans (C. elegans) is a powerful model organism for addressing fundamental biological questions related to human disease and aging. Its life cycle consists of an embryo stage, four larval stages that can be clearly distinguis ...

Royal Soc Chemistry2016

Determination of sub-diffraction-limited organelles and biomolecules using microsphere lenses in combination with fluorescence microscopy

Martinus Gijs, Johan Auwerx, Norman Lionel Moullan, Hui Yang

We propose the use of a high-refractive index glass microsphere in combination with a conventional fluorescence microscope for imaging sub-cellular organelles and biomolecules. The microsphere is placed on a sample that is immersed in water, collects the n ...

Spie-Int Soc Optical Engineering2015

Digital microfluidics for time-resolved cytotoxicity studies on single non-adherent yeast cells

Martinus Gijs, Matteo Cornaglia

Single cell analysis (SCA) has gained increased popularity for elucidating cellular heterogeneity at genomic, proteomic and cellular levels. Flow cytometry is considered as one of the most widely used techniques to characterize single cell responses; howev ...

Royal Soc Chemistry2015

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

Thomas Lehnert, Martinus Gijs, Johan Auwerx, Shreya Narasimhan, Matteo Cornaglia, Laurent Mouchiroud, Alexis Pierre Henri Marette, Virginija Jovaisaite

Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, as well as of parallelization providing a population's statistics, while keepin ...

Nature Publishing Group2015

Separation of magnetic microparticles in segmented flow using asymmetric splitting regimes

Martinus Gijs, Matteo Cornaglia

A magnetic microparticle-based bioassay requires the separation of the microparticles from the sample matrix, after the microparticles have specifically captured the target of interest. For the implementation of such an assay in water-in-oil droplet segmen ...

Springer Heidelberg2015

Dose-response curve of a microfluidic magnetic bead-based surface coverage sandwich assay

Thomas Lehnert, Martinus Gijs, Hüseyin Cumhur Tekin, Matteo Cornaglia, Raphaël Etienne Jean Trouillon

Magnetic micro-and nanoparticles ('magnetic beads') have been used to advantage in many microfluidic devices for sensitive antigen (Ag) detection. Today, assays that use as read-out of the signal the number count of immobilized beads on a surface for quant ...

Elsevier2015

Inflammatory and metabolic responses to high-fat meals with and without dairy products in men

Martinus Gijs, Guy Vergères

Postprandial inflammation is an important factor for human health since chronic low-grade inflammation is associated with chronic diseases. Dairy products have a weak but significant anti-inflammatory effect on postprandial inflammation. The objective of t ...

Cambridge University Press2015

Photonic Nanojet Array for Fast Detection of Single Nanoparticles in a Flow

Martinus Gijs, Hui Yang, Matteo Cornaglia

We detect by optical microscopy Au and fluorescent nanopartides (NPs) during their motion in water based medium, using an array of dielectric microspheres that are patterned in a microwell array template. The Microspheres act as lenses focusing the light o ...

American Chemical Society2015

Interplay between the potential waveform and diffusion layer dynamics determines the time-response of voltammetric detection in microchannels

Martinus Gijs, Raphaël Etienne Jean Trouillon

The diffusion layer is a critical factor affecting the temporal response of electrochemical devices. In this article, we have investigated the effect of the relaxation of the diffusion layer during the potentiodynamic sensing of ferrocenemethanol (FcMeOH) ...

Elsevier2015

Nanocalorimetric platform for accurate thermochemical studies in microliter volumes

Thomas Lehnert, Martinus Gijs, Rima Padovani, Raphaël Etienne Jean Trouillon

A straightforward and general way for monitoring chemical reactions is via their thermal signature. Such approach requires however an experimental setup with a high thermal stability that simultaneously allows time-resolved heat detection with high sensiti ...

Royal Soc Chemistry2015

Study of constrained Brownian motion of nanoparticles near an interface using optical tweezers

Thomas Lehnert, Martinus Gijs, Hui Yang, Matteo Cornaglia, Raphaël Etienne Jean Trouillon

We demonstrate a method to determine the Brownian motion and the diffusion coefficient of a nanoparticle in water in a plane that is parallel to a solid boundary and as function of the distance normal to that boundary by using an optical tweezers instrumen ...

Spie-Int Soc Optical Engineering2015

Optical microscopy using a glass microsphere for metrology of sub-wavelength nanostructures

Martinus Gijs, Hui Yang

A technique that allows direct optical imaging of nanostructures and determines quantitatively geometric nanofeatures beyond the classical diffraction limit by using high-refractive index glass microspheres is introduced. The glass microsphere is put on a ...

Elsevier2015

Spherical superstructures of oxide nanoparticles for catalytic reactions in microchemical reactors

Martinus Gijs, Virendra Kumar Parashar, Josias Basil Wacker

We report the fabrication of spherical superstructures composed of SiO2 and TiO2 nanoparticles and their applications in catalyzing organic reactions. Assembling of the nanoparticles into superstructures is done by heating a water-in-oil micro-emulsion, wh ...

Elsevier Science Bv2015

A random-walk based model to explain ultrasensitive magnetic bead-based immunoassays

Thomas Lehnert, Martinus Gijs, Hüseyin Cumhur Tekin, Matteo Cornaglia, Raphaël Etienne Jean Trouillon

We introduce a new modeling approach for understanding the fundamental principle of bead-based surface coverage immunoassays that rely on the specific interaction between surface-bound “small” magnetic beads (1 μm in diameter) and a flow of “large” magneti ...

2014

Cathodic pretreatment improves the resistance of boron-doped diamond electrodes to dopamine fouling

Martinus Gijs, Raphaël Etienne Jean Trouillon

The resistance of cathodically and anodically treated boron-doped diamond electrodes to dopamine fouling was investigated. It was found, using cyclic voltammetry and electrochemical impedance spectroscopy, that the cathodic preparation offers an increased ...

Elsevier2014

Magnetic Particle-Scanning for Ultrasensitive Immunodetection On-Chip

Thomas Lehnert, Martinus Gijs, Hüseyin Cumhur Tekin, Matteo Cornaglia, Raphaël Etienne Jean Trouillon

We describe the concept of magnetic particle-scanning for on-chip detection of biomolecules: a magnetic particle, carrying a low number of antigens (Ag's) (down to a single molecule), is transported by hydrodynamic forces and is subjected to successive sto ...

American Chemical Society2014

A microfluidic process for on-chip formation of assemblies of oxide nanoparticles

Martinus Gijs, Virendra Kumar Parashar, Josias Basil Wacker, Danut Necula

We report the continuous growth of spherical assemblies of silica and titania nanoparticles, which were pre-activated to produce hydroxyl/ peroxy groups on their surface, by flowing a colloid-in-dioctyl phthalate emulsion into a polydimethylsiloxane microf ...

Royal Soc Chemistry2014

Magnetic microparticle based DNA extraction in a droplet microfluidic chip

Martinus Gijs, Matteo Cornaglia

2014

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