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Claudio Bruschini

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Publications associées (180)

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GigaRad total ionizing dose and post-irradiation effects on 28 nm bulk MOSFETs

Christian Enz, Claudio Bruschini, Farzan Jazaeri, Chunmin Zhang, Alessandro Pezzotta

The DC performance of both n- and pMOSFETs fabricated in a commercial-grade 28 nm bulk CMOS process has been studied up to 1 Grad of total ionizing dose and at post-irradiation annealing. The aim is to assess the potential use of such an advanced CMOS tech ...

IEEE2016

LinoSPAD: a time-resolved 256x1 CMOS SPAD line sensor system featuring 64 FPGA-based TDC channels running at up to 8.5 giga-events per second

Edoardo Charbon, Claudio Bruschini, Samuel Burri

LinoSPAD is a reconfigurable camera sensor with a 256x 1 CMOS SPAD (single-photon avalanche diode) pixel array connected to a low cost Xilinx Spartan 6 FPGA. The LinoSPAD sensor's line of pixels has a pitch of 24 pm and 40% fill factor. The FPGA implements ...

Spie-Int Soc Optical Engineering2016

Single-Photon, Time-Gated, Phasor-Based Fluorescence Lifetime Imaging through Highly Scattering Medium

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

Fluorescence lifetime imaging (FLI) is increasingly recognized as a powerful tool for biochemical and cellular investigations, including in vivo applications. Fluorescence lifetime is an intrinsic characteristic of any fluorescent dye which, to a large ext ...

AMER CHEMICAL SOC2020

Theoretical minimum uncertainty of single-molecule localizations using a single-photon avalanche diode array

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Paul Mos

Single-photon avalanche diode (SPAD) arrays can be used for single-molecule localization microscopy (SMLM) because of their high frame rate and lack of readout noise. SPAD arrays have a binary frame output, which means photon arrivals should be described a ...

OPTICAL SOC AMER2021

Ghost imaging using two SPAD array detectors: a parameter study towards the realization of a 3D quantum microscope

Edoardo Charbon, Claudio Bruschini, Paul Mos, Yang Lin

Quantum ghost imaging can be an important tool in making optical measurements. One of the most useful aspects of ghost imaging is the unique ability to correlate two sets of independently collected information. We aim to use the principles of ghost imaging ...

Spie-Int Soc Optical Engineering2024

Impact of GigaRad Ionizing Dose on 28 nm bulk MOSFETs for future HL-LHC

Christian Enz, Claudio Bruschini, Farzan Jazaeri, Chunmin Zhang, Alessandro Pezzotta

The Large Hadron Collider (LHC) running at CERN will soon be upgraded to increase its luminosity giving rise to radiations reaching the level of GigaRad Total Ionizing Dose (TID). This paper investigates the impact of such high radiation on transistors fab ...

IEEE2016

Wide-field fluorescence lifetime imaging of single molecules with a gated single-photon camera

Edoardo Charbon, Claudio Bruschini, Aleksandra Radenovic, Matteo Dal Peraro, Nathan Cyprien Arsène Ronceray, Marianna Fanouria Mitsioni

Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool to discriminate fluorescent molecules or probe their nanoscale environment. Traditionally, FLIM uses time-correlated single-photon counting (TCSPC), which is precise but intrinsically low-t ...

2025

LinoSPAD: A Compact Linear SPAD Camera System with 64 FPGA-Based TDC Modules for Versatile 50 ps Resolution Time-Resolved Imaging

Edoardo Charbon, Claudio Bruschini, Samuel Burri

The LinoSPAD camera system is a modular, compact and versatile time-resolved camera system, combining a linear 256 high fill factor pixel CMOS SPAD (single-photon avalanche diode) sensor with an FPGA (field-programmable gate array) and USB 3.0 transceiver ...

2017

Fluorescence lifetime imaging using a single photon avalanche diode array sensor

Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic, Samuel Burri

Single photon detectors allows us work with the weakest fluorescence signals. Single photon arrays, combined with ps-controlled gating allow us to create image maps of fluorescence lifetimes, which can be used for in-vivo discrimination of tissue activity. ...

2017

A 73% Peak PDP Single-Photon Avalanche Diode Implemented in 110 nm CIS Technology With Doping Compensation

Edoardo Charbon, Claudio Bruschini, Myung Jae Lee, Ekin Kizilkan, Utku Karaca

In this article, we present 10 mu m diameter SPADs fabricated in 110 nm CIS technology based on an N (+) /HVPW junction, with enhanced sensitivity at short wavelengths. To reduce tunneling noise due to the highly-doped layers in the process, a doping compe ...

Ieee-Inst Electrical Electronics Engineers Inc2024

Towards Surface-Correction of Deep-Tissue Blood Flow Dynamics with Massively Parallelized Diffuse Correlation Spectroscopy

Edoardo Charbon, Claudio Bruschini, Michael Alan Wayne

Diffuse Correlation Spectroscopy (DCS) allows the optical and label-free investigation of microvascular dynamics. Commonly, DCS is implemented with highly sensitive and ultra fast single-photon avalanche diodes (SPAD) for blood flow measurements from aroun ...

SPIE2024

SPAD imagers in fluorescence-guided surgical navigation

Edoardo Charbon, Claudio Bruschini

Fluorescence surgical navigation helps surgeons to see molecular information about tissue near the surface and distinguish malignancies from healthy tissue. It is possible to label tumors with specific fluorescent molecules, but not to easily see into tiss ...

SPIE2023

Large reconfigurable quantum circuits with SPAD arrays and multimode fibers

Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic

Reprogrammable integrated optics provides a natural platform for tunable quantum photonic circuits, but faces challenges when high dimensions and high connectivity are involved. Here, we implement high-dimensional linear transformations on spatial modes of ...

Optica Publishing Group2024

Imaging free and bound NADH towards cancer tissue detection using FLIM system based on SPAD array

Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic, Samuel Burri

Summary form only given. Single photon detectors allow us to work with the weakest signals such as auto-fluorescent biological sources. In combination with time gated operation mode, an array of detectors can be used as Fluorescence Lifetime Imaging system ...

2017

Piccolo gated: a CMOS 32×32 SPAD camera with all-solid-state nanosecond time gating and PCIe readout for single-photon time-domain DCS and near-infrared optical tomography

Edoardo Charbon, Claudio Bruschini, Scott Anthony Lindner, Paul Mos, Michael Alan Wayne, Tommaso Milanese

The Piccolo gated sensor features a 32x32 SPAD array of single-photon avalanche diodes (SPADs) operating in time-correlated single-photon counting (TCSPC). The chip enables event-driven readout and a maximum count rate of 220 Mcps. The sensor is based on t ...

SPIE2024

A Low-noise CMOS SPAD Pixel with 12.1 ps SPTR and 3 ns Dead Time

Edoardo Charbon, Claudio Bruschini, Francesco Gramuglia, Myung Jae Lee, Ming-Lo Wu

In this paper, we present the first CMOS SPAD with performance comparable or better than that of the best custom SPADs, to date. The SPAD-based design, fully integrated in 180 nm CMOS technology, achieves a peak PDP of 55% at 480nm with a very broad spectr ...

2022

SPADnet: a fully digital, scalable and networked photonic component for time-of-flight PET applications

Edoardo Charbon, Claudio Bruschini

The SPADnet FP7 European project is aimed at a new generation of fully digital, scalable and networked photonic components to enable large area image sensors, with primary target gamma-ray and coincidence detection in (Time-of-Flight) Positron Emission Tom ...

Spie-Int Soc Optical Engineering2014

Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Michael Alan Wayne

Significance: Diffuse correlation spectroscopy (DCS) allows label-free, non-invasive investigation of microvascular dynamics deep within tissue, such as cerebral blood flow (CBF). However, the signal-to-noise ratio (SNR) in DCS limits its effective cerebra ...

SPIE-Intl Soc Optical Eng2025

Phasor-based widefield FLIM using a gated 512×512 single-photon SPAD imager

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Ivan Michel Antolovic

Single-photon avalanche diode (SPAD) imagers can perform fast time-resolved imaging in a compact form factor, by exploiting the processing capability and speed of integrated CMOS electronics. Developments in SPAD imagers have recently made them compatible ...

2019

On-chip artificial neural network for PET source position reconstruction

Edoardo Charbon, Claudio Bruschini, Emanuele Ripiccini

This work presents the characterization results and methods used to determine the reconstruction of a 22Na point source placed in a coincidence setup. For this purpose, a novel, fully-integrated, reconfigurable feed-forward artificial neural network was im ...

IEEE2023