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Matthias Lütolf

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Publications associées (180)

Method and device for mixing two streams of droplets

Matthias Lütolf, Yoji Tabata, Andrea Negro

The invention relates to a method for mixing a first stream of droplets (1) with at least one second stream of droplets (2) to obtain a third stream of fused droplets (3), by collision and fusion of at least one droplet of the first stream (1) with at leas ...

2016

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Matthias Lütolf, Ruedi Aebersold, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies, Karim Laurent Gariani, Xu Wang, Peiling Luan, Davide D'Amico

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its imp ...

American Association for the Advancement of Science2016

Methods & compounds useful in hematopoietic stem cell medicine

Matthias Lütolf, Nicola Vannini, Johan Auwerx, Mukul Girotra, Olaia Maria Naveiras Torres-Quiroga

The present invention relates to a specific marker for stem cells having long-term multi-lineage blood reconstitution capability and uses thereof for the preparation of cell composition in view of hematopoietic stem cell medicine and in particular regenera ...

2016

Devices for high-throughput aggregation and manipulation of mammalian cells

Matthias Lütolf, Nathalie Brandenberg, Sylke Höhnel

The invention concerns a device (1) for aggregating cells comprising at least one cavity (2), wherein said cavity comprises a plurality of microwells (3) for receiving at least one cell, wherein each said well comprises a vertical sidewall and a curved bot ...

2016

Defined three-dimensional microenvironments boost induction of pluripotency

Matthias Lütolf, Yoji Tabata, Adrian Ranga, Yuya Okawa, Alessandra Piersigilli, Massimiliano Caiazzo

Since the discovery of induced pluripotent stem cells (iPSCs), numerous approaches have been explored to improve the original protocol, which is based on a two-dimensional (2D) cell-culture system. Surprisingly, nothing is known about the effect of a more ...

Nature Publishing Group2016

Substrate elasticity modulates the responsiveness of mesenchymal stem cells to commitment cues

Matthias Lütolf, Samy Gobaa

Fate choices of stem cells are regulated in response to a complex array of biochemical and physical signals from their microenvironmental niche. Whereas the molecular composition and the role of mechanical niche cues have been extensively studied, relative ...

Royal Soc Chemistry2015

Cell-Instructive Microgels with Tailor-Made Physicochemical Properties

Matthias Lütolf, Samantha Zerbib, Simone Allazetta, Laura Kolb

A microfluidic in vitro cell encapsulation platform to systematically test the effects of microenvironmental parameters on cell fate in 3D is developed. Multiple cell types including fibroblasts, embryonic stem cells, and cancer cells are incorporated in e ...

Wiley-V C H Verlag Gmbh2015

Stem cell niche engineering through droplet microfluidics

Matthias Lütolf, Simone Allazetta

Stem cells reside in complex niches in which their behaviour is tightly regulated by various biochemical and biophysical signals. In order to unveil some of the crucial stem cell-niche interactions and expedite the implementation of stem cells in clinical ...

Current Biology Ltd2015

Ultra-rapid prototyping of flexible, multi-layered microfluidic devices via razor writing

Matthias Lütolf, Steffen Cosson, Nathalie Brandenberg

The fabrication of microfluidic devices is often still a time-consuming and costly process. Here we introduce a very simple and cheap microfabrication process based on "razor writing", also termed xurography, for the ultra-rapid prototyping of microfluidic ...

Royal Soc Chemistry2015

Brief Report: Single-Cell Analysis Reveals Cell Division-Independent Emergence of Megakaryocytes From Phenotypic Hematopoietic Stem Cells

Matthias Lütolf, Aline Roch, Vincent Trachsel

Despite increasingly stringent methods to isolate hematopoietic stem cells (HSCs), considerable heterogeneity remains in terms of their long-term self-renewal and differentiation potential. Recently, the existence of long-lived, self-renewing, myeloid-rest ...

Wiley-Blackwell2015

Capturing Cell-Cell Interactions via SNAP-tag and CLIP-tag Technology

Matthias Lütolf

Juxtacrine or contact-dependent signaling is a major form of cell communication in multicellular organisms. The involved cell-cell and cell-extracellular-matrix (ECM) interactions are crucial for the organization and maintenance of tissue architecture and ...

Amer Chemical Soc2015

Locally controlling mesenchymal stem cell morphogenesis by 3D PDGF-BB gradients towards the establishment of an in vitro perivascular niche

Matthias Lütolf, Vincent Milleret, Yannick Robert Devaud, Philipp Sebastian Lienemann, Martin Ehrbar

The perivascular niche is a complex microenvironment containing mesenchymal stem cells (MSCs), among other perivascular cells, as well as temporally organized biochemical and biophysical gradients. Due to a lack of conclusive phenotypic markers, MSCs' iden ...

Royal Soc Chemistry2015

Hydrogel microfluidics for the patterning of pluripotent stem cells

Matthias Lütolf, Steffen Cosson

Biomolecular signaling is of utmost importance in governing many biological processes such as the patterning of the developing embryo where biomolecules regulate key cell-fate decisions. In vivo, these factors are presented in a spatiotemporally tightly co ...

Nature Publishing Group2014

Deciphering extrinsic regulation of stem cell differentiation in 3D

Matthias Lütolf

Wiley-Blackwell2014

A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells

Patrick Aebischer, Matthias Lütolf, Bernard Schneider, Steffen Cosson, Aurélien Lathuilière

The rapid increase in the number of approved therapeutic proteins, including recombinant antibodies, for diseases necessitating chronic treatments raises the question of the overall costs imposed on healthcare systems. It is therefore important to investig ...

Elsevier2014

3D niche microarrays for systems-level analyses of cell fate

Matthias Lütolf, Katarzyna Mosiewicz, Adrian Ranga, Samy Gobaa, Andrea Negro, Yuya Okawa

The behaviour of mammalian cells in a tissue is governed by the three-dimensional (3D) microenvironment and involves a dynamic interplay between biochemical and mechanical signals provided by the extracellular matrix (ECM), cell–cell interactions and solub ...

Nature Publishing Group2014

Mitochondrial Activity Determines Hematopoietic Stem Cell Fate Decisions

Matthias Lütolf, Aline Roch, Nicola Vannini, Johan Auwerx, Mukul Girotra, Olaia Maria Naveiras Torres-Quiroga, Vasco Ledebur de Antas de Campos

Amer Soc Hematology2014

Stem cell-materials interactions

Matthias Lütolf

Royal Soc Chemistry2014

Engineering synthetic stem cell niches

Matthias Lütolf

Elsevier Science Bv2014

3D Reconstitution of the Patterned Neural Tube from Embryonic Stem Cells

Matthias Lütolf, Adrian Ranga

Inducing organogenesis in 3D culture is an important aspect of stem cell research. Anterior neural structures have been produced from large embryonic stem cell (ESC) aggregates, but the steps involved in patterning such complex structures have been ill def ...

Cell Press2014

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