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Matthias Lütolf

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Publications associées (180)

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

Matthias Lütolf, Denis Duboule, Leonardo Beccari, Mehmet Ugur Girgin, Anne-Catherine Cossy, Alfonso Martinez Arias

The emergence of multiple axes is an essential element in the establishment of the mammalian body plan. This process takes place shortly after implantation of the embryo within the uterus and relies on the activity of gene regulatory networks that coordina ...

NATURE PUBLISHING GROUP2018

Microfluidic production of bioactive fibrin micro-beads embedded in crosslinked collagen used as an injectable bulking agent for urinary incontinence treatment

Matthias Lütolf, Jeffrey Alan Hubbell, Peter Frey, Hans Mattias Larsson, Simone Allazetta, Elif Vardar, Kalitha Pinnagoda, Ganesh Vythilingam

2018

Towards high throughput drug screening for human retina organoids

Roland Moser, Matthias Lütolf, Nathalie Brandenberg

MARY ANN LIEBERT, INC2018

3D-derivation of uncommitted human muscle stem cells from iPSCs

Matthias Lütolf, Filippo De Franceschi, Omid Mashinchian

MARY ANN LIEBERT, INC2018

The NAD plus Salvage Pathway Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance and Asymmetric Division

Matthias Lütolf, Yannick Lionel Yersin, Bart Deplancke, Nicola Vannini, Carlos Canto Alvarez, Martin Ehrbar, Mukul Girotra, Aurélien Laurent Jean-Charles Oggier, Dongryeol Ryu, Eija Riitta Pirinen, Olaia Maria Naveiras Torres-Quiroga, Pernille Yde Rainer, Gennady Nikitin, Vasco Ledebur de Antas de Campos, Joanna Ratajczak, Loïc Tauzin, Josefine Catharina Pedersen Tratwal, Federico Sizzano, George Coukos, Sonja Giger, Shanti Rojas-Sutterlin, Yang Li, Simone Ragusa

AMER SOC HEMATOLOGY2018

Label-Free Quantification Proteomics for the Identification of Mesenchymal Stromal Cell Matrisome Inside 3D Poly(Ethylene Glycol) Hydrogels

Matthias Lütolf, Yannick Robert Devaud, Martin Ehrbar

Cells modulate the functional properties of their environment by depositing extracellular matrix (ECM) proteins during biological processes in vivo and in vitro. Despite the ECMs central role in tissue formation, its quantification in hydrogels like Matrig ...

WILEY2018

Progress and potential in organoid research

Matthias Lütolf, Andrea Manfrin, Giuliana Rossi

Tissue and organ biology are very challenging to study in mammals, and progress can be hindered, particularly in humans, by sample accessibility and ethical concerns. However, advances in stem cell culture have made it possible to derive in vitro 3D tissue ...

2018

Organoid tissue engineering

Matthias Lütolf, Yoji Tabata, Nathalie Brandenberg, Nikolche Gjorevski, Mikhail Nikolaev

The invention relates to methods for developing and maintaining organoids and the organoids produced thereby. ...

2018

3D Inkjet Printing of Complex, Cell-Laden Hydrogel Structures

Matthias Lütolf, Andrea Negro, Thibaud Cherbuin

Inkjet printing is widely considered a promising strategy to pattern hydrogels and living cells into three-dimensional (3D) constructs that structurally resemble tissues in our body. However, this approach is currently constrained by the limited control ov ...

Nature Research2018

Artificial niche microarrays for identifying extrinsic cell-fate determinants

Matthias Lütolf, Samy Gobaa

The complex cellular microenvironment plays an important role in determining cell fate. For example, stem cells located in a microenvironment termed niche integrate a wide variety of extrinsic cues to take distinct fate choices. Capturing this multiple-inp ...

ELSEVIER ACADEMIC PRESS INC2018

Organoid arrays

Matthias Lütolf, Nathalie Brandenberg

The invention provides methods for producing arrays of organoids, the arrays thereof and uses of such arrays. ...

2018

Editorial overview: Tissue, cell and pathway engineering: The advent of complexity

Matthias Lütolf

Current Biology Ltd2017

Three dimensional hydrogels for culturing organoids

Matthias Lütolf, Nikolche Gjorevski

The invention provides hydrogels and methods for three-dimensional (3D) culture of adult epithelial stem cells and uses thereof. ...

2017

Natural polymer-derived scaffold material and methods for production thereof

Matthias Lütolf, Jeffrey Alan Hubbell, Peter Frey, Eva-Maria Balet, Hans Mattias Larsson, Simone Allazetta, Elif Vardar, Kalitha Pinnagoda

The invention relates to a scaffold material comprising a carrier and embedded microbeads for use in tissue engineering applications such as soft tissues therapeutic treatment. The scaffold provides a short-term bulking effect coupled with a long-term func ...

2017

The hope and the hype of organoid research

Matthias Lütolf, Alfonso Martinez Arias

The recent increase in organoid research has been met with great enthusiasm, as well as expectation, from the scientific community and the public alike. There is no doubt that this technology opens up a world of possibilities for scientific discovery in de ...

Company of Biologists2017

Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction

Matthias Lütolf, Yann Barrandon, Freddy Radtke, Craig Nowell, Sylke Höhnel, Georg Fantner, Pascal Damian Odermatt, Luca Azzolin

Chronic inflammation is associated with a variety of pathological conditions in epithelial tissues, including cancer, metaplasia and aberrant wound healing. In relation to this, a significant body of evidence suggests that aberration of epithelial stem and ...

Nature Publishing Group2016

Arrays of discrete cell culture microenvironments, methods of making such arrays and uses thereof

Matthias Lütolf, Adrian Ranga

The invention pertains to a combinatorial method of identifying the hydrogel formulations controlling phenotype and fate of difficult-to-culture cell types. ...

2016

A method for building a structure containing living cells

Matthias Lütolf, Andrea Negro

A composition comprising a first material and a second material, wherein said first material is cross-linkable by a first cross- linking reaction and said second material is cross-linkable by a second cross-linking reaction, wherein said first cross-linkin ...

2016

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

Matthias Lütolf, Aline Roch, Nicola Vannini, Johan Auwerx, Mukul Girotra, Olaia Maria Naveiras Torres-Quiroga, Gennady Nikitin, Vasco Ledebur de Antas de Campos, Sonja Giger

Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy production. However, whether this change in the metabolic program is the cause ...

Nature Publishing Group2016

3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling

Matthias Lütolf

Hydrogels have been used extensively in bioengineering as artificial cell culture supports. Investigation of the interrelationship between cellular response to the hydrogel and its chemistry ideally requires methods that allow characterization without labe ...

Amer Inst Physics2016

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