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Georges Wagnières

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Publications associées (166)

The Neovessel Occlusion Efficacy of 15(1)-hydroxypurpurin-7-lactone dimethyl ester induced with photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska, Siang Hui Lim

In this study, the photodynamic therapy (PDT) induced efficacy of a semi-synthesized analogue 151-hydroxypurpurin-7-lactone dimethyl ester or G2, in terms of chick chorioallantoic membrane blood vessel occlusion was evaluated in reference to verteporfin. E ...

Wiley-Blackwell2010

Angiostasis-induced vascular normalization can improve photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

Birkhäuser-Verlag, Springer2010

Processing of fluorescence angiograms for the quantification of vascular effects induced by anti-angiogenic agents in the CAM model

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

The chicken embryo chorioallantoic membrane (CAM) is widely used as an in vivo model to study the vascular effects of angiogenesis modulating agents. The main goal of the present study was to develop and validate a quantitative method to characterize time- ...

Elsevier2010

Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints

Georges Wagnières, Jutta Christine Wandrey, Jérôme Barge, Lucienne Lagopoulos, Frédéric Schmitt

Macrophages play key roles in inflammatory disorders. Therefore, they are targets of treatments aiming at their local destruction in inflammation sites. However, injection of low molecular mass therapeutics, including photosensitizers, in inflamed joints r ...

Elsevier2010

Errata: Processing of Fluorescence Angiograms for the Quantification of Vascular Effects Induced by Anti-angiogenic Agents in the CAM model (vol 79, pg 21, 2010)

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

Elsevier2010

In vitro and in vivo photocytotoxicity of boron dipyrromethene derivatives for photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska, Siang Hui Lim

To understand the effects of substitution patterns on photosensitizing the ability of boron dipyrromethene (BODIPY), two structural variations that either investigate the effectiveness of various iodinated derivatives to maximize the "heavy atom effect" or ...

American Chemical Society2010

Pioneers in biomedical optics: Special section honoring professor Tayyaba Hasan

Georges Wagnières

SPIE Society of Photo-optical Instrumentation Engineers2010

High-magnification vascular imaging to reject false-positive sites in situ during Hexvix® fluorescence cystoscopy

Hubert van den Bergh, Georges Wagnières, Blaise Lovisa

Fluorescence imaging for detection of non-muscle-invasive bladder cancer is based on the selective production and accumulation of fluorescing porphyrins-mainly, protoporphyrin IX-in cancerous tissues after the instillation of Hexvix (R). Although the sensi ...

SPIE Society of Photo-optical Instrumentation Engineers2010

In vitro and in vivo studies of new photoluminescent oxygen sensors for non-invasive intravascular pO 2 measurements

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

The concentration of oxygen and its rate of consumption are important factors playing a role in PDT and radiotherapy. One of the methods for measuring the tissular oxygen partial pressure (pO 2) is based on the use of luminophores presenting an oxygen-depe ...

2009

Autofluorescence bronchoscopy: quantification of inter-patient variations of fluorescence intensity

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht, Blaise Lovisa

Autofluorescence (AF) from bronchial tissue is increasingly used for the endoscopic detection of early bronchial neoplasia. Several imaging systems are commercially available, all detecting the absolute or relative AF intensity and/or spectral contrasts be ...

Springer-Verlag2009

In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence

Georges Wagnières, Pascal Uehlinger, Tanja Gabrecht

Time-resolved measurements of tissue autofluorescence (AF) excited at 405 nm were carried out with an optical-fiber-based spectrometer in the bronchi of 11 patients. The objectives consisted of assessing the lifetime as a new tumor/normal (T/N) tissue cont ...

SPIE Society of Photo-optical Instrumentation Engineers2009

Assessment of a sheep animal model to optimize photodynamic therapy with Foscan in the esophague

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, François André Borle

Precursor lesions of oesophagus adenocarcinoma constitute a clinical dilemma. Photodynamic therapy (PDT) is an effective treatment for this indication, but it is difficult to optimise without an appropriate animal model. For this reason, we assessed the sh ...

Wiley-Blackwell2009

Glycoside esters of 5-aminolevulinic acid for photodynamic therapy of cancer

Georges Wagnières, Jérôme Barge, Frédéric Schmitt

Aliphatic and ethylene glycol esters of 5-aminolevulinic acid (ALA) are very efficient precursors of the photosensitizer protoporphyrin IX (PpIX) for photodynamic therapy; however, they diffuse passively across the cell membrane and thus lack cell selectiv ...

American Chemical Society2008

Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tanja Gabrecht

Photodynamic therapy (PDT) based on the use of photoactivable porphyrins, such as protoporphyrin IX (PpIX), induced by the topical application of amino-levulinic acid (ALA) or its derivatives, ALA methyl-ester (m-ALA), is a treatment for superficial basal ...

Elsevier2008

Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfin (Visudyne(r)), in the CAM model

Hubert van den Bergh, Georges Wagnières, Elodie Debefve

The aim of the present study was to monitor photodynamic angioocclusion with verteporfin in capillaries. Details of this process were recorded under a microscope in real-time using a high-sensitivity video camera. A procedure was developed based on intrave ...

Springer Netherlands2008

Autofluorescence detection of tumors in the human lung - spectroscopical measurements in situ, in an in vivo model and in vitro

Georges Wagnières, Tanja Gabrecht

To detect bronchial carcinoma by autofluorescence, we measured the spectra of tumor and normal tissue in situ, in an in vivo model and in vitro by fiber optic spectrometer and two-dimensional resolved microspectroscopy. The in situ measurements were perfor ...

Elsevier2008

Improvement of the specificity of cancer detection by autofluorescence imaging in the tracheo-bronchial tree using backscattered violet light

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht

Autofluorescence bronchoscopy (AFB) is a highly sensitive tool for the detection of early bronchial cancers. However, its specificity remains limited due to primarily false positive results induced by hyperplasia, metaplasia and inflammation. We have inves ...

Elsevier2008

Fluorescence cystoscopy: Perspective in clinical practice and research

Hubert van den Bergh, Georges Wagnières, Blaise Lovisa

Many studies confirm the clinical interest of photodynamic diagnostics (PDD) in non-muscle invasive bladder cancer management. PDD or fluorescence cystoscopy is not only of great value in occult urothelial cancer detection, but may have a positive impact o ...

Springer Verlag2008

Improvement of the Contrast in Cancer Detection by Autofluorescence Bronchoscopy using a narrow spectral violet Excitation: A preliminary study

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht, Blaise Lovisa

Autofluorescence (AF) bronchoscopy is a useful tool for early cancer detection. However, the mechanisms involved in this diagnosis procedure are poorly understood. We present a clinical autofluorescence imaging study to assess the depth of the principal co ...

2007

Design of an endoscopic optical reference to be used for autofluorescence bronchoscopy with a commercially available diagnostic autofluorescence endoscopy (DAFE) system

Georges Wagnières, Tanja Gabrecht, François André Borle, Blaise Lovisa

We present the design of a sterilizable optical reference to characterize and quantify the inter-patient variations in tissue autofluorescence during autofluorescence bronchoscopy with Richard Wolf's diagnostic autofluorescence endoscopy (DAFE) system. The ...

Institute of Physics2007

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