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Georges Wagnières

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Related publications (165)

Page 4 of 9

Increase and homogenization of the endogenous production of protoporphyrin IX by photobiomodulation

Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli

Photodynamic therapy (PDT) and/or photodetection (PDD) based on protoporphyrin IX (PpIX) are used in many medical fields. However, the endogenous production of PpIX in tissues after administration of its precursor, 5-aminolevulinic acid (ALA) or derivative ...

SPIE-INT SOC OPTICAL ENGINEERING2019

In vivo measurement of tissue oxygenation by time-resolved luminescence spectroscopy: advantageous properties of dichlorotris(1, 10-phenanthroline)-ruthenium(II) hydrate

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska, Matthieu Philippe Emmanuel Zellweger, Veronika Huntosova, Sandrine Gay

Measuring tissue oxygenation in vivo is of interest in fundamental biological as well as medical applications. One minimally invasive approach to assess the oxygen partial pressure in tissue (pO(2)) is to measure the oxygen-dependent luminescence lifetime ...

SPIE Society of Photo-optical Instrumentation Engineers2014

Porphyrin metalla-assemblies coupled to cellulose nanocrystals for PDT and imaging applications

Georges Wagnières

Photodynamic therapy (PDT) is an interesting and promising approach to tackle a broad spectrum of cancer. With the combination of a photosensitizer, light and oxygen, PDT achieves a unique selectivity by the production of localized reactive oxygen species ...

WORLD SCIENTIFIC PUBL CO PTE LTD2023

Antibody-fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice

Hubert van den Bergh, Georges Wagnières

To improve the detectability of tumors by light-induced fluorescence, the use of monoclonal antibodies (MoAb) as carriers of fluorescent molecules was studied. As a model for this approach, the biodistribution of an anticarcinoembryonic antigen (CEA) MoAb ...

1991

Production of the free radicals O-2(.-) and OH by irradiation of the photosensitizer zinc(II) phthalocyanine

Hubert van den Bergh, Georges Wagnières

Zinc(II) phthalocyanine (ZnPC) is a new photosensitizer currently undergoing phase I and II clinical trials at Lausanne's CHUV hospital for the photodynamic therapy (PDT) of early cancer in the upper aerodigestive tract. Activated oxygen species other than ...

1997

Blue-violet excited autofluorescence spectroscopy and imaging of normal and cancerous human bronchial tissue after formalin fixation

Georges Wagnières, Tanja Gabrecht

Autofluorescence (AF) imaging is a powerful tool for the detection of (pre-)neoplastic lesions in the bronchi. Several endoscopic imaging systems exploit the spectral and intensity contrast of AF between healthy and (pre-)neoplastic bronchial tissues, yet, ...

Wiley-Blackwell2007

Hypericin can cross barriers in the chicken's chorioallantoic membrane model when delivered in low-density lipoproteins

Georges Wagnières, Veronika Huntosova

Background: Low-density lipoproteins (LDL) were used as a natural drug delivery system for the transport of hypericin (Hyp) in the bloodstream of the chicken's chorioallantoic membrane model (CAM). Hyp was chosen as a model for hydrophobic drug used in pho ...

ELSEVIER SCIENCE BV2018

High-magnification vascular imaging to reject false-positive sites in situ during Hexvix® fluorescence cystoscopy

Hubert van den Bergh, Georges Wagnières, Blaise Lovisa

Fluorescence imaging for detection of non-muscle-invasive bladder cancer is based on the selective production and accumulation of fluorescing porphyrins-mainly, protoporphyrin IX-in cancerous tissues after the instillation of Hexvix (R). Although the sensi ...

SPIE Society of Photo-optical Instrumentation Engineers2010

In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence

Georges Wagnières, Tanja Gabrecht, Pascal Uehlinger

Time-resolved measurements of tissue autofluorescence (AF) excited at 405 nm were carried out with an optical-fiber-based spectrometer in the bronchi of 11 patients. The objectives consisted of assessing the lifetime as a new tumor/normal (T/N) tissue cont ...

SPIE Society of Photo-optical Instrumentation Engineers2009

In vivo measurement of the tissue oxygenation by time-resolved luminescence spectroscopy of protoporphyrin IX: Strategies to minimize artefacts associated with photoproducts

Georges Wagnières, Veronika Huntosova, Emmanuel Louis Arthur Gerelli

The determination of the oxygen partial pressure (pO(2)) in real time in living biological tissues is of high interest for numerous therapeutics, including photodynamic therapy (PDT) and radiotherapy. The minimally invasive and real-time measurement of the ...

Spie-Int Soc Optical Engineering2017

Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease

Hubert van den Bergh, Georges Wagnières, Hilal Lashuel, Blaise Lovisa, Abid Oueslati

Converging lines of evidence indicate that near-infrared light treatment, also known as photobiomodulation (PBM), may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human pathologies, including n ...

Public Library of Science2015

Pharmacokinetics and pharmacodynamics of tetra(m-hydroxyphenyl)chlorin in the hamster cheek pouch tumor model: comparison with clinical measurements

Hubert van den Bergh, Georges Wagnières

The pharmacokinetics (PK) of the photosensitizer tetra(m-hydroxyphenyl)chlorin (mTHPC) was measured by optical fiber-based light-induced fluorescence spectroscopy (LIFS) in the normal and tumoral cheek pouch mucosa of 29 Golden Syrian hamsters with chem. i ...

Elsevier2000

Spectroscopic studies of photobleaching and photoproduct formation of meta(tetrahydroxyphenyl)chlorin (m-THPC) used in photodynamic therapy. The production of singlet oxygen by m-THPC

Hubert van den Bergh, Georges Wagnières

Meta(tetrahydroxyphenyl)chlorin (m-THPC) is a new photosensitizer currently undergoing clin. trials at Lausanne's CHUV hospital for photodynamic therapy (PDT) of early cancer in the upper aerodigestive tract. The illumination of m-THPC with light at 650 nm ...

Elsevier1998

Catechin reduces phototoxic effects induced by protoporphyrin IX-based photodynamic therapy in the chick embryo chorioallantoic membrane

Georges Wagnières, Jaroslava Joniová

Significance: Side effects of many cancer treatments are associated with the production of reactive oxygen species (ROS) in normal tissues. This explains why patients treated by photodynamic therapy (PDT) often suffer from skin photosensitization, whereas ...

SPIE Society of Photo-optical Instrumentation Engineers2020

Photodynamic Therapy for Cancer of the Upper Aerodigestive Tract Using Tetra(m-hydroxyphenyl)chlorin

Hubert van den Bergh, Georges Wagnières

A major step in the development of photodynamic therapy (PDT) is the clinical optimization and evaluation of new photosensitizers (PS). Ideally, new compounds should be more effective and/or induce fewer side effects than the first generation PS such as he ...

1996

Understanding delayed fluorescence and triplet decays of Protoporphyrin IX under hypoxic conditions

Georges Wagnières

Photosensitizers of singlet oxygen exhibit three main types of reverse intersystem-crossing (RISC): thermally activated, triplet-triplet annihilation, and singlet oxygen feedback. RISC can be followed by delayed fluorescence (DF) emission, which can provid ...

SPRINGERNATURE2021

Effect of PpIX photoproducts formation on pO2 measurement by time-resolved delayed fluorescence spectroscopy of PpIX in solution and in vivo

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Emmanuel Louis Arthur Gerelli, Veronika Huntosova

The measurement of Protoporphyrin IX delayed fluorescence lifetime is a minimally invasive method for monitoring the levels of oxygen in cells and tissues. The excitation of Protoporphyrin IX during this measurement can lead to the formation of photoproduc ...

Elsevier Science Sa2016

5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Pascal Uehlinger

Protoporphyrin IX (PpIX) is used as a fluorescence marker and photosensitizing agent in photodynamic therapy (PDT). A temporary increase of PpIX in tissues can be obtained by administration of 5-aminolevulinic acid (ALA). Lipophilicity is one of the key pa ...

2000

Time-resolved spectrofluorometer for clinical tissue characterization during endoscopy

Hubert van den Bergh, Georges Wagnières

Time-resolved fluorescence spectroscopy has the potential to provide more information for the detection of early cancer than continuous wave spectroscopy. A new optical fiber-based spectrofluorometer for time-resolved fluorescence spectroscopy of biol. tis ...

American Institute of Physics1999

Clinical evaluation of the cutaneous phototoxicity of 5, 10, 15, 20-tetra (m-hydroxyphenyl)chlorin

Hubert van den Bergh, Georges Wagnières

The cutaneous phototoxic reaction induced by i.v. injection of 5,-10,-15,-20-tetra(m-hydroxyphenyl)chlorin (mTHPC) has been clin. evaluated in patients undergoing photodynamic therapy. These tests were performed on the backs of 23 patients with a solar sim ...

1998