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Georges Wagnières

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Publications associées (165)

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Fluorescence cystoscopy: Perspective in clinical practice and research

Hubert van den Bergh, Georges Wagnières, Blaise Lovisa

Many studies confirm the clinical interest of photodynamic diagnostics (PDD) in non-muscle invasive bladder cancer management. PDD or fluorescence cystoscopy is not only of great value in occult urothelial cancer detection, but may have a positive impact o ...

Springer Verlag2008

Optimized autofluorescence bronchoscopy using additional backscattered red light

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht

Autofluorescence bronchoscopy (AFB) has been shown to be a highly sensitive tool for the detection of early endobronchial cancers. When excited with blue-violet light, early neoplasia in the bronchi tend to show a decrease of autofluorescence in the green ...

SPIE Society of Photo-optical Instrumentation Engineers2007

Real-time, in vivo measurement of tissular pO(2) through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska, Anna Maria Novello, Cédric Xavier Paulou

Tissular oxygen concentration plays a key role during photodynamic therapy (PDT). Therefore, monitoring its local oxygen partial pressure (pO(2)) may help predict and/or control the outcome of a PDT treatment. The first real-time, in vivo measurements of t ...

SPIE Society of Photo-optical Instrumentation Engineers2012

In vitro and in vivo studies of new photoluminescent oxygen sensors for non-invasive intravascular pO 2 measurements

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

The concentration of oxygen and its rate of consumption are important factors playing a role in PDT and radiotherapy. One of the methods for measuring the tissular oxygen partial pressure (pO 2) is based on the use of luminophores presenting an oxygen-depe ...

2009

Temperature and oxygen-concentration dependence of singlet oxygen production by RuPhen as induced by quasi-continuous excitation

Georges Wagnières, Veronika Huntosova

Advanced Search Home > Journals > Photochemical & Photobi... > Temperature and oxygen-... For Authors & Referees | For Librarians | For Members Journal cover: Photochemical & Photobiological Sciences Photochemical & Photobiological Sciences Issue 12, ...

2014

Photoprotective effect of catechin during ALA-PDT

Georges Wagnières, Jaroslava Joniová

The production of reactive oxygen species (ROS) in normal tissues is associated with side effects of many cancer treatments. This is, in particular, the case for the skin photosensitization experienced by certain patients subjected to PDT based on a system ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Glycoside esters of 5-aminolevulinic acid for photodynamic therapy of cancer

Georges Wagnières, Frédéric Schmitt

Aliphatic and ethylene glycol esters of 5-aminolevulinic acid (ALA) are very efficient precursors of the photosensitizer protoporphyrin IX (PpIX) for photodynamic therapy; however, they diffuse passively across the cell membrane and thus lack cell selectiv ...

American Chemical Society2008

Photodynamic therapy for 101 early cancers of the upper aerodigestive tract, the esophagus, and the bronchi: a single-institution experience

Hubert van den Bergh, Georges Wagnières

Cancer, when detected at an early stage, has a very good probability of being eradicated by surgery or radiotherapy. However, less aggressive treatments also tend to provide high rates of cure without the side effects of radical therapy. We report on the r ...

Hindawi Publishing Corporation1999

Measurements by fluorescence microscopy of the time-dependent distribution of meso-tetra-hydroxyphenylchlorin in healthy tissues and chemically induced ''early'' squamous cell carcinoma of the Syrian hamster cheek pouch

Hubert van den Bergh, Georges Wagnières

The influence of the time interval between dye administration and detection by fluorescence microscopy was assessed in "early" squamous cell carcinomas of the cheek pouch mucosa and different healthy tissues of the Syrian hamster. Following intracardiac ...

1996

Red and NIR light dosimetry in the human deep brain

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa

Photobiomodulation (PBM) appears promising to treat the hallmarks of Parkinson's Disease (PD) in cellular or animal models. We measured light propagation in different areas of PD-relevant deep brain tissue during transcranial, transsphenoidal illumination ...

Iop Publishing Ltd2015

Study of the influence of over-the-counter vitamin supplement intake on urine fluorescence to optimize cancer detection by fluorescence cystoscopy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Carla Martoccia

Fluorescence cystoscopy (FC) efficiently enhances the detection and improves the therapeutic management of early bladder cancer. During an FC, about 150 ml of water is needed to inflate the bladder. The water is quickly diluted by urine which can be fluore ...

SPIE Society of Photo-optical Instrumentation Engineers2015

Optical spectroscopy of the bladder washout fluid to optimize fluorescence cystoscopy with Hexvix

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Carla Martoccia

Fluorescence cystoscopy enhances detection of early bladder cancer. Water used to inflate the bladder during the procedure rapidly contains urine, which may contain fluorochromes. This frequently degrades fluorescence images. Samples of bladder washout flu ...

SPIE Society of Photo-optical Instrumentation Engineers2014

Improvement of the specificity of cancer detection by autofluorescence imaging in the tracheo-bronchial tree using backscattered violet light

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht

Autofluorescence bronchoscopy (AFB) is a highly sensitive tool for the detection of early bronchial cancers. However, its specificity remains limited due to primarily false positive results induced by hyperplasia, metaplasia and inflammation. We have inves ...

Elsevier2008

Photodynamic therapy of early squamous cell carcinoma with tetra(m-hydroxyphenyl)chlorin: optimal drug-light interval

Hubert van den Bergh, Georges Wagnières

The optimal drug-light interval for effective photodynamic therapy (PDT) of early squamous cell carcinomas was evaluated with tetra(m-hydroxyphenyl)chlorin (mTHPC) by means of two complementary modalities: irradiation tests and ex vivo fluorescence microsc ...

1997

Pharmacokinetics of tetra(m-hydroxyphenyl)chlorin in human plasma and individualized light dosimetry in photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

The pharmacokinetics of the photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (mTHPC) was investigated in the plasma of 20 patients by absorption and fluorescence spectroscopy. The temporal behavior was characterized by a rapid decrease in concn. du ...

1998

Localization of tetra(m-hydroxyphenyl)chlorin (Foscan) in human healthy tissues and squamous cell carcinomas of the upper aero-digestive tract, the esophagus and the bronchi: a fluorescence microscopy study

Hubert van den Bergh, Georges Wagnières

Fluorescence ...

2001

The Neovessel Occlusion Efficacy of 15(1)-hydroxypurpurin-7-lactone dimethyl ester induced with photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

In this study, the photodynamic therapy (PDT) induced efficacy of a semi-synthesized analogue 151-hydroxypurpurin-7-lactone dimethyl ester or G2, in terms of chick chorioallantoic membrane blood vessel occlusion was evaluated in reference to verteporfin. E ...

Wiley-Blackwell2010

Photodynamic endometrial ablation: Morphological study

Georges Wagnières

Background and Objectives Endometriumablation provides an alternative treatment modality to hysterectomy for dysfunctional uterine bleeding (DUB). Its feasibility was demonstrated in animal studies. The purpose of this study was the evaluation of histol ...

Wiley-Blackwell2003

Long circulating half-life and high tumor selectivity of the photosensitizer meta-tetrahydroxyphenylchlorin conjugated to polyethylene glycol in nude mice grafted with a human colon carcinoma

Hubert van den Bergh, Georges Wagnières

In a model of nude mice bearing a human colon carcinoma xenograft, the biodistribution and tumor localization of metatetrahydroxyphenylchlorin (m-THPC) coupled to polyethylene glycol (PEG) were compared with those of the free form of this photosensitizer u ...

1998

Photochimiothérapie et photodétection du cancer à l'aide de photosensibilisateurs ou de colorants fluorescents

Georges Wagnières

EPFL1992