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Hubert van den Bergh

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Publications associées (145)

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Photodynamic diagnosis of ovarian cancer using hexaminolaevulinate: a preclinical study

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht

2003

A feedback loop optimized vascular targeted drug combination for the treatment of cancer

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska, Andrea Brett Gasser

Springer2014

Clinical evaluation of a method for detecting superficial transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following topical application of 5-aminolevulinic acid: Preliminary results

Hubert van den Bergh, Georges Wagnières

BACKGROUND AND OBJECTIVE: In bladder cancer, conventional white light endoscopic examination of the bladder does not provide adequate information about the presence of "flat" urothelial lesions such as carcinoma in situ. In the present investigation, we ex ...

1997

The chemical mechanism generation programme CHEMATA-Part 2: Comparison of four chemical mechanisms for mesoscale calculation of atmospheric pollution

Hubert van den Bergh, Alain Clappier

Elsevier2005

Assessment of a sheep animal model to optimize photodynamic therapy with Foscan in the esophague

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, François André Borle

Precursor lesions of oesophagus adenocarcinoma constitute a clinical dilemma. Photodynamic therapy (PDT) is an effective treatment for this indication, but it is difficult to optimise without an appropriate animal model. For this reason, we assessed the sh ...

Wiley-Blackwell2009

Correlation between Protoporphyrin IX Fluorescence Intensity, Photobleaching, Pain and Clinical Outcome of Actinic Keratosis Treated by Photodynamic Therapy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Background: Photodynamic therapy (PDT) with Metvix® is a good therapeutic option to treat actinic keratosis, but it presents drawbacks (pain, lesion recurrences, heterogeneous outcome), emphasizing the possible need to individualize treatment. Objective: W ...

Karger2013

Clinical pharmacokinetic studies of tetra(meta-hydroxyphenyl)chlorin in squamous cell carcinoma by fluorescence spectroscopy at 2 wavelengths

Hubert van den Bergh, Georges Wagnières

To optimize photodynamic therapy (PDT) and photodetection of cancer with second-generation photosensitizers, knowledge of important variables such as the uptake of the dye and the dye contrast between normal and tumoral tissue after injection is necessary. ...

1995

Clinical value of fluorescence cystoscopy in the detection of superficial transitional cell carcinomas of the bladder

Hubert van den Bergh, Georges Wagnières

The prognosis of superficial bladder cancer in terms of local recurrence and transformation into invasive cancer is related to the multiplicity of tumor sites and the concomitant presence of "flat" tumours, such as dysplasia and carcinoma in situ. This stu ...

1997

Low dose endoluminal photodynamic therapy improves murine T cell-mediated colitis

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht, François André Borle, Dominique Velin

Background and study aims: Low dose photodynamic therapy (LDPDT) may modify the mucosal immune response and may thus provide a therapy for Crohn's disease. We evaluated the efficacy and safety of this technique in a murine T cell-mediated colitis model. ...

2011

Intra-Arterial Drug and Light Delivery for Photodynamic Therapy Using Visudyne (R): Implication for Atherosclerotic Plaque Treatment

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Photodynamic therapy (PDT), which is based on the activation of photosensitizers with light, can be used to reduce plaque burden. We hypothesized that intra-arterial photosensitizer administration and photo-activation will lead to high and rapid accumulati ...

2016

Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

We have investigated the pharmacokinetics (PK) of Lutetium Texaphyrin (Lu-Tex), a second-generation photosensitizer, in the Syrian hamster cheek pouch early cancer model. Ten male hamsters, five with chem. induced early squamous cell cancer of the left che ...

Elsevier2000

Evaluation of the photosensitizer Tookad (R) for photodynamic therapy on the Syrian golden hamster cheek pouch model: Light dose, drug dose and drug-light interval effects

Hubert van den Bergh, Georges Wagnières, François André Borle

2003

Hexyl-aminolevulinate-mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach

Hubert van den Bergh

Photodynamic therapy (PDT) of superficial bladder cancer may cause damages to the normal surrounding bladder wall. Prevention of these is important for bladder healing. We studied the influence of photosensitizer concentration, irradiation parameters, and ...

Wiley-Blackwell2007

Optimizing light dosimetry in photodynamic therapy of the bronchi by fluorescence spectroscopy

Hubert van den Bergh, Georges Wagnières

1996

Investigation of two-layered turbid media with time-resolved reflectance

Hubert van den Bergh, Georges Wagnières

Light propagation in 2-layered turbid media that have an infinitely thick 2nd layer is studied with time-resolved reflectance. The authors used a soln. of the diffusion equation for this geometry to show that it is possible to derive the absorption and the ...

1998

Clinical pharmacokinetic studies of Photofrin II by fluorescence spectroscopy

Hubert van den Bergh, Georges Wagnières

Elsevier Science Publishers B.V.1992

Uptake and localisation of mTHPC (Foscan (R)) and its C-14-labelled form in normal and tumour tissues of the hamster squamous cell carcinoma model: a comparative study

Hubert van den Bergh, Georges Wagnières

2002

Clinical determination of tissue optical properties by endoscopic spatially resolved reflectometry

Hubert van den Bergh, Georges Wagnières

1996

Combination of low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy in human carcinoma models: lack of vascular normalization

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska, Andrea Brett Gasser, Débora Bonvin

Springer2014

Photoeradication of Helicobacter pylori in humans: Phase 1 study

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

1999