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Hubert van den Bergh

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Publications associées (145)

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A Raman lidar to measure water vapor in the atmospheric boundary layer

Hubert van den Bergh, Marc Parlange, Eric Richard Pardyjak, Valentin Simeonov, Chad Higgins, Martin Froidevaux

A new multi-telescope scanning Raman lidar designed to measure the water vapor mixing ratio in the atmospheric boundary layer for a complete diurnal cycle with high resolution spatial (1.25 m) and temporal (1 s) resolutions is presented. The high resolutio ...

Elsevier2013

Pharmacokinetics of tetra(m-hydroxyphenyl)chlorin in human plasma and individualized light dosimetry in photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

The pharmacokinetics of the photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (mTHPC) was investigated in the plasma of 20 patients by absorption and fluorescence spectroscopy. The temporal behavior was characterized by a rapid decrease in concn. du ...

1998

Localization of tetra(m-hydroxyphenyl)chlorin (Foscan) in human healthy tissues and squamous cell carcinomas of the upper aero-digestive tract, the esophagus and the bronchi: a fluorescence microscopy study

Hubert van den Bergh, Georges Wagnières

Fluorescence ...

2001

The Neovessel Occlusion Efficacy of 15(1)-hydroxypurpurin-7-lactone dimethyl ester induced with photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

In this study, the photodynamic therapy (PDT) induced efficacy of a semi-synthesized analogue 151-hydroxypurpurin-7-lactone dimethyl ester or G2, in terms of chick chorioallantoic membrane blood vessel occlusion was evaluated in reference to verteporfin. E ...

Wiley-Blackwell2010

Long circulating half-life and high tumor selectivity of the photosensitizer meta-tetrahydroxyphenylchlorin conjugated to polyethylene glycol in nude mice grafted with a human colon carcinoma

Hubert van den Bergh, Georges Wagnières

In a model of nude mice bearing a human colon carcinoma xenograft, the biodistribution and tumor localization of metatetrahydroxyphenylchlorin (m-THPC) coupled to polyethylene glycol (PEG) were compared with those of the free form of this photosensitizer u ...

1998

A new drug-screening procedure for photosensitizing agents used in photodynamic therapy for CNV

Hubert van den Bergh, Georges Wagnières

Because vascular occlusion has been observed as a consequence of photodynamic therapy (PDT), this method has been successfully used for the treatment of choroidal neovascularization (CNV) in age-related macular degeneration (AMD). However, most conventiona ...

2001

Solution for diagnosing or treating tissue pathology

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

PROBLEM TO BE SOLVED: To provide a composition for diagnosing and/or treating cancerous pathologies in the field of urology. ;SOLUTION: The invention relates to a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation usefu ...

1999

Photodynamic therapy for polypoidal choroidal vasculopathy

Hubert van den Bergh, Patrycja Nowak-Sliwinska

The first effective therapy for exudative macular degeneration (AMD) was Photodynamic Therapy (PDT). Diagnosis of the disease was to a large extent by fluorescein angiography (FA). Distinguishing between the leaky choroidal neovessels (CNV) associated with ...

Pergamon-Elsevier Science Ltd2013

Synthesis and characterization of a new class of anti-angiogenic agent based on ruthenium clusters

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl, Mathurin Baquié

New triruthenium-carbonyl clusters derivatized with glucose-modified bicyclophosphite ligands have been synthesized. These compounds were found to have cytostatic and cytotoxic activity and depending on the number of bicyclophosphite ligands, and could be ...

Nature Publishing Group2013

Three-dimensional optical phantom and its application in photodynamic therapy

Hubert van den Bergh, Georges Wagnières

BACKGROUND AND OBJECTIVE: A technique to manufacture a stable, reproducible three-dimensional optical phantom is presented. This phantom reproduces the tissue's optical properties as well as the geometry and, to some extent, the mechanical properties of th ...

1997

Autofluorescence bronchoscopy: quantification of inter-patient variations of fluorescence intensity

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht, Blaise Lovisa

Autofluorescence (AF) from bronchial tissue is increasingly used for the endoscopic detection of early bronchial neoplasia. Several imaging systems are commercially available, all detecting the absolute or relative AF intensity and/or spectral contrasts be ...

Springer-Verlag2009

Improvement of the Contrast in Cancer Detection by Autofluorescence Bronchoscopy using a narrow spectral violet Excitation: A preliminary study

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht, Blaise Lovisa

Autofluorescence (AF) bronchoscopy is a useful tool for early cancer detection. However, the mechanisms involved in this diagnosis procedure are poorly understood. We present a clinical autofluorescence imaging study to assess the depth of the principal co ...

2007

Optimization of the diameter of a radial irradiation device for photodynamic therapy in the esophagus

Hubert van den Bergh, Georges Wagnières, Thomas Stepinac

2002

Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tanja Gabrecht

Photodynamic therapy (PDT) based on the use of photoactivable porphyrins, such as protoporphyrin IX (PpIX), induced by the topical application of amino-levulinic acid (ALA) or its derivatives, ALA methyl-ester (m-ALA), is a treatment for superficial basal ...

Elsevier2008

Line-of-sight data transmission system based on Mid IR quantum cascade laser

Hubert van den Bergh, Valentin Simeonov

We report on an application of a pulsed distributed feedback quantum cascade laser (QCL) for an open path data transmission. A pulse QCL in the 1046 cm(-1) range (28.7 THz) is used as a carrier signal source. The QCL is modulated with 50 ns pulses at repet ...

Spie-Int Soc Optical Engineering, Po Box 10, Bellingham, Wa 98227-0010 Usa2008

Correlations between photoactivable porphyrins’ fluorescence, erythema and the pain induced by PDT on normal skin using ALA-derivatives

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Summary Background Photodynamic therapy (PDT) with precursors of photoactivable porphyrins is a well-established treatment modality for skin pathologies as well as hair removal. Pain is a major side effect thereof, and it affects the treatment compliance a ...

Elsevier2013

Endoscopic fluorescence detection of intraepithelial neoplasia in Barrett's esophagus after oral administration of aminolevulinic acid

Hubert van den Bergh, Georges Wagnières, Thomas Stepinac, Tanja Gabrecht

2003

An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

1997

Drug Combination for Treatment of Proliferative Diseases

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska

Angiogenesis inhibitory drug combination obtained according to a specific algorithm, preferably a FSC, in which an initial combination of drugs is iteratively adjusted. The drug combination according to the invention may advantageously comprise a RAPTA-C c ...

2017

Clinical assessment of fluorescence cystoscopy during transurethral bladder resection in superficial bladder cancer

Hubert van den Bergh, Georges Wagnières

The prognosis of superficial bladder cancer in terms of recurrence and disease progression is related to bladder tumor multiplicity and the presence of concomitant "plane" tumors such as high-grade dysplasia and carcinoma in situ. This study in 33 patients ...

1997