Home

Person

Heinrich Hofmann

About
Privacy
Disclaimer

Graph Chatbot

Related publications (121)

Protein Corona: Impact of Lymph Versus Blood in a Complex In Vitro Environment

Heinrich Hofmann, Ulrich Aschauer, Marc Moniatte, Diego Chiappe, Marijana Mionic Ebersold, Duncan Thomas Lindsay Alexander, Débora Bonvin

In biological environments, the surface of nanoparticles (NPs) are modified by protein corona (PC) that determines their biological behavior. Unfortunately, in vitro tests still give different PC than in vivo tests causing in vitro-in vivo discrepancy; hen ...

Wiley-Blackwell2017

Transparent and Robust Silica Coatings with Dual Range Porosity for Enzyme-Based Optical Biosensing

Bernard Wenger, Heinrich Hofmann, Raphaël Pugin, Oswaldo Javier Pérez Anguiano, Emmanuel Scolan

Hierarchically porous transparent silica coatings combine large specific surface area with enhanced pore accessibility for optical biosensing. This paper describes a versatile approach to fabricate optically transparent silica coatings with multiscale poro ...

Wiley-Blackwell2017

Efficiency of SPIONs functionalized with polyethylene glycol bis (amine) for heavy metal removal

Heinrich Hofmann, Yongyuth Wanna

Hybrid magnetic nanoparticles based on poly(methylmethacrylate) (PMMA) and super-paramagnetic iron oxide nanopaticles (SPIONs) with selective surface modification has been developed for heavy metal removal by applying external magnetic fields. The nanopart ...

Elsevier2016

Engineered nanomaterials: toward effective safety management in research laboratories

Heinrich Hofmann, Thierry Meyer, Amela Groso, Alke Fink

Background: It is still unknown which types of nanomaterials and associated doses represent an actual danger to humans and environment. Meanwhile, there is consensus on applying the precautionary principle to these novel materials until more information is ...

BioMed Central2016

Continuous Synthesis of Gold Nanoparticles Using the Segmented Flow Tubular Reactor (SFTR)

Heinrich Hofmann, Andrea Testino, Agnese Carino, Aurélie Walter

Schweizerische Chemische Gesellschaft2016

Optimisation of aqueous synthesis of iron oxide nanoparticles for biomedical applications

Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin

Iron oxide nanoparticles (IONPs) were prepared via aqueous synthesis which combines alkaline co-precipitation (CP) of ferric and ferrous precursors with mild hydrothermal (HT) treatment without cupping agents (CA). In this novel synthesis route, CP + HT, w ...

Springer Verlag2016

Magnetic nanoparticle-induced hyperthermia with appropriate payloads: Paul Ehrlich's "magic (nano)bullet" for cancer theranostics?

Heinrich Hofmann, Swati Krishnan

Effective multimodal cancer management requires the optimal integration of diagnostic and therapeutic modalities. Radiation therapy, chemotherapy and immunotherapy, alone or in combination, are integral parts of various cancer treatment protocols. Hyperthe ...

Elsevier2016

New approach to low thermal conductivity of thermal barrier protection with improved mechanical integrity

Paul Bowen, Heinrich Hofmann, Abhishek Tewari

Layered ceramic systems with designed stacks of dense and porous layers were investigated as alternative for thermal barrier protection system (TBPs). This approach gives the possibility to obtain low thermal conductivity with the impact protection of dens ...

Elsevier2016

Modification of the surface of superparamagnetic iron oxide nanoparticles to enable their safe application in humans

Heinrich Hofmann, Lionel André Maurizi

Combined individually tailored methods for diagnosis and therapy (theragnostics) could be beneficial in destructive diseases, such as rheumatoid arthritis. Nanoparticles are promising candidates for theragnostics due to their excellent biocompatibility. Na ...

Dove Medical Press Ltd2016

Hydrophobization of silver nanoparticles through surface-initiated atom transfer radical polymerization

Heinrich Hofmann, Frank Nüesch, Jose Enrico Quijano Quinsaat

This work describes the synthesis of poly(methyl methacrylate) (PMMA)-coated Ag@SiO2 core-shell particles by conducting a Surface-Initiated Atom Transfer Radical Polymerization (SI-ATRP). Silver nanoparticles (AgNPs) were first prepared by the polyol synth ...

RSC Publishing2016

Nanostandardization in Action: Implementing Standardization Processes in a Multidisciplinary Nanoparticle-Based Research and Development Project

Heinrich Hofmann

Nanomaterials have attracted much interest in the medical field and related applications as their distinct properties in the nanorange enable new and improved diagnosis and therapies. Owing to these properties and their potential interactions with the huma ...

Springer2016

Effects of PVA-coated nanoparticles on human T helper cell activity

Heinrich Hofmann, Lionel André Maurizi

Superparamagnetic iron oxide nanoparticles (SPION) are used as high-sensitive enhancer for magnetic resonance imaging, where they represent a promising tool for early diagnosis of destructive diseases such as rheumatoid arthritis (RA). Since we could demon ...

Elsevier2016

Accumulation of amino-polyvinyl alcohol-coated superparamagnetic iron oxide nanoparticles in bone marrow: implications for local stromal cells

Heinrich Hofmann

First, it will be investigated if amino-polyvinyl alcohol-coated superparamagnetic iron oxide nanoparticles (A-PVA-SPIONs) are suitable for MRI contrast enhancement in bone marrow. Second, the impact of A-PVA-SPION exposure in vivo on the viability and key ...

Future Medicine2015

Effects of PVA coated nanoparticles on human immune cells

Heinrich Hofmann, Lionel André Maurizi

Nanotechnology provides new opportunities in human medicine, mainly for diagnostic and therapeutic purposes. The autoimmune disease rheumatoid arthritis (RA) is often diagnosed after irreversible joint structural damage has occurred. There is an urgent nee ...

Dove Medical Press Ltd2015

Analysis of Quantized Electrical Characteristics of Microscale TiO2 Ink-Jet Printed Memristor

Heinrich Hofmann, Marijana Mionic Ebersold, Goran Stojanovic

We demonstrate the ink-jet printed fabrication technique for TiO2-based memristor, followed by detailed analysis of electrical characteristics and development of a new model that considers observed phenomena of quantized conductance steps. The existence of ...

Institute of Electrical and Electronics Engineers2015

Polymer Adsorption on Iron Oxide Nanoparticles for One-Step Amino-Functionalized Silica Encapsulation

Heinrich Hofmann, Lionel André Maurizi

This paper presents an original method to obtain, in one step, core/shell nanoparticles grafted covalently with polymer and functionalized with amino groups. By combining polyvinyl alcohol (PVA) and silica precursors, we were able to obtain silica-coated a ...

Hindawi Publishing Corporation2015

Controlling Mesopore Size and Processability of Transparent Enzyme-Loaded Silica Films for Biosensing Applications

Bernard Wenger, Heinrich Hofmann, Raphaël Pugin, Oswaldo Javier Pérez Anguiano, Emmanuel Scolan

Silica-based nanoporous thin films including large mesopores are relevant as enzyme supports for applications in biosensing. The diffusion and immobilization of large biomolecules such as enzymes in such porous films require the presence of large mesopores ...

Amer Chemical Soc2015

Nanoparticles in medicine: Current challenges facing inorganic nanoparticle toxicity assessments and standardizations

Heinrich Hofmann

Although nanoparticles research is ongoing since more than 30 years, the development of methods and standard protocols required for their safety and efficacy testing for human use is still in development. The review covers questions on toxicity, safety, ri ...

Elsevier2015

Significance of surface charge and shell material of superparamagnetic iron oxide nanoparticle (SPION) based core/shell nanoparticles on the composition of the protein corona

Heinrich Hofmann, Géraldine Sylvie Coullerez, Morteza Mahmoudi, Usawadee Sakulkhu, Lionel André Maurizi

As nanoparticles (NPs) are increasingly used in many applications their safety and efficient applications in nanomedicine have become concerns. Protein coronas on nanomaterials' surfaces can influence how the cell "recognizes" nanoparticles, as well as the ...

Royal Soc Chemistry2015

Transfer studies of polystyrene nanoparticles in the ex vivo human placenta perfusion model: key sources of artifacts

Heinrich Hofmann, Lionel André Maurizi

Nanotechnology is a rapidly expanding and highly promising new technology with many different fields of application. Consequently, the investigation of engineered nanoparticles in biological systems is steadily increasing. Questions about the safety of suc ...

Elsevier2015

Page 2 of 7