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Dominique Pioletti

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Publications associées (190)

Chondrogenic modulation by thermogenesis

Dominique Pioletti, Arne Christian Vogel

Wiley-Blackwell2012

Damping properties of the nucleus pulposus

Dominique Pioletti, Arne Christian Vogel

Background: The nucleus pulposus is extremely deformable and it is not uncommon to observe strain amplitudes as large as 12.5% in physiological loading conditions. It has been shown that the nucleus pulposus contributes to the damping properties of the int ...

Elsevier2012

A new technique to measure micromotion distribution around a cementless femoral stem

Dominique Pioletti, Alexandre Terrier, Miguel Gortchacow

The interfacial micromotion is closely associated to the long-term success of cementless hip prostheses. Various techniques have been proposed to measure them, but only a few number of points over the stem surface can be measured simultaneously. In this pa ...

Elsevier2011

Cellular Gradient Polymer Composites

Dominique Pioletti, Pierre-Etienne Bourban, Matthieu Cuénoud

2011

Biodegradable Polymer Nanocomposite Scaffolds for Bone Replacement Paper

Dominique Pioletti, Pierre-Etienne Bourban, John Christopher Plummer, Claire Diane Delabarde

2011

Cellular biodegradable polymer nanocomposite scaffolds

Dominique Pioletti, Pierre-Etienne Bourban, John Christopher Plummer, Alireza Roshan Ghias, Claire Diane Delabarde

2011

Biodegradable Polymer Nanocomposite Scaffolds for Bone Replacement

Dominique Pioletti, Pierre-Etienne Bourban, John Christopher Plummer, Alireza Roshan Ghias, Claire Diane Delabarde

2011

In vivo loading increases mechanical properties of scaffold by affecting bone formation and bone resorption rates

Dominique Pioletti, Alireza Roshan Ghias

A successful bone tissue engineering strategy entails producing bone-scaffold construct with adequate mechanical properties. Apart from the mechanical properties of the scaffold itself, the forming bone inside the scaffold also adds to the strength of the ...

2011

Combined effects of zoledronate and mechanical stimulation on bone adaptation in an axially loaded mouse tibia

Dominique Pioletti, Vincent Stadelmann

Background: Local bisphosphonate delivery may be a solution to prevent periprosthetic bone loss and improve orthopedic implants fixation. In load-bearing implants, periprosthetic bone is exposed to high mechanical demands, which in normal conditions induce ...

Elsevier2011

Prediction of spatio-temporal bone formation in scaffold by diffusion equation

Dominique Pioletti, Lalaonirina Rakotomanana Ravelonarivo, Arne Christian Vogel, Alireza Roshan Ghias

Developing a successful bone tissue engineering strategy entails translation of experimental findings to clinical needs. A major leap forward towards this goal is developing a quantitative tool to predict spatial and temporal bone formation in scaffold. We ...

2011

In vivo assessment of local effects after application of bone screws delivering bisphosphonates into a compromised cancellous bone site

Dominique Pioletti, Alireza Roshan Ghias

Background: The primary stability of cancellous screw is difficult to obtain in bone of compromised quality and failure of screw fixation is common. To overcome this problem, it is proposed to locally deliver bisphosphonate from the screw An in vivo valida ...

Elsevier2011

Surgical preparation of bone-scaffold interface is critical for bone regeneration inside tissue engineering scaffold

Dominique Pioletti, Alireza Roshan Ghias

The goal of this study was to investigate if the preparation of implantation site has an impact on bone formation inside tissue engineering scaffolds. For this purpose, two different drilling techniques were used to create a hole in distal femurs of rats b ...

Wiley-Blackwell2011

Biologicals and fetal cell therapy for wound healing and scar management

Dominique Pioletti, Nathalie Hirt-Burri, Corinne Scaletta, Lee Ann Laurent-Applegate

Few biopharmaceutical preparations developed from biologicals are available for tissue regeneration and scar management. When developing biological treatments with cellular therapy, selection of cell types and establishment of consistent cell banks are cru ...

2011

Biomechanics and tissue engineering

Dominique Pioletti

Development of artificial scaffold for musculo-skeletal applications, especially in load-bearing situations, requires the consideration of biomechanical aspects for its integrity and its function. However, the biomechanical loading could also be used to fa ...

Springer Verlag2011

Human fetal bone cells in delivery systems for bone engineering

Dominique Pioletti, Sandra Jaccoud, Nathalie Hirt-Burri, Corinne Scaletta, Lee Ann Laurent-Applegate

The aim of this study was to culture human fetal bone cells (dedicated cell banks of fetal bone derived from 14 week gestation femurs) within both hyaluronic acid gel and collagen foam, to compare the biocompatibility of both matrices as potential delivery ...

Wiley-Blackwell2011

Bone regeneration and stem cells

Dominique Pioletti

This invited review covers research areas of central importance for orthopaedic and maxillofacial bone tissue repair, including normal fracture healing and healing problems, biomaterial scaffolds for tissue engineering, mesenchymal and foetal stem cells, e ...

2011

Regulation of proliferation and differentiation of human fetal bone cells

Dominique Pioletti, Lee Ann Laurent-Applegate

During the last decade, extensive research has been performed in the field of orthopedic medicine to develop cell-based therapies for the restoration of injured bone tissue. We previously demonstrated that human primary fetal bone cells (HFBCs) associated ...

2011

Biomechanics in bone tissue engineering

Dominique Pioletti

Biomechanics may be considered as central in the development of bone tissue engineering. The initial mechanical aspects are essential to the outcome of a functional tissue engineering approach, so are aspects of interface micromotion, bone ingrowths inside ...

Taylor & Francis2010

In vivo cyclic loading as a potent stimulatory signal for bone formation inside tissue engineering scaffolds

Dominique Pioletti, Pierre-Etienne Bourban, Alexandre Terrier, Alireza Roshan Ghias

In clinical situations, bone defects are often located at load bearing sites. Tissue engineering scaffolds are future bone substitutes and hence they will be subjected to mechanical stimulation. The goal of this study was to test if cyclic loading can be u ...

European Cells & Materials Ltd2010

Mechanical interaction between cells and fluid for bone tissue engineering scaffold: modulation of the interfacial shear stress

Dominique Pioletti, Alexandre Terrier, Lalaonirina Rakotomanana Ravelonarivo, Luc Blecha

An analytical model of the fluid/cell mechanical interaction was developed. The interfacial shear stress, due to the coupling between the fluid and the cell deformation, was characterized by a new dimensionless number . For above a critical value, the flui ...

2010

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