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Michael Amrhein

Cette personne a quitté l’EPFL

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Publications associées (26)

Page 1 sur 2

Automatic detection of reaction start/endpoints in chemical and biotechnological reaction systems

Michael Amrhein, Simon Crelier

A classification methodology for the automatic detection of start- and endpoints of chemical and biotechnological reaction systems from spectral reaction data is proposed. In the calibration phase, several batch experiments must be conducted covering the e ...

2007

On-Line Recalibration of Spectral Measurements Using Metabolite Injections and Dynamic Orthogonal Projection

Urs von Stockar, Michael Amrhein, Pamandeep Singh Gujral, Michal Dabros

Spectrometers are enjoying increasing popularity in bioprocess monitoring due to their non-invasiveness and in-situ sterilizability. Their on-line applicability and high measurement frequency create an interesting opportunity for process control and optimi ...

2007

On decoupling rate processes in chemical reaction systems - Methods and applications

Dominique Bonvin, Julien Léo Billeter, Michael Amrhein, Diogo Filipe Mateus Rodrigues

Models of chemical reaction systems can be complex as they need to include information regarding the reactions and the mass and heat transfers. The commonly used state variables, namely, concentrations and temperatures, express the interplay between many p ...

2018

Incremental Identification of Reaction and Mass-Transfer Kinetics Using the Concept of Extents

Dominique Bonvin, Michael Amrhein, Nirav Pravinbhai Bhatt

This paper proposes a variation of the incremental approach to identify reaction and mass-transfer kinetics (rate expressions and the corresponding rate parameters) from concentration measurements for both homogeneous and gas-liquid reaction systems. This ...

2011

Minimal State Representation for Open Fluid-Fluid Reaction Systems

Dominique Bonvin, Philippe Müllhaupt, Michael Amrhein, Nirav Pravinbhai Bhatt

Reaction systems are typically represented by first-principles models that describe the evolution of the states (typically concentrations, volume and temperature) by means of conservation equations of differential nature and constitutive equations of algeb ...

Ieee Computer Soc2012

Classification of magnetic resonance images from rabbit renal perfusion

Dominique Bonvin, Michael Amrhein, Pamandeep Singh Gujral

The feasibility of using chemometric techniques for the automatic detection of whether a rabbit kidney is pathological or not is studied. Sequential images of the kidney are acquired using Dynamic Contrast-Enhanced Magnetic Resonance Imaging with contrast ...

2009

Information extraction from the Evolving Factor Analysis

Simon Crelier, Michael Amrhein

The goal of our project (HES-SO n°11246) is to develop chemometric methods that enhance the development of chemical reactions. Semi-batch experiments are performed using a fully automated chemical reactor. Real-time analytical data, infrared (IR) spectra f ...

2005

Framework for explicit drift correction in multivariate calibration models

Dominique Bonvin, Michael Amrhein, Pamandeep Singh Gujral

Latent-variable calibrations using principal component regression and partial least-squares regression are often compromised by drift such as systematic disturbances and offsets. This paper presents a two-step framework that facilitates the evaluation and ...

2010

Identification of reaction and mass-transfer rates in gas-liquid reaction systems

Dominique Bonvin, Michael Amrhein, Nirav Pravinbhai Bhatt

This paper deals with the identification of reaction and mass-transfer rates from concentrations measured in gas-liquid reaction systems. It is assumed that the reactions take place in the liquid bulk only. The identification proceeds in two steps: (i) est ...

IIT-Madras2010

Incremental Identification of Reaction Systems - A Comparison between Rate-based and Extent-based Approaches

Dominique Bonvin, Michael Amrhein, Nirav Pravinbhai Bhatt

An incremental identification approach for determining the kinetics of homogeneous reaction systems from transient concentration measurements has been developed in previous work (Marquardt, W. Chemical Engineering Research and Design 83(A6), 561–573, 2005) ...

Elsevier2012

Extents of Reaction, Mass Transfer and Flow for Gas-Liquid Reaction Systems

Dominique Bonvin, Michael Amrhein, Nirav Pravinbhai Bhatt

For gas-liquid reaction systems with inlet and outlet streams, this paper proposes a linear transformation to decompose the numbers of moles vector into five distinct parts, namely, the extents of reaction, the extents of mass transfer, the extents of inle ...

2010

Scale-up of batch processes via decentralized control

Dominique Bonvin, Michael Amrhein, Benoît Chachuat, Alejandro Gabriel Marchetti

The economic environment in the specialty chemicals industry requires short times to market and thus the ability to develop new products and processes very rapidly. This, in turn, calls for large scale-ups from laboratory to production. Due to scale-relate ...

2006

Data Reconciliation of Concentration Estimates from Mid-Infrared and Dielectric Spectral Measurements for Improved On-Line Monitoring of Bioprocesses

Dominique Bonvin, Urs von Stockar, Ian William Marison, Michael Amrhein, Michal Dabros

Real-time data reconciliation of concentration estimates of process analytes and biomass in microbial fermentations is investigated. A Fourier-transform mid-infrared spectrometer predicting the concentrations of process metabolites is used in parallel with ...

2009

Measurement-Based Drift Correction in Spectroscopic Calibration Models

Dominique Bonvin, Michael Amrhein, Pamandeep Singh Gujral

Correct prediction of analyte concentrations from a new spectrum without drift is possible provided the spectrum lies in the row space spanned by the calibration spectra (space-inclusion condition). However, this condition may be violated as on-line spectr ...

cemagref Languedoc Roussillon2008

Partial least-squares regression with unlabeled data

Dominique Bonvin, Michael Amrhein, Pamandeep Singh Gujral

It is well known that the prediction errors from principal component regression (PCR) and partial least-squares regression (PLSR) can be reduced by using both labeled and unlabeled data for stabilizing the latent subspaces in the calibration step. An appro ...

2009

Drift Correction in Multivariate Calibration Models Using On-line Reference Measurements

Dominique Bonvin, Michael Amrhein, Pamandeep Singh Gujral

On-line measurements from first-order instruments such as spectrometers may be compromised by instrumental, process and operational drifts that are not seen during off-line calibration. This can render the calibration model unsuitable for prediction of key ...

2009

Fast Estimation of Plant Steady State, with Application to Static RTO

Dominique Bonvin, Michael Amrhein, Julien Léo Billeter, Diogo Filipe Mateus Rodrigues

Experimental assessment or prediction of plant steady state is important for many applications in the area of modeling and operation of continuous processes. For example, the iterative implementation of static real-time optimization requires reaching stead ...

2016

ALS Scheme using Extent-based Constraints for the Analysis of Chemical Reaction Systems

Dominique Bonvin, Michael Amrhein, Julien Léo Billeter

Multivariate curve resolution via alternating least squares (ALS) is used to resolve the concentration profiles C and the pure component spectra E of S species from the multivariate absorbance data A, assuming the bilinear model ...

2016

Robust gain-scheduled blending control of raw-mix quality in cement industries

Alireza Karimi, Michael Amrhein

This paper addresses the control of the blending process in cement industries. This process can be modeled by a nonlinear multivariable system with large parametric uncertainty. Using a specific transformation, a linear parameter varying (LPV) model with s ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2011

Concept and Applications of Extents in Chemical Reaction Systems

Dominique Bonvin, Michael Amrhein, Julien Léo Billeter, Sriniketh Srinivasan, Diogo Filipe Mateus Rodrigues

Models of chemical reaction systems can be quite complex as they typically include information regarding the reactions, the various transfers of heat and mass, as well as the effects of the inlet and outlet flows. It is well known that a linear transformat ...

2017