Jan Sickmann HesthavenProf. Hesthaven received an M.Sc. in computational physics from the Technical University of Denmark (DTU) in August 1991. During the studies, the last 6 months of 1989 was spend at JET, the european fusion laboratory in Culham, UK. Following graduation, he was awarded a 3 year fellowship to begin work towards a Ph.D. at Riso National Laboratory in the Department of Optics and Fluid Dynamics. During the 3 years of study, the academic year of 1993-1994 was spend in the Division of Applied Mathematics at Brown University and three 3 months during the summer of 1994 in Department of Mathematics and Statistics at University of New Mexico. In August 1995, he recieved a Ph.D. in Numerical Analysis from the Institute of Mathematical Modelling (DTU). Following graduation in August 1995, he was awarded an NSF Postdoctoral Fellowship in Advanced Scientific Computing and was approinted Visiting Assistant Professor in the Division of Applied Mathematics at Brown University. In December of 1996, he was appointed consultant to the Institute of Computer Applications in Science and Engineering(ICASE) at NASA Langley Research Center (NASA LaRC). As of July 1999, he was appointed Assistant Professor of Applied Mathematics, in September 2000 he was awarded an Alfred P. Sloan Fellowship, as of July 2001 he was awarded a Manning Assistant Professorship, and in March 2002, he was awarded an NSF Career Award. In January 2003, he was promoted to Associate Professor of Applied Mathematics with tenure and in May 2004 he was awarded Philip J. Bray Award for Excellence in Teaching in the Sciences (the highest award given for teaching excellence in all sciences at Brown University). He was promoted to Professor of Applied Mathematics as of July 2005. From October 2006 to June 2013, he was the Founding Director of the Center for Computation and Visualization (CCV) at Brown University. As of October 2007, he holds the (honorary) title of Professor (Adjunct) at the Technical University of Denmark. In November 2009, he successfully defended his dr.techn thesis at the Technical University of Denmark and was rewarded the degree of Doctor Technices -- the highest academic distinction awarded based on ... substantial and lasting contributions that has helped to move the research area forward and penetrated into applications. As grant Co-PI he served from Aug 2010 to June 2013 as Deputy Director of the Institute of Computational and Experimental Research in Mathematics (ICERM), the newest NSF Mathematical Sciences Research Institute. After having spend his entire academic career at Brown University, Prof Hesthaven decided to pursue new challenges and joined the Mathematics Institute of Computational Science and Engineering (MATHICSE) at Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland in July 2013. In March 2014 he was elected SIAM Fellow for contributions to high-order methods for partial differential equations.
Mathieu SalzmannI am a Senior Researcher at EPFL-CVLab, and, since May 2020, an Artificial Intelligence Engineer at ClearSpace (50%). Previously, I was a Senior Researcher and Research Leader in NICTA's computer vision research group. Prior to this, from Sept. 2010 to Jan 2012, I was a Research Assistant Professor at TTI-Chicago, and, from Feb. 2009 to Aug. 2010, a postdoctoral fellow at ICSI and EECS at UC Berkeley under the supervision of Prof. Trevor Darrell. I obtained my PhD in Jan. 2009 from EPFL under the supervision of Prof. Pascal Fua.
Jean-François MolinariProfessor J.F. Molinari is the director of the Computational Solid Mechanics Laboratory (http://lsms.epfl.ch) at EPFL, Switzerland. He holds an appointment in the Civil Engineering institute, which he directed from 2013 to 2017, and a joint appointment in the Materials Science institute. He started his tenure at EPFL in 2007, and was promoted to Full Professor in 2012. He is currently an elected member of the Research Council of the Swiss National Science Foundation in Division 2 (Mathematics, Natural and Engineering Sciences), and co editor in chief of the journal Mechanics of Materials. J.F. Molinari graduated from Caltech, USA, in 2001, with a M.S. and Ph.D. in Aeronautics. He held professorships in several countries besides Switzerland, including the United States with a position in Mechanical Engineering at the Johns Hopkins University (2000-2006), and France at Ecole Normale Supérieure Cachan in Mechanics (2005-2007), as well as a Teaching Associate position at the Ecole Polytechnique de Paris (2006-2009). The work conducted by Prof. Molinari and his collaborators takes place at the frontier between traditional disciplines and covers several length scales from atomistic to macroscopic scales. Over the years, Professor Molinari and his group have been developing novel multiscale approaches for a seamless coupling across scales. The activities of the laboratory span the domains of damage mechanics of materials and structures, nano- and microstructural mechanical properties, and tribology. Hans Peter HerzigDr. Hans Peter Herzig is Professor at the Ecole Polytechnique Fédérale de Lausanne (EPFL) and Past President of the European Optical Society (EOS). His current research interests include refractive and diffractive micro-optics, nano-scale optics and optical MEMS.
Hans Peter Herzig received his diploma in physics from the Swiss Federal Institute of Technology in Zürich, Switzerland, in 1978. From 1978 to 1982 he was a scientist with the Optics Development Department of Kern in Aarau, Switzerland, working in lens design and optical testing. In 1983, he became a graduate research assistant with the Applied Optics Group at the Institute of Microtechnology of the University of Neuchâtel, Switzerland, working in the field of holographic optical elements. In 1987, he received his PhD degree in optics. From 1989 to 2001 he was head of the micro-optics research group in Neuchâtel. From 2002 to 2008 he was a full professor and head of the Applied Optics Laboratory at the University of Neuchâtel. Professor Herzig joined the faculty at EPFL in January 2009.
He is member of OSA, IEEE Photonics Society and Fellow of EOS. 2009-2010 he was President of the European Optical Society (EOS), 2001-2009 Vice-President of the Swiss Society of Optics and Microscopy and 2012-2014 Vice-President of ICO. Dr. Herzig is in the editorial board of different scientific journals (JM3, Optical Review, JEOS). He served as Conference Chairman for international conferences of EOS, IEE, IEEE/LEOS, OSA and SPIE; and as Guest Editor of three special issues of IEEE, OSA journals. He is editor of a well-known book on micro-optics (published in English and Chinese), author of 14 book chapters, over 150 peer reviewed articles and 300 conference proceedings.
Michael Christoph GastparMichael Gastpar is a (full) Professor at EPFL. From 2003 to 2011, he was a professor at the University of California at Berkeley, earning his tenure in 2008. He received his Dipl. El.-Ing. degree from ETH Zürich, Switzerland, in 1997 and his MS degree from the University of Illinois at Urbana-Champaign, IL, USA, in 1999. He defended his doctoral thesis at EPFL on Santa Claus day, 2002. He was also a (full) Professor at Delft University of Technology, The Netherlands. His research interests are in network information theory and related coding and signal processing techniques, with applications to sensor networks and neuroscience. He is a Fellow of the IEEE. He is the co-recipient of the 2013 Communications Society & Information Theory Society Joint Paper Award. He was an Information Theory Society Distinguished Lecturer (2009-2011). He won an ERC Starting Grant in 2010, an Okawa Foundation Research Grant in 2008, an NSF CAREER award in 2004, and the 2002 EPFL Best Thesis Award. He has served as an Associate Editor for Shannon Theory for the IEEE Transactions on Information Theory (2008-11), and as Technical Program Committee Co-Chair for the 2010 International Symposium on Information Theory, Austin, TX.
Ambrogio FasoliAmbrogio FASOLI was born on November 10, 1964, in Milano, Italy. After a classical high school diploma (Maturità Classica) and graduation from the University of Milano, with the degree of Dottore in Fisica, he obtained his Phd at the Ecole Polytechnique Fédérale (EPFL) with a thesis on chaos in wave-particle interactions in plasmas, which was awarded the Best EPFL Thesis prize, in 1993. He then moved to the JET Joint Undertaking, the largest worlds fusion device, near Oxford, UK, to investigate Alfvén waves and burning plasma physics. In 1995-1996 he took a sabbatical leave, visiting several Universities and Research Institutes in Europe and in the USA, including three months at General Atomics in San Diego. In 1996-1997, during a second period at JET, he participated in the fusion power worlds record experiments in Deuterium-Tritium plasmas at JET. In 1997 he was nominated Assistant Professor in MIT Physics Department, where he led a basic plasma physics group and the international collaboration between MIT and JET. In 2001 Ambrogio FASOLI was nominated Assistant Professor of Physics at EPFL, Lausanne, Switzerland, and Professeur Boursier of the Swiss National Science Foundation. He became member of CRPP Directorate and took the leadership of CRPP basic plasma physics group and of the TCV tokamak, one of the major fusion experiments worldwide. At European level he was scientific coordinator for JET experiments, spokesperson for multi-machine experiments in the frame of International Tokamak Physics Activities, and Project Leader for a JET Enhancement project. In 2005 he became Associate Professor of Physics with tenure at EPFL, then member of EFDA Science and Technology Advisory Committee, and of the Steering Committee of the Association EURATOM-Swiss Confederation. From 2006 he was also Deputy Director, then from 2007 Executive Director of CRPP and from 2008 Full Professor of Physics at EPFL. For a number of years he was the Chair of the EPFL Physics Strategic Committee and a member of the Directorate of the EPFL School of Sciences. Since the summer of 2014 Professor FASOLI was the sole Director of CRPP. He now represents Switzerland in the EUROfusion General Assembly and Bureau, and in the Governing Board for Fusion for Energy. He is member of the EUROfusion DEMO project Board, of the Scientific Board of the Helmotz Virtual Institute on Advanced Microwave Diagnostics, of the European Delegation for the Cooperation between Euratom and the Government of India in Fusion Energy Research, of the European Consortium for the development of the ITER gyratron (EGYC), and participates to numerous international review panels. He chairs the FuseNet Academic Council, the International Advisory Panel for the Laboratory of Excellence Plas@Par in the Sorbonne Universities, the European Consortium for the construction of the ITER microwave Upper Launcher (ECHUL), and the Promotion Committee of the EPFL Faculty of Basic Sciences. He is one the three European representatives in the International Tokamak Physics Activities Coordinating Committee, advising ITER, and the Editor-in-Chief of the IAEA journal Nuclear Fusion. Since January 2019, Ambrogio Fasoli is the Chair of the General Assembly, i.e. the president of EUROfusion, the European Consortium for Development of Fusion Energy. Professor FASOLI is a Fellow of the American Physical Society and since 2001 a Visiting Professor at MIT Physics Department. He is the Director of the Swiss Plasma Center.
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
