Unit

Prof. Radtke Group

Laboratory

Summary

The Radtke Lab at EPFL, led by Prof. Radtke, focuses on understanding the molecular mechanisms that regulate stem cell maintenance, lineage commitment, and differentiation in self-renewing systems like the hematopoietic system, skin, and gut. They investigate how signaling pathways such as Shh, Wnt, and Notch control these processes and how their dysregulation can lead to tumorigenesis. Particularly, they study the Notch signaling pathway's roles in different self-renewing tissues and cancer, aiming to identify novel therapeutic targets and improve strategies for treating tumorigenesis.

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Prof. Radtke Group

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Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

Characterization of the gut-bone marrow axis through bile acid signaling

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics