Publications related to A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems

Related publications (10)

Gene-expression memory-based prediction of cell lineages from scRNA-seq datasets

Alexia Amandine Dormann, Almut Sophia Eisele, David Michael Suter

Assigning single cell transcriptomes to cellular lineage trees by lineage tracing has transformed our understanding of differentiation during development, regeneration, and disease. However, lineage tracing is technically demanding, often restricted in tim ...

Nature Portfolio2024

Bioengineered human colon organoids with in vivo-like cellular complexity and function

Nicolas Antoine Vincent Broguiere

Organoids and organs-on-a-chip have emerged as powerful tools for modeling human gut physiology and disease in vitro. Although physiologically relevant, these systems often lack the environmental milieu, spatial organization, cell type diversity, and matur ...

2024

Engineered progenitor cells and methods of use

Michele De Palma, Amaia Martinez Usatorre, Ali Ghasemi

Disclosed herein are engineered progenitor cells and methods of using the same. Also disclosed herein are engineered cells differentiated from engineered progenitor cells of the present disclosure. Also disclosed herein are methods of treating a condition ...

2023

Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion

Li Tang, George Coukos, Nicola Vannini, Marcela Rincón-Restrepo, Min Gao

Ho and colleagues report that mitochondrial dysfunction and impaired mitophagy triggered by the tumor microenvironment lead to subsequent epigenetic changes and cause permanent T cell exhaustion and dysfunction. The metabolic challenges present in tumors a ...

2020

Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Elisa Oricchio, Julien Racle, Sarah Wehrle, Elena Battistello, Jessica Sordet, Natalya Katanayeva, Stephanie Jocelyne Sungalee, Elie Charles Eugène Dheilly

Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We fou ...

2020

Successful Immunotherapy of Cancer Stem Cells Requires Memory and the Adaptive Immune System of the Host

Jörg Hülsken, Patrick Schmidt, Pierre Vincent Dessen, Nicolas Pierre Desbaillets

Nature Publishing Group2015

Temperature impacts human epidermal stem cell behaviour through thermoTRPs and mTOR signalling

Johannes Alexander Mosig

Adult stem cells are characterized by their unique ability to self-renew and give rise to a progeny of specialized/differentiated cells. Therefore, they have a remarkable potential for regenerative medicine. However, the use of adult stem cells is restrain ...

EPFL2013

RETRACTED: Marker-independent identification of glioma-initiating cells

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan

Tumor-initiating cells with stem cell properties are believed to sustain the growth of gliomas, but proposed markers such as CD133 cannot be used to identify these cells with sufficient specificity. We report an alternative isolation method purely based on ...

Nature Publishing Group2010

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Sandra Eloise Kjeldsen, Cyrille Dunant

Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns over every few weeks, suggesting that HSCs regularly enter and exit ...

2008

Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions

Patrick Aebischer, Bernard Schneider, Nicole Déglon

Allogeneic cells are the most attractive source for cell transplantation, as the use of xenogeneic cells is hampered by safety concerns and the use of autologous cells involves practical difficulties. The immune rejection of allogeneic cells can be overcom ...

2004