Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries

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We report the functionalization of cysteine residues with lipophilic alkynes bearing a silyl group or an alkyl chain using amphiphilic ethynylbenziodoxolone reagents (EBXs). The reactions were carried out in buffer (pH 6 to 9), without organic co-solvent o ...

Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries

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