Paolo De Los Rios

Mission The research activity of Paolo De Los Rios focuses on applications of statistical physics to biophysics and to the structure of complex networks. Understanding the physics of proteins is one of the great scientific challenges of the years to come. How do proteins fold to their functional form? How do they work once folded? How do they interact with each other? These and other questions are best approached by the interaction of biology, experimental biophysics and theoretical tools, with particular emphasis on statistical physics since thermal noise plays a determinant role at the scale of proteins. Many systems as different as the Internet and the World Wide Web, social interactions among individuals or market relations between companies, interacting proteins (see above) in the living cell, food web relations in habitats, and many others, find their unifying framework in the theory of complex networks. Although each network is a specific system with its own peculiarities, their large-scale properties can be studied with the tools of statistical physics so to discover that some general principles govern systems that are, at a first examination, very different and unrelated with each other. Paolo De Los Rios earned his master in Electronic Engineering at the Turin Institute of Technology (Politecnico di Torino) in May 1993. In November 1993 he moved to Trieste, Italy, to enter the PhD program in Theoretical Condensed Matter Theory at the International School for Advanced Studies (SISSA/ISAS) where he obtained the PhD degree in October 1996 for his work on the statistical physics of disordered systems. After a one year postdoc at the Max-Planck Institute for the Physics of Complex Systems in Dresden, Germany, in November 1997 he moved to the University of Fribourg, Switzerland, to join the group of Prof. Yi-Cheng Zhang. There he has worked on various applications of statistical physics to complex systems. In September 2000 he has been appointed Assistant Professor in Statistical Physics of Living Matter and Complex Systems at the Institute of Theoretical Physics of the University of Lausanne, Switzerland. Since April 2010 he is Associate Professor at the Institute of Theoretical Physics of the Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland. Teaching & PhD PhD Students María Li López Bautista, Subhasis Dehury, Lisa Gennai Past EPFL PhD Students Giovanni Salvi, Thomas Petermann, David Gfeller, Cécile Caretta Cartozo, David Morton de Lachapelle, Carlo Maffi, Lucio Floretta, Salvatore Assenza, Duccio Malinverni, Alberto Stefano Sassi, Andrea Martini, Solange Flatt, Adélaïde Alice Mohr, Shiling Liang, Alexandra Shelest, Davide Cois Past EPFL PhD Students as codirector Lorenzo Talamanca Courses EDCB seminar series BIOENG-606 The EDCB seminar series provides EDCB students the opportunity to share their research and learn from their peers. Students can freely exchange, present data, ideas and get useful feedback on ongoing research and improve communication skills. Statistical physics : theory of phase transitions PHYS-475 Phase transitions are ubiquitous, from the first instants of the universe to living matter. Despite the vast difference in microscopic details, some features of phase transitions are universal and can be explained by the careful use of statistical mechanics, leading up to the renormalisation group. Statistical physics of biomacromolecules PHYS-441 Biological macromolecules such as DNA, RNA, proteins and cytoskeletal filaments are polymers. As such, they share a set of properties that are common to any polymer, which are the focus of this course. Details about the protein folding problem will be covered in the last part.