Mammary epithelial morphogenesis in 3D combinatorial microenvironments

About
Privacy
Disclaimer

Graph Chatbot

Related publications (4)

Page 1 of 1

Boosting CAR T-cell therapy through G-protein signal rewiring

Liyan Yang Smeding

Chimeric antigen receptor (CAR) T-cell therapy continues to struggle in reaching its full potential in solid tumors, largely due to the tumor microenvironment (TME) where various small molecules induce immunosuppressive signaling in CAR T-cells. Two key mo ...

EPFL2024

tRNA-derived fragments in T lymphocyte-beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice

Christian Iseli, Nicolas Jean Philippe Guex

Aims/hypothesistRNAs play a central role in protein synthesis. Besides this canonical function, they were recently found to generate non-coding RNA fragments (tRFs) regulating different cellular activities. The aim of this study was to assess the involveme ...

SPRINGER2024

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Paolo De Los Rios, Bruno Lemaitre, Evelyne Ruchti, Sylvia Ho, Anthony Vocat, Marine Van Campenhoudt, Samuel Rommelaere, Greta Limoni, Stefano Zamuner, Giovanni D'Angelo, Laura Capolupo, Charlotte Julie Caroline Gehin, Samuel Sagar Kumar, Huixin Guo

Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesis, are ...

American Society for Clinical Investigation2023

Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure

Matthias Lütolf, Giuliana Rossi, Nicolas Antoine Vincent Broguiere

The specification of distinct cardiac lineages occurs before chamber formation and acquisition of bona fide atrial or ventricular identity. However, the mechanisms underlying these early specification events remain poorly understood. Here, we performed sin ...

COMPANY BIOLOGISTS LTD2022