Mammary epithelial morphogenesis in 3D combinatorial microenvironments

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Chimeric antigen receptor (CAR) T-cell therapy continues to struggle in reaching its full potential in solid tumors, largely due to the tumor microenvironment (TME) where various small molecules induce immunosuppressive signaling in CAR T-cells. Two key mo ...

Aims/hypothesistRNAs play a central role in protein synthesis. Besides this canonical function, they were recently found to generate non-coding RNA fragments (tRFs) regulating different cellular activities. The aim of this study was to assess the involveme ...

Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesis, are ...

The specification of distinct cardiac lineages occurs before chamber formation and acquisition of bona fide atrial or ventricular identity. However, the mechanisms underlying these early specification events remain poorly understood. Here, we performed sin ...

Mammary epithelial morphogenesis in 3D combinatorial microenvironments

Chattez avec Graph Search

Boosting CAR T-cell therapy through G-protein signal rewiring

tRNA-derived fragments in T lymphocyte-beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure