Cell-responsive hydrogel for encapsulation of vascular cells

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Organoids, miniature tissues generated from self-organizing stem cells within three-dimensional (3D) extracellular matrices (ECM), have opened up exciting possibilities for in vitro studies of complex physiological processes. A key factor in the success of ...

Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis. Here, we hypothesized that sodium thiosulfate (STS), a clinically relevant source ...

Cell-to-cell variability plays a key role in tissue patterning by setting initial asymmetry that primes cell fate decisions. Fluctuations in the activity of regulatory molecules can commit individual cells to divergent differentiation pathways, and cell-to ...

Load-bearing tissues such as articular cartilage or meniscus are not infallible. They might fail due to trauma, over-solicitations, or diseases, which could subsequently alter the mobility of the patient. Repairing these damaged tissues in a minimally inva ...

Intracranial aneurysm is a cerebrovascular disease characterized by an artery dilation in the brain. An aneurysm is prone to rupture, which causes a life-threatening subarachnoid hemorrhage. The major drawbacks of the current treatments, open surgical clip ...

An alternative intracranial aneurysm embolic agent is emerging in the form of hydrogels due to their ability to be injected in liquid phase and solidify in situ. Hydrogels have the ability to fill an aneurysm sac more completely compared to solid implants ...

Polymers containing PdnL2n complexes as network junctions were obtained by reaction of poly(ethylene glycol)-linked N-donor ligands with Pd2+. The addition of a metastable state photoacid renders the networks light sensitive, and gel–sol transitions can be ...

There has been a considerable interest in developing stiff, strong, tough, and highly stretchable hydrogels in various fields of science and technology including biomedical and sensing applications. However, simultaneous optimization of stiffness, strength ...

We investigate the regularity of the free boundary for the Signorini problem in Rn+1. It is known that regular points are (n−1)-dimensional and C∞. However, even for C∞ obstacles φ, the set of non-regular (or degenerate) points could be very large—e.g. wit ...

Single-cell cloning is essential in stem cell biology, cancer research, and biotechnology. Regulatory agencies now require an indisputable proof of clonality that current technologies do not readily provide. Here, we report a one-step cloning method using ...

We earlier showed that outside-in integrin signaling through POSTN-ITGAV interaction plays an important role in regulating adult he-matopoietic stem cell (HSC) quiescence. Here, we show that Itgav deletion results in increased frequency of phenotypic HSCs ...

Nowadays, the development of cell therapy relies mainly on the advances made toward cell microencapsulation which allows to evade the need for immunosuppression during cell transplantation. Among the materials considered for cell encapsulation, hydrogels d ...

Due to their selective crosslinking chemistry and well-defined mechano-biochemical characteristics, hydrogels crosslinked by thiol-Michael addition reactions have garnered immense interest for 3D cell culture applications. These hydrogels are typically for ...

Despite the development of hydrogels with high mechanical properties, insufficient adhesion between these materials and biological surfaces significantly limits their use in the biomedical field. By controlling toughening processes, we designed a composite ...

The invention provides a method for obtaining a three-dimensional (3D) cellular model of tissue fibrosis, such as liver fibrosis, comprising culturing epithelial cells in a 3D hydrogel in conditions suitable for a three-dimensional cellular cluster formati ...

One of the novel approaches for discogenic lower back pain treatment is to permanently replace the core of the intervertebral disc, so-called Nucleus Pulposus, through minimally invasive surgery. Recently, we have proposed Poly(Ethylene Glycol) Dimethacryl ...

Sirtuin 1 (Sirt1) is a NAD(+)-dependent deacetylase capable of countering age-related neurodegeneration, but the basis of Sirt1 neuroprotection remains elusive. Spinocerebellar ataxia type 7 (SCA7) is an inherited CAG-polyglutamine repeat disorder. Transcr ...

The invention provides hydrogels and methods for three-dimensional (3D) culture of adult epithelial stem cells and uses thereof. ...

Despite the improving imaging techniques, it remains challenging to produce magnetic resonance (MR) imaging fingerprints depicting severity of acute ischemia. The aim of this study was to evaluate the potential of the overall high-field H-1 MR Spectroscopy ...

Developing hydrogels with optimal properties for specific applications is challenging as most of these properties, such as toughness, stiffness, swelling or deformability, are interrelated. The improvement of one property usually comes at the cost of anoth ...

Cell-responsive hydrogel for encapsulation of vascular cells

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Engineering hydrogel microenvironments for epithelial organoid culture

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

Single-cell lipidomics reveals a role for cell-to-cell sphingolipid heterogeneity in fibroblast activation

Hybrid hydrogels for load-bearing implants

In situ photopolymerizable hydrogels for intracranial aneurysms treatment

Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

Light-induced assembly and disassembly of polymers with PdnL2n-type network junctions

Stiff, Strong, Tough, and Highly Stretchable Hydrogels Based on Dual Stimuli-Responsive Semicrystalline Poly(urethane–urea) Copolymers

Free Boundary Regularity for Almost Every Solution to the Signorini Problem

Traceable Impedance-Based Dispensing and Cloning of Living Single Cells

The Periostin/Integrin-alpha v Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver

Development of functionalized alginate-based hydrogels to reduce fibrosis in the transplantation of microencapsulated cells

Low-Defect Thiol-Michael Addition Hydrogels as Matrigel Substitutes for Epithelial Organoid Derivation

Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces

Three dimensional models of tissue fibrosis

Tailoring swelling to control softening mechanisms during cyclic loading of PEG/cellulose hydrogel composites

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7

Three dimensional hydrogels for culturing organoids

Metabolic fingerprints discriminating severity of acute ischemia using in vivo high-field H-1 magnetic resonance spectroscopy

Hybrid granular hydrogels: combining composites and microgels for extended ranges of material properties