The studies of ParA and ParB dynamics reveal asymmetry of chromosome segregation in mycobacteria

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Meiotic processes are potentially dangerous to genome stability and could be disastrous if activated in proliferative cells. Here we show that two key meiosis-defining proteins, the topoisomerase Spo11 (which forms double-strand breaks) and the meiotic coh ...

The inner nuclear membrane is functionalized by diverse transmembrane proteins that associate with nuclear lamins and/or chromatin. When cells enter mitosis, membrane-chromatin contacts must be broken to allow for proper chromosome segregation; yet how thi ...

Three-component ParABS systems are widely distributed factors for plasmid partitioning and chromosome segregation in bacteria. ParB acts as adaptor protein between the 16-base pair centromeric parS DNA sequences and the DNA segregation proteins ParA and Sm ...

Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more than 2,000 human lncRNAs, we iden ...

Annonaceae family has broad uses in herbal medicine for treatment of several diseases, whether through seeds' or leaves' extracts. The present study investigates the antiproliferative and antitumor activity of Annona cherimola aqueous leaf (AAL) extract/in ...

Mycobacterium tuberculosis, the etiological agent for the tuberculosis disease, is a bacterial pathogen thought to infect about a quarter of the global human population. It is the first cause of death among infectious diseases, and is most prevalent in low ...

The studies of ParA and ParB dynamics reveal asymmetry of chromosome segregation in mycobacteria

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Coordination between cell growth, division and chromosome replication cycles in mycobacteria

Challenging endings: How telomeres prevent fragility

The makings of TERRA R-loops at chromosome ends

Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci

Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8

Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1

Relief of ParB autoinhibition by parS DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly

A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division

The pro-apoptotic properties of a phytonutrient rich infusion of A. cherimola leaf extract on AML cells

Time-lapse high-resolution microscopy to study the morphogenesis of microorganisms