Retinal vessel oxygen saturation and its correlation with structural changes in retinitis pigmentosa

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Glaucoma is one of the leading causes of irreversible blindness worldwide. Glaucoma is defined clinically as the presence of optic nerve head (ONH) degeneration and progressive loss of retinal ganglion cells (RGCs). Intra-ocular pressure (IOP) has been con ...

Background aims: Age-related macular degeneration (AMD) is the most common cause of blindness in elderly patients within developed countries, affecting more than 190 million worldwide. In AMD, the retinal pigment epithelial (RPE) cell layer progressively d ...

Understanding the factors that influence the human perception of glare is necessary to properly address glare risks in buildings and achieve comfortable visual environments, especially in the workplace. Yet large inter-individual variabilities in glare per ...

Biomimetic retinas with a wide field of view and high resolution are in demand for neuroprosthetics and robot vision. Conventional neural prostheses are manufactured outside the application area and implanted as a complete device using invasive surgery. He ...

Designing architectural façades that allow sufficient daylight to create visually comfortable and pleasant environments is a challenging aspect of building design. It requires accounting for visual comfort and discomfort glare risks and understanding the f ...

The seismic assessment of existing steel structures necessitates the development of practice- oriented engineering models for use in nonlinear static and dynamic analysis procedures. These models should encompass the full range of the anticipated nonlinear ...

Objective: To image healthy retinal pigment epithelial (RPE) cells in vivo using Transscleral OPtical Imaging (TOPI) and to analyze statistics of RPE cell features as a function of age, axial length (AL), and eccentricity. Design: Single-center, explorator ...

Zebrafish show an extraordinary potential for regeneration in several organs from fins to central nervous system. Most impressively, the outcome of an injury results in a near perfect regeneration and a full functional recovery. Indeed, among the various i ...

Retinal prostheses hold potential for artificial vision in blind people. Here, authors show that POLYRETINA, a large and high-density photovoltaic epiretinal device, restores light-evoked cortical responses in blind Gottingen minipigs at safe irradiance le ...

Background Our goal was to evaluate the performance of a new wearable arm located pulse oximeter. Methods Twelve volunteers were monitored with three pulse oximeters and underwent desaturation to 70% SaO(2). We compared the accuracy of SpO(2) reading from ...

Tim-domain near-infrared optical tomography (TD NIROT) techniques based on diffuse light were gaining performance over the last years. They are capable of imaging tissue at several centimeters depth and reveal clinically relevant information, such as tissu ...

Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, a detailed mapping of transient cellular states during in v ...

Sight restoration through retinal prostheses was still a mere dream a century ago. Current challenges are even greater: providing a quantitatively and qualitatively useful artificial vision to late blind patients. Existing approaches all face engineering a ...

Objective. Retinal stimulation in blind patients evokes the sensation of discrete points of light called phosphenes, which allows them to perform visually guided tasks, such as orientation, navigation, object recognition, object manipulation and reading. H ...

Purpose: To report multimodal imaging findings including optical coherence tomography angiography (OCT-A) of a patient presenting with a quiescent choroidal neovascularization (CNV) in one eye and an active CNV in the fellow eye, complicating retinitis pig ...

Retinal prostheses hold the promise of restoring vision in totally blind people. However, a decade of clinical trials highlighted quantitative limitations hampering the possibility of reaching this goal. A key challenge in retinal stimulation is to indepen ...

Objective To develop a fully automated method of retinal pigmented epithelium (RPE) cells detection, segmentation and analysis based on in vivo cellular resolution images obtained with the transscleral optical phase imaging method (TOPI). Methods Fourteen ...

There is growing interest in organic semiconductor devices for light-mediated neuromodulation, such as for retinal stimulation. Here, the key working principles of these devices are discussed, as well as promising applications and outstanding challenges fo ...

We designed and tested a device to stimulate specifically one photoreceptor type, or a combination of some of them, of the human eye by using up to six primaries. The device produces a homogeneous light field over 40 degrees which is projected onto the ret ...

Structural engineers play an increasing role in ensuring the transition towards a more sustainable construction sector: a) they are responsible for the design of the most resource- and energy-intensive part of buildings and infrastructure, and b) they regu ...

Retinal vessel oxygen saturation and its correlation with structural changes in retinitis pigmentosa

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Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

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In Vivo Retinal Pigment Epithelium Imaging using Transscleral Optical Imaging in Healthy Eyes

Incomplete Recovery of Zebrafish Retina Following Cryoinjury

POLYRETINA restores light responses in vivo in blind Gottingen minipigs

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Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation

Photovoltaic stimulation of retinal microcircuit for vision restoration

Naturalistic spatiotemporal modulation of epiretinal stimulation increases the response persistence of retinal ganglion cell

OCT-angiography assessing quiescent and active choroidal neovascularization in retinitis pigmentosa associated with PRPH2 pathogenic variant

Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas

Fully automated detection, segmentation, and analysis of in vivo RPE single cells

Organic semiconductors for light-mediated neuromodulation

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