Publications related to Compact low-power recording architecture for multichannel acquisition of biological signals and method for compressing said biological signal data

Electromagnetic Radiation of Implantable Antennas

In the development of implantable bioelectronics, the establishment of efficient wireless RF links between implants and external nodes is crucial, providing substantial contributions to the advancement of medical diagnosis, therapies, and basic science. Im ...

EPFL2024

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

Mathieu Girardin

Chimeric antigen receptors (CARs) are synthetic, transmembrane proteins that trigger immune cell signaling following their engagement. They have been first utilized in T cells and later in natural killer (NK) cells to redirect their cytotoxicity toward a s ...

EPFL2023

Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo

Samuel William Vernon

Central nervous system organogenesis is a complex process that obeys precise architectural rules. The impact that nervous system architecture may have on its functionality remains, however, relatively unexplored. To clarify this problem, we analyze the dev ...

Nature Portfolio2023

Time vs. Truth: Age-Distortion Tradeoffs and Strategies for Distributed Inference

Yunus Inan

In 1948, Claude Shannon laid the foundations of information theory, which grew out of a study to find the ultimate limits of source compression, and of reliable communication. Since then, information theory has proved itself not only as a quest to find the ...

EPFL2023

Characterization of Non-Stationary Signals in Electric Grids: a Functional Dictionary Approach

Mario Paolone, Asja Derviskadic, Guglielmo Frigo, Alexandra Cameron Karpilow

With the expanding role of converter-interfaced distributed energy resources, modern power grids are evolving towards low-inertia networks that are increasingly vulnerable to extreme dynamics. Consequently, advanced signal processing techniques are needed ...

IEEE Institute of Electrical and Electronics Engineers2021

Modeling metabolic and signaling pathways in cancer cells

Maria Masid Barcon

Cancer is a leading cause of death in the world, and the mechanisms that underlie this disease are still not completely understood. As cancer develops and progresses, cells undergo a diversity of mutations that sustain their rapid proliferation and the eva ...

EPFL2020

Sparse and Parametric Modeling with Applications to Acoustics and Audio

Helena Peic Tukuljac

Recent advances in signal processing, machine learning and deep learning with sparse intrinsic structure of data have paved the path for solving inverse problems in acoustics and audio. The main task of this thesis was to bridge the gap between the powerfu ...

EPFL2020

Regulation of adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals

Ursula Röthlisberger, Paolo Carloni, Siri Camee van Keulen, Daniele Narzi

Author summary Adenylyl cyclases (ACs) are enzymes that can translate extracellular signals into the intracellular molecule cAMP, which is thus a 2nd messenger of extracellular events. The brain expresses nine membrane-bound AC variants, and AC5 is the dom ...

2019

A Sub-μW/Channel, 16-Channel Seizure Detection and Signal Acquisition SoC Based on Multichannel Compressive Sensing

Alexandre Schmid, Reza Ranjandish

An accurate 16-channel seizure detection system-on-chip is presented, which is based on extracting features from the compressed recorded data using multichannel compressive sensing (MCS). MCS is used to reduce the transmission data rate of sparse biologica ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2018

Adaptive Learning-Based Compressive Sampling for Low-power Wireless Implants

Catherine Dehollain, Yusuf Leblebici, Volkan Cevher, Mahsa Shoaran, Gürkan Yilmaz, Franco Maloberti, Cosimo Aprile, Kerim Türe, Luca Baldassarre

Implantable systems are nowadays being used to interface the human brain with external devices, in order to understand and potentially treat neurological disorders. The most predominant design constraints are the system’s area and power. In this paper, we ...

2018

Lossy compression of quality scores in differential gene expression: A first assessment and impact analysis

Ana Angelica Hernandez Lopez

High-throughput sequencing of RNA molecules has enabled the quantitative analysis of gene expression at the expense of storage space and processing power. To alleviate these prob- lems, lossy compression methods of the quality scores associated to RNA sequ ...

2018

Evaluation of ICtCp color space and an Adaptive Reshaper for HDR and WCG

Touradj Ebrahimi, Martin Rerabek, Anne-Flore Nicole Marie Perrin

New emerging technologies in the field of multimedia, such as high dynamic range and wide color gamut, challenge the performance of existing image and video data processing algorithms, especially in terms of visual data compression and its faithful represe ...

2018

An area and power efficient on-the-fly LBCS transformation for implantable neuronal signal acquisition systems

Yusuf Leblebici, Volkan Cevher, Cosimo Aprile, Luca Baldassarre

A power and area effcient hardware encoding system tailored for wireless implantable applications is presented. Constant medical monitoring allowed by implantable devices is the most relevant alternative to current bulky monitoring systems, which, in case ...

2018

An area and power efficient on-the-fly LBCS transformation for implantable neuronal signal acquisition systems

Yusuf Leblebici, Volkan Cevher, Cosimo Aprile, Luca Baldassarre

A power and area efficient hardware encoding system tailored for wireless implantable applications is presented. Constant medical monitoring allowed by implantable devices is the most relevant alternative to current bulky monitoring systems, which, in case ...

ASSOC COMPUTING MACHINERY2018

A Synchronization-Based Hybrid-Memory Multi-Core Architecture for Energy-Efficient Biomedical Signal Processing

David Atienza Alonso, Luca Benini, Ruben Braojos Lopez, Giovanni Ansaloni

In the last decade, improvements on technology scaling have enabled the design of a novel generation of wearable bio-sensing monitors. These smart Wireless Body Sensor Nodes (WBSNs) are able to acquire and process biological signals, such as electrocardiog ...

Institute of Electrical and Electronics Engineers2017

DCT Learning-Based Hardware Design for Neural Signal Acquisition Systems

Yusuf Leblebici, Volkan Cevher, Cosimo Aprile, Luca Baldassarre

This work presents an area and power efficient encoding system for wireless implantable devices capable of monitoring the electrical activity of the brain. Such devices are becoming an important tool for understanding, real-time monitoring, and potentially ...

2017

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

Jean Philippe Boquete, Bruno Lemaitre, Sveta Chakrabarti, Esther Jeanne Collas, Jan Paul Dudzic, Xiaoxue Li

The JAK/STAT pathway is a key signaling pathway in the regulation of development and immunity in metazoans. In contrast to the multiple combinatorial JAK/STAT pathways in mammals, only one canonical JAK/STAT pathway exists in Drosophila. It is activated by ...

Public Library of Science2016

Ultra-low-power ECG front-end design based on compressed sensing

Pierre Vandergheynst, Hossein Mamaghanian

Ultra-low-power design has been a challenging area for design of the sensor front-ends especially in the area of Wireless Body Sensor Nodes (WBSN), where a limited amount of power budget and hardware resources are available. Since introduction of Compresse ...

ACM/IEEE Press2015

Low-Power Circuit and System Design for Epileptic Seizure Detection at High Spatiotemporal Resolution

Mahsa Shoaran

Smart and miniaturized implantable microsystems with diagnostic and therapeutic capabilities are becoming increasingly important for patients suffering from neurological disorders such as epilepsy. Recent developments in microfabrication technology have pr ...

EPFL2015

Single-Molecule Imaging Deciphers the Relation between Mobility and Signaling of a Prototypical G Protein-Coupled Receptor in Living Cells

Horst Vogel, Joachim Piguet, Luc Veya

Lateral diffusion enables efficient interactions between membrane proteins leading to signal transmission across the plasma membrane. An open question is how the spatio-temporal distribution of cell surface receptors influences the transmembrane signaling ...

American Society for Biochemistry and Molecular Biology2015