Mapping the function of neuronal ion channels in model and experiment

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Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation ...

Ordered two-dimensional (2D) materials hosting Å-scale pores are highly promising for enabling challenging separation, thanks to well-defined pore geometry resulting in tight confinement of ions when hosted inside the pore. In addition, the 2D nature of th ...

With the capabilities such as single-photon detection, time stamping and high-speed acquisition, time-resolved imaging based on single-photon avalanche diode (SPAD) detectors has found significant applications across diverse domains, including but not limi ...

Riparian vegetation, which is commonly found in natural rivers and open channels, has a strong influence on flow structures. This paper describes a laboratory experiment on velocity distributions, secondary currents, and coherent structures in narrow open- ...

Background: Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated endeavors ...

Interactive mobile applications like web browsing and gaming are known to benefit significantly from low latency networking, as applications communicate with cloud servers and other users' devices. Emerging mobile channel standards have not met these needs ...

Transport through quantum coherent conductors, such as atomic junctions, is described by conduction channels. Information about the number of channels and their transmissions can be extracted from various sources, such as multiple Andreev reflections, dyna ...

In the discussed paper [N. Starkman, H. Winch, J. S. Sidhu, and G. Starkman, Straight lightning as a signature of macroscopic dark matter, Phys. Rev. D 103, 063024 (2021)], the authors have made several assumptions and statements concerning the initiation ...

Detailed single neuron modeling is widely used to study neuronal functions. While cellular and functional diversity across the mammalian cortex is vast, most of the available computational tools are dedicated to the reproduction of a small set of specific ...

Due to conservation of neuronal functioning across phyla, molecular targets of insecticides are similar in insects and vertebrates. Insecticides thus pose a risk to aquatic vertebrates, such as fish, and potentially cause neurotoxic effects. Although these ...

An automatic seizure detection method from high-resolution intracranial-EEG (iEEG) signals is presented to minimize the computational complexity and realize real-time accurate seizure detection for biomedical implants. Complex signal processing on a large ...

Fast synaptic transmission relies upon the activation of ionotropic receptors by neurotransmitter release to evoke postsynaptic potentials. Glutamate and GABA play dominant roles in driving highly dynamic activity in synaptically connected neuronal circuit ...

A recent study pointed out that macroscopic dark matter (macros) traversing through the Earth’s atmosphere can give rise to hot and ionized channels similar to those associated with lightning leaders. The authors of the study investigated the possibility t ...

Automatic methods for detecting presentation attacks are essential to ensure the reliable use of facial recognition technology. Most of the methods available in the litera- ture for presentation attack detection (PAD) fails in gen- eralizing to unseen atta ...

Voice communication is the main channel to exchange information between pilots and Air-Traffic Controllers (ATCos). Recently, several projects have explored the employment of speech recognition technology to automatically extract spoken key information suc ...

Lipid membranes are complex and dynamic systems which are known to mediate signaling processes between cells and their environment. To do this multiple ion channels and pumps are involved in controlling the in- and out-flux of various ions (K+, Na+, Mg2+, ...

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

Sequentially stacked impingement channels allow for a more effective use of the cooling fluid and can limit the heat transfer reduction due to the crossflow when the number of jets increases. In this paper, sequential impingement channels are experimentall ...

The present paper discusses the climatic effects of humidity and temperature on cochlear implant functioning and the quality of the electrical sound signal. MATLAB Simulink simulations were prepared, offering insights into signal behavior under such climat ...

Anatomically and biophysically detailed data-driven neuronal models have become widely used tools for understanding and predicting the behavior and function of neurons. Due to the increasing availability of experimental data from anatomical and electrophys ...

Mapping the function of neuronal ion channels in model and experiment

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Structural heterogeneity of the ion and lipid channel TMEM16F

Crystal, defect, and morphology engineering of porous two-dimensional materials for ionic separation

Time-resolved imaging with SPAD detectors

Experimental study on velocity distributions, secondary currents, and coherent structures in open channel flow with submerged riparian vegetation

lifex-ep: a robust and efficient software for cardiac electrophysiology simulations

DChannel: Accelerating Mobile ApplicationsWith Parallel High-bandwidth and Low-latency Channels

Extracting transport channel transmissions in scanning tunneling microscopy using superconducting excess current

Comment on “Straight lightning as a signature of macroscopic dark matter”

A universal workflow for creation, validation and generalization of detailed neuronal models

Mechanistic Understanding of Neurobehavioral Effects of Insecticides on the Larvae of Zebrafish (Danio rerio)

Computation Complexity Reduction Technique for Accurate Seizure Detection Implants

Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing

Could Macroscopic Dark Matter (Macros) Give Rise to Mini-Lightning Flashes out of a Blue Sky without Clouds?

Cross Modal Focal Loss for RGBD Face Anti-Spoofing

Automatic Call Sign Detection: Matching Air Surveillance Data with Air Traffic Spoken Communications

Passive and active ion permeation through lipid bilayers investigated by second harmonic water imaging

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Experimental investigation of sequential narrow impingement channels for turbine cooling

Electrical Signal Modeling in Cochlear Implants. Study of Temperature and Humidity Effects

HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data