Publications associées à Mapping the function of neuronal ion channels in model and experiment

Structural heterogeneity of the ion and lipid channel TMEM16F

Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation ...

Nature Portfolio2024

Crystal, defect, and morphology engineering of porous two-dimensional materials for ionic separation

Heng-Yu Chi

Ordered two-dimensional (2D) materials hosting Å-scale pores are highly promising for enabling challenging separation, thanks to well-defined pore geometry resulting in tight confinement of ions when hosted inside the pore. In addition, the 2D nature of th ...

EPFL2024

Time-resolved imaging with SPAD detectors

Jiuxuan Zhao

With the capabilities such as single-photon detection, time stamping and high-speed acquisition, time-resolved imaging based on single-photon avalanche diode (SPAD) detectors has found significant applications across diverse domains, including but not limi ...

EPFL2023

Experimental study on velocity distributions, secondary currents, and coherent structures in open channel flow with submerged riparian vegetation

Haoran Shi

Riparian vegetation, which is commonly found in natural rivers and open channels, has a strong influence on flow structures. This paper describes a laboratory experiment on velocity distributions, secondary currents, and coherent structures in narrow open- ...

ELSEVIER SCI LTD2023

lifex-ep: a robust and efficient software for cardiac electrophysiology simulations

Alfio Quarteroni, Francesco Regazzoni, Marco Fedele, Stefano Pagani

Background: Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated endeavors ...

BMC2023

DChannel: Accelerating Mobile ApplicationsWith Parallel High-bandwidth and Low-latency Channels

Haitham Al Hassanieh

Interactive mobile applications like web browsing and gaming are known to benefit significantly from low latency networking, as applications communicate with cloud servers and other users' devices. Emerging mobile channel standards have not met these needs ...

USENIX ASSOC2023

Extracting transport channel transmissions in scanning tunneling microscopy using superconducting excess current

Klaus Kern, Markus Etzkorn, Jacob Senkpiel

Transport through quantum coherent conductors, such as atomic junctions, is described by conduction channels. Information about the number of channels and their transmissions can be extracted from various sources, such as multiple Andreev reflections, dyna ...

AMER PHYSICAL SOC2022

Comment on “Straight lightning as a signature of macroscopic dark matter”

Farhad Rachidi-Haeri, Marcos Rubinstein

In the discussed paper [N. Starkman, H. Winch, J. S. Sidhu, and G. Starkman, Straight lightning as a signature of macroscopic dark matter, Phys. Rev. D 103, 063024 (2021)], the authors have made several assumptions and statements concerning the initiation ...

2022

A universal workflow for creation, validation and generalization of detailed neuronal models

Henry Markram, Srikanth Ramaswamy, Alexis Arnaudon, Werner Alfons Hilda Van Geit, Christian Andreas Rössert, Mustafa Anil Tuncel, Tanguy Pierre Louis Damart, Maria Reva, Darshan Mandge

Detailed single neuron modeling is widely used to study neuronal functions. While cellular and functional diversity across the mammalian cortex is vast, most of the available computational tools are dedicated to the reproduction of a small set of specific ...

Cambridge2023

Mechanistic Understanding of Neurobehavioral Effects of Insecticides on the Larvae of Zebrafish (Danio rerio)

Sarah-Katharina Könemann

Due to conservation of neuronal functioning across phyla, molecular targets of insecticides are similar in insects and vertebrates. Insecticides thus pose a risk to aquatic vertebrates, such as fish, and potentially cause neurotoxic effects. Although these ...

EPFL2022

Computation Complexity Reduction Technique for Accurate Seizure Detection Implants

Alexandre Schmid, Keyvan Farhang Razi

An automatic seizure detection method from high-resolution intracranial-EEG (iEEG) signals is presented to minimize the computational complexity and realize real-time accurate seizure detection for biomedical implants. Complex signal processing on a large ...

IEEE2022

Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing

Carl Petersen, Sylvain Crochet, Célia Roxane Gasselin, Benoît Hohl

Fast synaptic transmission relies upon the activation of ionotropic receptors by neurotransmitter release to evoke postsynaptic potentials. Glutamate and GABA play dominant roles in driving highly dynamic activity in synaptically connected neuronal circuit ...

CELL PRESS2021

Could Macroscopic Dark Matter (Macros) Give Rise to Mini-Lightning Flashes out of a Blue Sky without Clouds?

Farhad Rachidi-Haeri, Marcos Rubinstein

A recent study pointed out that macroscopic dark matter (macros) traversing through the Earth’s atmosphere can give rise to hot and ionized channels similar to those associated with lightning leaders. The authors of the study investigated the possibility t ...

2021

Cross Modal Focal Loss for RGBD Face Anti-Spoofing

Sébastien Marcel

Automatic methods for detecting presentation attacks are essential to ensure the reliable use of facial recognition technology. Most of the methods available in the litera- ture for presentation attack detection (PAD) fails in gen- eralizing to unseen atta ...

IEEE2021

Automatic Call Sign Detection: Matching Air Surveillance Data with Air Traffic Spoken Communications

Petr Motlicek, Amrutha Prasad

Voice communication is the main channel to exchange information between pilots and Air-Traffic Controllers (ATCos). Recently, several projects have explored the employment of speech recognition technology to automatically extract spoken key information suc ...

MDPI2021

Passive and active ion permeation through lipid bilayers investigated by second harmonic water imaging

Maksim Eremchev

Lipid membranes are complex and dynamic systems which are known to mediate signaling processes between cells and their environment. To do this multiple ion channels and pumps are involved in controlling the in- and out-flux of various ions (K+, Na+, Mg2+, ...

EPFL2021

Experimental investigation of sequential narrow impingement channels for turbine cooling

Peter Ott, Michele Gaffuri

Sequentially stacked impingement channels allow for a more effective use of the cooling fluid and can limit the heat transfer reduction due to the crossflow when the number of jets increases. In this paper, sequential impingement channels are experimentall ...

2021

Electrical Signal Modeling in Cochlear Implants. Study of Temperature and Humidity Effects

Maria-Alexandra Paun

The present paper discusses the climatic effects of humidity and temperature on cochlear implant functioning and the quality of the electrical sound signal. MATLAB Simulink simulations were prepared, offering insights into signal behavior under such climat ...

MDPI2021

HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data

Eilif Benjamin Muller, Werner Alfons Hilda Van Geit, Armando Romani, Szabolcs Kali, Sàra Sàray, Carmen Alina Lupascu, Rosanna Migliore, Luca Leonardo Bologna, Shailesh Appukuttan

Anatomically and biophysically detailed data-driven neuronal models have become widely used tools for understanding and predicting the behavior and function of neurons. Due to the increasing availability of experimental data from anatomical and electrophys ...

2021

P-GaN Tri-Gate MOS Structure for Normally-Off GaN Power Transistors

Elison de Nazareth Matioli, Jun Ma, Minghua Zhu, Pirouz Sohi, Catherine Erine, Mohammad Samizadeh Nikooytabalvandani, Luca Nela

In this letter, we present a new concept for normally-off AlGaN/GaN-on-Si MOS-HEMTs based on the combination of p-GaN, tri-gate and MOS structures to achieve high threshold voltage (V-TH) and low on-resistance (R-ON). The p-GaN is used to engineer the band ...

Institute of Electrical and Electronics Engineers2021