Publication

Odor-structure relationships using fluorine as a probe

Manfred Schlosser
2000
Journal Articles

Abstract

Eight ethers, nine esters and one ketone were submitted to a systematic structural variation by replacing a hydrogen atom in the vicinity of the oxo function by fluorine and Me. As long as steric factors dominate, a fluorine substituent alters the olfactory properties of the parent compd. much less than a Me substituent does. However, if it occupies a position adjacent to a carbonyl group, the halogen may more profoundly affect the odor perception, presumably as a consequence of conformational changes. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/b26e3c24-d515-4e70-bb3a-346fbee5bf20

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Manfred Schlosser
2000
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/b26e3c24-d515-4e70-bb3a-346fbee5bf20

About this result

Related concepts (32)

Substituent

In organic chemistry, a substituent is one or a group of atoms that replaces (one or more) atoms, thereby becoming a moiety in the resultant (new) molecule. (in organic chemistry and biochemistry, the terms substituent and functional group, as well as side chain and pendant group, are used almost interchangeably to describe those branches from the parent structure, though certain distinctions are made in polymer chemistry. In polymers, side chains extend from the backbone structure.

Sense of smell

The sense of smell, or olfaction, is the special sense through which smells (or odors) are perceived. The sense of smell has many functions, including detecting desirable foods, hazards, and pheromones, and plays a role in taste. In humans, it occurs when an odor binds to a receptor within the nasal cavity, transmitting a signal through the olfactory system. Glomeruli aggregate signals from these receptors and transmit them to the olfactory bulb, where the sensory input will start to interact with parts of the brain responsible for smell identification, memory, and emotion.

Ester

In chemistry, an ester is a compound derived from an acid (organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group () of that acid is replaced by an organyl group (). Analogues derived from oxygen replaced by other chalcogens belong to the ester category as well. According to some authors, organyl derivatives of acidic hydrogen of other acids are esters as well (e.g. amides), but not according to the IUPAC.

Related publications (8)

Odor-structure relationships using fluorine as a probe

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