Direct Observation of Transitions between Surface-Dominated and Bulk Diffusion Regimes in Nanochannels

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The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep learning-driven structure prediction, increased speed and resolution of structure elucidation, machine learni ...

Post-translational modifications (PTMs) play a pivotal role in regulating protein structure, interaction, and function. Aberrant PTM patterns are associated with diseases. Moreover, individual PTMs have a complex interaction with each other, known as PTM c ...

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Membrane fusion is essential for the basal functionality of eukaryotic cells. In physiological conditions, fusion events are regulated by a wide range of specialized proteins, operating with finely tuned local lipid composition and ionic environment. Fusog ...

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A method for determining the presence of a molecule coupled to the cytoplasmic side of a cellular membrane is disclosed. The method is implemented in a microfluidic setting and is particularly suitable for determining the presence and/or the activity of a ...

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Hydrated lipid bilayer membranes and their asymmetry play a fundamental role in living cells by maintaining and regulating concentration gradients between cells, their environment, and their compartments. They achieve this not only through various channels ...

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Direct Observation of Transitions between Surface-Dominated and Bulk Diffusion Regimes in Nanochannels

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Computational drug development for membrane protein targets

Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions

Membrane specificity of the human cholesterol transfer protein STARD4

S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Effects of thermal, mechanical, and electrostatic perturbations on lipid membrane hydration investigated by second harmonic imaging

Simultaneous membrane and RNA binding by Tick-Borne Encephalitis Virus capsid protein

Interplay of the mechanical and structural properties of DNA nanostructures determines their electrostatic interactions with lipid membranes

Cholesterol-Containing Liposomes Decorated With Au Nanoparticles as Minimal Tunable Fusion Machinery

Liposomes and Lipid Droplets Display a Reversal of Charge-Induced Hydration Asymmetry

Information Theory in Transmembrane Transport

Refining S-acylation: Structure, regulation, dynamics, and therapeutic implications

Development of methods for the synthesis of large combinatorial libraries of macrocyclic compounds

Structural diversity of photoswitchable sphingolipids for optodynamic control of lipid microdomains

Second harmonic scattering of water in a biological context

Method and system for determining intracellular mediators' activity

2D MoS2 Nanopores: Wafer-scale Fabrication and Monolayer Stability for Long-term Single-Molecule Sensing

Water as a contrast agent for imaging interfacial structure and ion transport in giant vesicles

Neurite Exchange Imaging ((NEXI): A minimal model of diffusion in gray matter with inter-compartment water exchange

De novo developed small cyclic peptides that are orally available