The rise and fall of Hox gene clusters

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During gastrulation, Hox genes are activated in a timesequence that follows the order of the genes along their clusters. This property, which is observed in all animals that develop following a progressive rostral-to-caudal morphogenesis, is associated wit ...

The Septation Initiation Network (SIN) is a conserved signal transduction network, which is important for cytokinesis in S. pombe. The SIN component Etd1p is required for association of some SIN proteins with the spindle pole body (SPB) during anaphase and ...

Terrestrial particle accelerators collide charged particles, then watch the trajectory of outgoing debris - but they cannot manipulate dark matter. Fortunately, dark matter is the main component of galaxy clusters, which are continuously pulled together by ...

We use 0.1 '' observations from the Atacama Large Millimeter Array (ALMA), Hubble Space Telescope (HST), and JWST to study young massive clusters (YMCs) in their embedded "infant" phase across the central starburst ring in NGC 3351. Our new ALMA data revea ...

Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed tr ...

The radial metallicity distribution of the Milky Way's disc is an important observational constraint for models of the formation and evolution of our Galaxy. It informs our understanding of the chemical enrichment of the Galactic disc and the dynamical pro ...

We investigate the role of dense environments in suppressing star formation by studying log(10)(M- * / M-?) > 9 . 7 star-forming galaxies in nine clusters from the Local Cluster Survey (0.0137 < z < 0.0433) and a large comparison field sample drawn from th ...

Surface stress drives long-range elastocapillary interactions at the surface of compliant solids, where it has been observed to mediate interparticle interactions and to alter the transport of liquid drops. We show that such an elastocapillary interaction ...

Binding to binding site clusters has yet to be characterized in depth, and the functional relevance of low-affinity clusters remains uncertain. We characterized transcription factor binding to low-affinity clusters in vitro and found that transcription fac ...

Context. Some of the youngest stars (age less than or similar to 10 Myr) are clustered, while many others are observed scattered throughout star forming regions or in complete isolation. It has been intensively debated whether such scattered or isolated st ...

It was recently shown that almost all solutions in the symmetric binary perceptron are isolated, even at low constraint densities, suggesting that finding typical solutions is hard. In contrast, some algorithms have been shown empirically to succeed in fin ...

Measurements of aerosol particles and clusters smaller than 3 nm in diameter are performed by many groups in order to detect recently formed or emitted nanoparticles and for studying the formation and early growth processes of aerosol particles. The Airmod ...

A simple model to study subspace clustering is the high-dimensional k -Gaussian mixture model where the cluster means are sparse vectors. Here we provide an exact asymptotic characterization of the statistically optimal reconstruction error in this model i ...

Stellar ejecta gradually enrich the gas out of which subsequent stars form, making the least chemically enriched stellar systems direct fossils of structures formed in the early Universe(1). Although a few hundred stars with metal content below 1,000th of ...

The proposition that life can spread from one planetary system to another (interstellar panspermia) has a long history, but this hypothesis is difficult to test through observations. We develop a mathematical model that takes parameters such as the microbi ...

The COnstrain Dark Energy with X-ray clusters (CODEX) sample contains the largest flux limited sample of X-ray clusters at 0.35 < z < 0.65. It was selected from ROSAT data in the 10 000 square degrees of overlap with BOSS, mapping a total number of 2770 hi ...

To understand the geographical and temporal spread of SARS-CoV-2 during the first documented wave of infection in the state of Vaud, Switzerland, we analyzed clusters of positive cases using the precise residential location of 33,651 individuals tested (RT ...

In this study, Amandio et al. sought to understand the functions of the highly conserved CTCF sites distributed over the Hox gene clusters. The authors produced an allelic series of cumulative in cis mutations in these sites, up to the abrogation of CTCF b ...

A number of the massive clusters in the halo, bulge, and disc of the Galaxy are not genuine globular clusters (GCs) but instead are different beasts altogether. They are the remnant nuclear star clusters (NSCs) of ancient galaxies since accreted by the Mil ...

The rise and fall of Hox gene clusters

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Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

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Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster

The accreted nuclear clusters of the Milky Way